The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation
This study aims to explore the correlation between alterations in blood glucose levels and the osseointegration as well as biomechanical properties of nHA/PLLA absorbable screws, and elucidate the impact of DM on bone metabolism surrounding nHA/PLLA absorbable screws. 75 rats were randomly assigned...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2025
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| Online Access: | http://journalarticle.ukm.my/25212/ http://journalarticle.ukm.my/25212/1/SMD%2017.pdf |
| _version_ | 1848816298842128384 |
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| author | Wu, Zelin Xiao, Lei Hou, Huige Li, Ling Gao, Yanping Guan, Jian Chen, Jiwen Zeng, Lingfeng Chen, Zihang Mok, Tsz-Ngai Miao, Guiqiang Zheng, Xiaofei Yuan, Shiguo Wang, Huajun |
| author_facet | Wu, Zelin Xiao, Lei Hou, Huige Li, Ling Gao, Yanping Guan, Jian Chen, Jiwen Zeng, Lingfeng Chen, Zihang Mok, Tsz-Ngai Miao, Guiqiang Zheng, Xiaofei Yuan, Shiguo Wang, Huajun |
| author_sort | Wu, Zelin |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | This study aims to explore the correlation between alterations in blood glucose levels and the osseointegration as well as biomechanical properties of nHA/PLLA absorbable screws, and elucidate the impact of DM on bone metabolism surrounding nHA/PLLA absorbable screws. 75 rats were randomly assigned to either the Diabetes mellitus (DM) group and the control group. DM was induced in rats through intraperitoneal injection of 1% streptozotocin. A single nHA/PLLA absorbable screw was surgically implanted into the medial tibia of each rat in both groups. Rats were euthanized at 4 weeks, 8 weeks and 12 weeks post-implantation, and tissue specimens were subjected to histological, histomorphological, Micro-CT scan, biomechanical, microindentation mechanical testing of trabeculae bone, Raman spectroscopy, and Western blot analyses. Changes in bone mass, trabeculae structure, composition, mechanical properties, and expression of bone formation-related proteins around the absorbable screws were compared between the two groups at the microscopic, biomechanical, and molecular levels. The results show that DM disrupts the trabeculae structure surrounding absorbable screws, leading to alterations in trabeculae bone composition, diminished mechanical properties, and impaired bone metabolism. DM significantly compromises osseointegration at the absorbable screw-bone interface and diminishes bone quality in the vicinity of the absorbable screw. |
| first_indexed | 2025-11-15T01:03:39Z |
| format | Article |
| id | oai:generic.eprints.org:25212 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:03:39Z |
| publishDate | 2025 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:252122025-05-09T08:43:52Z http://journalarticle.ukm.my/25212/ The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation Wu, Zelin Xiao, Lei Hou, Huige Li, Ling Gao, Yanping Guan, Jian Chen, Jiwen Zeng, Lingfeng Chen, Zihang Mok, Tsz-Ngai Miao, Guiqiang Zheng, Xiaofei Yuan, Shiguo Wang, Huajun This study aims to explore the correlation between alterations in blood glucose levels and the osseointegration as well as biomechanical properties of nHA/PLLA absorbable screws, and elucidate the impact of DM on bone metabolism surrounding nHA/PLLA absorbable screws. 75 rats were randomly assigned to either the Diabetes mellitus (DM) group and the control group. DM was induced in rats through intraperitoneal injection of 1% streptozotocin. A single nHA/PLLA absorbable screw was surgically implanted into the medial tibia of each rat in both groups. Rats were euthanized at 4 weeks, 8 weeks and 12 weeks post-implantation, and tissue specimens were subjected to histological, histomorphological, Micro-CT scan, biomechanical, microindentation mechanical testing of trabeculae bone, Raman spectroscopy, and Western blot analyses. Changes in bone mass, trabeculae structure, composition, mechanical properties, and expression of bone formation-related proteins around the absorbable screws were compared between the two groups at the microscopic, biomechanical, and molecular levels. The results show that DM disrupts the trabeculae structure surrounding absorbable screws, leading to alterations in trabeculae bone composition, diminished mechanical properties, and impaired bone metabolism. DM significantly compromises osseointegration at the absorbable screw-bone interface and diminishes bone quality in the vicinity of the absorbable screw. Penerbit Universiti Kebangsaan Malaysia 2025 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/25212/1/SMD%2017.pdf Wu, Zelin and Xiao, Lei and Hou, Huige and Li, Ling and Gao, Yanping and Guan, Jian and Chen, Jiwen and Zeng, Lingfeng and Chen, Zihang and Mok, Tsz-Ngai and Miao, Guiqiang and Zheng, Xiaofei and Yuan, Shiguo and Wang, Huajun (2025) The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation. Sains Malaysiana, 54 (3). pp. 827-838. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol54num3_2025/contentsVol54num3_2025.html |
| spellingShingle | Wu, Zelin Xiao, Lei Hou, Huige Li, Ling Gao, Yanping Guan, Jian Chen, Jiwen Zeng, Lingfeng Chen, Zihang Mok, Tsz-Ngai Miao, Guiqiang Zheng, Xiaofei Yuan, Shiguo Wang, Huajun The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation |
| title | The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation |
| title_full | The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation |
| title_fullStr | The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation |
| title_full_unstemmed | The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation |
| title_short | The impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation |
| title_sort | impact of diabetes mellitus on the osseointegration of absorbable screws: an animal experimental investigation |
| url | http://journalarticle.ukm.my/25212/ http://journalarticle.ukm.my/25212/ http://journalarticle.ukm.my/25212/1/SMD%2017.pdf |