The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions
The potential effectiveness of Nigella sativa oil (NSO) has been shown in patients with diabetic neuropathy. However, its safety profiles in this group of patients remain underexplored. This study aimed to evaluate the hematological and biochemical safety profiles of NSO in this population. A single...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2025
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| Online Access: | http://journalarticle.ukm.my/25988/ http://journalarticle.ukm.my/25988/1/SML%2010.pdf |
| _version_ | 1848816499947470848 |
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| author | Syuhada, Anggadiredja, Kusnandar Kurniati, Neng Fisheri Akrom, |
| author_facet | Syuhada, Anggadiredja, Kusnandar Kurniati, Neng Fisheri Akrom, |
| author_sort | Syuhada, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The potential effectiveness of Nigella sativa oil (NSO) has been shown in patients with diabetic neuropathy. However, its safety profiles in this group of patients remain underexplored. This study aimed to evaluate the hematological and biochemical safety profiles of NSO in this population. A single-center clinical trial was conducted involving 24 patients with diabetic neuropathy who received NSO at a dose of 2 mL/day for 30 days. Hematological and biochemical parameters were assessed before and after intervention. The hematological parameters included hemoglobin (HGB), white blood cell (WBC) count, red blood cell (RBC) count, hematocrit (Hct), and platelet (Plt) count. Meanwhile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine were measured representing hepatorenal parameters. Other adverse events accompanying NSO supplementation were also recorded. The results showed no significant changes in hematological parameters or hepatorenal function markers. A slight increase in mean corpuscular hemoglobin concentration (p = 0.0483) was observed, but values remained within normal physiological limits. Other adverse events reported were categorized non-serious, except one transient case of tachycardia that resolved without clinical consequences. The findings suggest that NSO is safe for patients with diabetic neuropathy. Further long-term studies with larger sample sizes are recommended to confirm these results. |
| first_indexed | 2025-11-15T01:06:51Z |
| format | Article |
| id | oai:generic.eprints.org:25988 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:06:51Z |
| publishDate | 2025 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:259882025-10-13T07:57:25Z http://journalarticle.ukm.my/25988/ The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions Syuhada, Anggadiredja, Kusnandar Kurniati, Neng Fisheri Akrom, The potential effectiveness of Nigella sativa oil (NSO) has been shown in patients with diabetic neuropathy. However, its safety profiles in this group of patients remain underexplored. This study aimed to evaluate the hematological and biochemical safety profiles of NSO in this population. A single-center clinical trial was conducted involving 24 patients with diabetic neuropathy who received NSO at a dose of 2 mL/day for 30 days. Hematological and biochemical parameters were assessed before and after intervention. The hematological parameters included hemoglobin (HGB), white blood cell (WBC) count, red blood cell (RBC) count, hematocrit (Hct), and platelet (Plt) count. Meanwhile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine were measured representing hepatorenal parameters. Other adverse events accompanying NSO supplementation were also recorded. The results showed no significant changes in hematological parameters or hepatorenal function markers. A slight increase in mean corpuscular hemoglobin concentration (p = 0.0483) was observed, but values remained within normal physiological limits. Other adverse events reported were categorized non-serious, except one transient case of tachycardia that resolved without clinical consequences. The findings suggest that NSO is safe for patients with diabetic neuropathy. Further long-term studies with larger sample sizes are recommended to confirm these results. Penerbit Universiti Kebangsaan Malaysia 2025 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/25988/1/SML%2010.pdf Syuhada, and Anggadiredja, Kusnandar and Kurniati, Neng Fisheri and Akrom, (2025) The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions. Sains Malaysiana, 54 (8). pp. 1995-2006. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol54num8_2025/contentsVol54num8_2025.html |
| spellingShingle | Syuhada, Anggadiredja, Kusnandar Kurniati, Neng Fisheri Akrom, The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions |
| title | The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions |
| title_full | The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions |
| title_fullStr | The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions |
| title_full_unstemmed | The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions |
| title_short | The safety profiles of Nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions |
| title_sort | safety profiles of nigella sativa oil as a supplement in diabetic neuropathy patients: assessment on hematology and hepatorenal functions |
| url | http://journalarticle.ukm.my/25988/ http://journalarticle.ukm.my/25988/ http://journalarticle.ukm.my/25988/1/SML%2010.pdf |