Early lineage switch from T-acute lymphoblastic leukaemia to common B-all.
Leukaemic stem cells have heterogenous differentiation potential. The immunophenotypes of blast cells are usually consistent throughout the disease course even at relapse. Rarely, blast cells may undergo a ‘lineage switch’ during the course of disease especially during relapse. We would like to high...
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| Format: | Article |
| Language: | English |
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Penerbit UKM
2011
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| Online Access: | http://journalarticle.ukm.my/5326/ http://journalarticle.ukm.my/5326/1/11-MS126_%28131-138%29.pdf |
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| author | Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH |
| author_facet | Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH |
| author_sort | Hafiza, A |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Leukaemic stem cells have heterogenous differentiation potential. The immunophenotypes of blast cells are usually consistent throughout the disease course even at relapse. Rarely, blast cells may undergo a ‘lineage switch’ during the course of disease especially during relapse. We would like to highlight such a case in a 10-year old boy who presented with a two weeks history of lethargy, poor appetite, low grade fever, respiratory distress, cardiac failure, generalized oedema and hepatosplenomegaly. Full blood count showed a leucocyte count of 41.5x109/L and platelet count of 37x109/L. The peripheral blood film showed presence of numerous blast cells. Bone marrow aspiration revealed a hypercellular marrow, which consisted of mainly blast cells with high nuclear to cytoplasmic ratio and inconspicuous nucleoli. Immunophenotyping and cytochemistry results were consistent with the diagnosis of T-cell acute lymphoblastic leukaemia. The patient achieved remission after treatment with UK ALL 97 protocol, regime B chemotherapy. However, he relapsed seven months after the initial diagnosis with 26% blast cells in the bone marrow aspirate. The majority was L1 blast cells admixed with some L2 blast cells. Immunophenotyping was consistent with common precursor B acute lymphoblastic leukaemia. The treatment was changed to a more lineage specific chemotherapy. Nonetheless, the patient never achieved remission and was planned for palliative management. This case illustrated a unique and rare case of rapid lineage switch from T-cell acute lymphoblastic leukaemia to common precursor B-cell acute lymphoblastic leukaemia. |
| first_indexed | 2025-11-14T23:36:02Z |
| format | Article |
| id | oai:generic.eprints.org:5326 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:36:02Z |
| publishDate | 2011 |
| publisher | Penerbit UKM |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:53262016-12-14T06:38:07Z http://journalarticle.ukm.my/5326/ Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH Leukaemic stem cells have heterogenous differentiation potential. The immunophenotypes of blast cells are usually consistent throughout the disease course even at relapse. Rarely, blast cells may undergo a ‘lineage switch’ during the course of disease especially during relapse. We would like to highlight such a case in a 10-year old boy who presented with a two weeks history of lethargy, poor appetite, low grade fever, respiratory distress, cardiac failure, generalized oedema and hepatosplenomegaly. Full blood count showed a leucocyte count of 41.5x109/L and platelet count of 37x109/L. The peripheral blood film showed presence of numerous blast cells. Bone marrow aspiration revealed a hypercellular marrow, which consisted of mainly blast cells with high nuclear to cytoplasmic ratio and inconspicuous nucleoli. Immunophenotyping and cytochemistry results were consistent with the diagnosis of T-cell acute lymphoblastic leukaemia. The patient achieved remission after treatment with UK ALL 97 protocol, regime B chemotherapy. However, he relapsed seven months after the initial diagnosis with 26% blast cells in the bone marrow aspirate. The majority was L1 blast cells admixed with some L2 blast cells. Immunophenotyping was consistent with common precursor B acute lymphoblastic leukaemia. The treatment was changed to a more lineage specific chemotherapy. Nonetheless, the patient never achieved remission and was planned for palliative management. This case illustrated a unique and rare case of rapid lineage switch from T-cell acute lymphoblastic leukaemia to common precursor B-cell acute lymphoblastic leukaemia. Penerbit UKM 2011-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/5326/1/11-MS126_%28131-138%29.pdf Hafiza, A and Azura, AH and Azma, RZ and Azlin, I and Zarina, AL and Hamidah, NH (2011) Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. Medicine & Health, 6 (2). pp. 131-138. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal |
| spellingShingle | Hafiza, A Azura, AH Azma, RZ Azlin, I Zarina, AL Hamidah, NH Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title | Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_full | Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_fullStr | Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_full_unstemmed | Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_short | Early lineage switch from T-acute lymphoblastic leukaemia to common B-all. |
| title_sort | early lineage switch from t-acute lymphoblastic leukaemia to common b-all. |
| url | http://journalarticle.ukm.my/5326/ http://journalarticle.ukm.my/5326/ http://journalarticle.ukm.my/5326/1/11-MS126_%28131-138%29.pdf |