A novel synthesis of anti-cancer drug gefitinib from 6,7-dimethoxy-3H-quinazolin-4-one

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A novel synthesis of anti-cancer drug gefitinib from 6,7-dimethoxy-3H-quinazolin-4-one

A novel synthesis of the anticancer drug gefitinib (Iressa) through novel alternative pathway has been successfully carried out. The synthesis was performed using 6,7-dimethoxy-3H-quinazolin-4-one as the starting material through four reaction stages: Chlorination, nucleophilic aromatic substitution...

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Bibliographic Details
Main Authors:	Santoso, Prio, Danova, Ade, Hermawati, Elvira, Natalia, Dessy, Alni, Anita
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2025
Online Access:	http://journalarticle.ukm.my/25630/ http://journalarticle.ukm.my/25630/1/SE%207.pdf

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