Enhanced solubility and dissolution of ketoconazole through co-amorphization with fumaric and tartaric acids via co-milling

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Enhanced solubility and dissolution of ketoconazole through co-amorphization with fumaric and tartaric acids via co-milling

This study investigates the co-amorphization of ketoconazole (KTZ) with fumaric acid (FA) and tartaric acid (TA) through co-milling, aiming to enhance the solubility, stability, and dissolution properties of this poorly water-soluble antifungal. Phase diagrams obtained via Hot Stage Microscopy (HSM)...

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Bibliographic Details
Main Authors:	Indra, Indra, Nurani, Rani, Wulandari, Winda Trisna
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2025
Online Access:	http://journalarticle.ukm.my/25818/ http://journalarticle.ukm.my/25818/1/SME%2014.pdf

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