Altered levels of serum haptoglobin and apo A-I in schizophrenia
Schizophrenia is a debilitating psychiatric syndrome that affects 1% of the world’s population. Abnormalities in immune functions and role of inflammatory markers have been widely described in schizophrenia. With the alarming high prevalence, this study aims to investigate the association of acute p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Kebangsaan Malaysia
2011
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| Online Access: | http://journalarticle.ukm.my/2946/ http://journalarticle.ukm.my/2946/1/18_Tze_Jen_Chow.pdf |
| _version_ | 1848810025543270400 |
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| author | Tze Jen Chow, Han Chern Loh, |
| author_facet | Tze Jen Chow, Han Chern Loh, |
| author_sort | Tze Jen Chow, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Schizophrenia is a debilitating psychiatric syndrome that affects 1% of the world’s population. Abnormalities in immune functions and role of inflammatory markers have been widely described in schizophrenia. With the alarming high prevalence, this study aims to investigate the association of acute phase proteins with schizophrenia. We investigated the serum proteome of 20 schizophrenic patients and 20 healthy controls using two-dimensional gel electrophoresis and mass spectrometry. The spots were analysed using Image Master 2D Platinum software. In total, we have detected 774 protein spots in human serum and found that three of them showed altered changes in schizophrenic patients, as compared to healthy controls. Among these acute phase proteins, haptoglobin (p = 0.003) and two isoforms of apolipoprotein A-I (p = 0.004, p = 0.003) were found to be significantly decreased in patients, as compared to controls. Our findings support the hypothesis that inflammatory response system is linked to the pathophysiology of schizophrenia. |
| first_indexed | 2025-11-14T23:23:57Z |
| format | Article |
| id | oai:generic.eprints.org:2946 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:23:57Z |
| publishDate | 2011 |
| publisher | Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:29462016-12-14T06:33:08Z http://journalarticle.ukm.my/2946/ Altered levels of serum haptoglobin and apo A-I in schizophrenia Tze Jen Chow, Han Chern Loh, Schizophrenia is a debilitating psychiatric syndrome that affects 1% of the world’s population. Abnormalities in immune functions and role of inflammatory markers have been widely described in schizophrenia. With the alarming high prevalence, this study aims to investigate the association of acute phase proteins with schizophrenia. We investigated the serum proteome of 20 schizophrenic patients and 20 healthy controls using two-dimensional gel electrophoresis and mass spectrometry. The spots were analysed using Image Master 2D Platinum software. In total, we have detected 774 protein spots in human serum and found that three of them showed altered changes in schizophrenic patients, as compared to healthy controls. Among these acute phase proteins, haptoglobin (p = 0.003) and two isoforms of apolipoprotein A-I (p = 0.004, p = 0.003) were found to be significantly decreased in patients, as compared to controls. Our findings support the hypothesis that inflammatory response system is linked to the pathophysiology of schizophrenia. Universiti Kebangsaan Malaysia 2011-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2946/1/18_Tze_Jen_Chow.pdf Tze Jen Chow, and Han Chern Loh, (2011) Altered levels of serum haptoglobin and apo A-I in schizophrenia. Sains Malaysiana, 40 (11). pp. 1319-1323. ISSN 0126-6039 http://www.ukm.my/jsm/contents.html |
| spellingShingle | Tze Jen Chow, Han Chern Loh, Altered levels of serum haptoglobin and apo A-I in schizophrenia |
| title | Altered levels of serum haptoglobin and apo A-I in schizophrenia |
| title_full | Altered levels of serum haptoglobin and apo A-I in schizophrenia |
| title_fullStr | Altered levels of serum haptoglobin and apo A-I in schizophrenia |
| title_full_unstemmed | Altered levels of serum haptoglobin and apo A-I in schizophrenia |
| title_short | Altered levels of serum haptoglobin and apo A-I in schizophrenia |
| title_sort | altered levels of serum haptoglobin and apo a-i in schizophrenia |
| url | http://journalarticle.ukm.my/2946/ http://journalarticle.ukm.my/2946/ http://journalarticle.ukm.my/2946/1/18_Tze_Jen_Chow.pdf |