Angiogenesis effects of dental stem cells cultured on polymer scaffolds
Following the PRISMA-ScR guidelines, three electronic databases were searched (PubMed, Scopus and Web of Science) to identify the related studies using specific keywords and terms. The abstracts were evaluated for inclusion and exclusion criteria. The included publications were descriptively analyse...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2025
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| Online Access: | http://journalarticle.ukm.my/25061/ http://journalarticle.ukm.my/25061/1/SSB%2011.pdf |
| _version_ | 1848816257957101568 |
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| author | Nur Najmi Ma, Noor Hasila Ad, Fazren Azmi, Thanaphum Osathanon, Rohaya Megat Abdul Wahab, Farinawati Yazid, |
| author_facet | Nur Najmi Ma, Noor Hasila Ad, Fazren Azmi, Thanaphum Osathanon, Rohaya Megat Abdul Wahab, Farinawati Yazid, |
| author_sort | Nur Najmi Ma, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Following the PRISMA-ScR guidelines, three electronic databases were searched (PubMed, Scopus and Web of Science) to identify the related studies using specific keywords and terms. The abstracts were evaluated for inclusion and exclusion criteria. The included publications were descriptively analysed. Out of 296 articles found, only nine were included for analysis. The objective of this study was to assess the angiogenesis effects of dental stem cells cultured in a polymer scaffold by evaluating their ability to promote blood vessel formation, cell viability, and tissue regeneration, thereby providing insights into their potential therapeutic applications in regenerative medicine. Previous studies mainly focused on polymer scaffold research, neglecting the crucial aspect of angiogenesis in pulp regeneration. Despite DPSCs' versatility in bone regeneration, more research is needed to understand their relationship with angiogenesis. The untapped potential of DPSCs in promoting blood vessel formation and tissue regeneration requires further exploration. Limited investigation exists on how the combination of stem cell, angiogenic, and dentin markers affects angiogenesis in DPSCs. The morphological changes DPSCs undergo in scaffold environments and the gene/protein expression analyses in DPSCs on scaffolds with angiogenic factors are areas that still need exploration. This research gap holds promise for enhanced understanding and advancement in tissue engineering and regenerative medicine, particularly in DPSCs' connection with scaffolds and angiogenesis. There has been limited research on the interplay of DPSCs, polymer scaffolds, and angiogenesis, with unexplored combined consequences on tissue regeneration. Scaffold-based techniques to investigate angiogenesis with DPSCs are uncommon. Further research might transform tissue engineering and regenerative medicine, spanning beyond dentistry. |
| first_indexed | 2025-11-15T01:03:00Z |
| format | Article |
| id | oai:generic.eprints.org:25061 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:03:00Z |
| publishDate | 2025 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:250612025-04-08T07:06:24Z http://journalarticle.ukm.my/25061/ Angiogenesis effects of dental stem cells cultured on polymer scaffolds Nur Najmi Ma, Noor Hasila Ad, Fazren Azmi, Thanaphum Osathanon, Rohaya Megat Abdul Wahab, Farinawati Yazid, Following the PRISMA-ScR guidelines, three electronic databases were searched (PubMed, Scopus and Web of Science) to identify the related studies using specific keywords and terms. The abstracts were evaluated for inclusion and exclusion criteria. The included publications were descriptively analysed. Out of 296 articles found, only nine were included for analysis. The objective of this study was to assess the angiogenesis effects of dental stem cells cultured in a polymer scaffold by evaluating their ability to promote blood vessel formation, cell viability, and tissue regeneration, thereby providing insights into their potential therapeutic applications in regenerative medicine. Previous studies mainly focused on polymer scaffold research, neglecting the crucial aspect of angiogenesis in pulp regeneration. Despite DPSCs' versatility in bone regeneration, more research is needed to understand their relationship with angiogenesis. The untapped potential of DPSCs in promoting blood vessel formation and tissue regeneration requires further exploration. Limited investigation exists on how the combination of stem cell, angiogenic, and dentin markers affects angiogenesis in DPSCs. The morphological changes DPSCs undergo in scaffold environments and the gene/protein expression analyses in DPSCs on scaffolds with angiogenic factors are areas that still need exploration. This research gap holds promise for enhanced understanding and advancement in tissue engineering and regenerative medicine, particularly in DPSCs' connection with scaffolds and angiogenesis. There has been limited research on the interplay of DPSCs, polymer scaffolds, and angiogenesis, with unexplored combined consequences on tissue regeneration. Scaffold-based techniques to investigate angiogenesis with DPSCs are uncommon. Further research might transform tissue engineering and regenerative medicine, spanning beyond dentistry. Penerbit Universiti Kebangsaan Malaysia 2025 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/25061/1/SSB%2011.pdf Nur Najmi Ma, and Noor Hasila Ad, and Fazren Azmi, and Thanaphum Osathanon, and Rohaya Megat Abdul Wahab, and Farinawati Yazid, (2025) Angiogenesis effects of dental stem cells cultured on polymer scaffolds. Sains Malaysiana, 54 (1). pp. 131-150. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol54num1_2025/contentsVol54num1_2025.html |
| spellingShingle | Nur Najmi Ma, Noor Hasila Ad, Fazren Azmi, Thanaphum Osathanon, Rohaya Megat Abdul Wahab, Farinawati Yazid, Angiogenesis effects of dental stem cells cultured on polymer scaffolds |
| title | Angiogenesis effects of dental stem cells cultured on polymer scaffolds |
| title_full | Angiogenesis effects of dental stem cells cultured on polymer scaffolds |
| title_fullStr | Angiogenesis effects of dental stem cells cultured on polymer scaffolds |
| title_full_unstemmed | Angiogenesis effects of dental stem cells cultured on polymer scaffolds |
| title_short | Angiogenesis effects of dental stem cells cultured on polymer scaffolds |
| title_sort | angiogenesis effects of dental stem cells cultured on polymer scaffolds |
| url | http://journalarticle.ukm.my/25061/ http://journalarticle.ukm.my/25061/ http://journalarticle.ukm.my/25061/1/SSB%2011.pdf |