Gender differences in clinical characteristics of rheumatoid arthritis
The most prevalent type of autoimmune inflammatory arthritis is rheumatoid arthritis (RA). Sex hormones are strongly associated in the pathogenesis and progression of RA. Hence, the core objective of this study was to compare the clinical features of RA among men and women. We consecutively recruite...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Penerbit UKM
2023
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| Online Access: | http://journalarticle.ukm.my/24395/ http://journalarticle.ukm.my/24395/1/MH_7pdf_.pdf |
| _version_ | 1848816092327182336 |
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| author | Sakthiswary R, Veshaaliini UR, Syahrul Sazliyana S, |
| author_facet | Sakthiswary R, Veshaaliini UR, Syahrul Sazliyana S, |
| author_sort | Sakthiswary R, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The most prevalent type of autoimmune inflammatory arthritis is rheumatoid arthritis (RA). Sex hormones are strongly associated in the pathogenesis and progression of RA. Hence, the core objective of this study was to compare the clinical features of RA among men and women. We consecutively recruited 23 men and 23 age-matched women with RA from our rheumatology clinic. Subjects were evaluated for their disease activities, radiographic joint damages and functional capacities. The above assessment was performed using DAS-28, Modified Sharp Score (MSS) and European League Against Rheumatism (EULAR) response criteria; respectively. The mean age for the male and female patients were 60.87 + 12.5 and 60.70 + 11.73, respectively. We found that the female subjects had significantly higher c-reactive protein (CRP) levels (p=0.05). The HAQ-DI(p<0.02) and MSS scores (p<0.001) of women were substantially higher than those of males. HAQ-DI and MSS remained to be independently associated with female gender in multivariate analysis, with p values of 0.017 and 0.014, respectively. The findings of this study suggested that in RA, compared to men, women had more severe joint damage and functional disability. |
| first_indexed | 2025-11-15T01:00:22Z |
| format | Article |
| id | oai:generic.eprints.org:24395 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:00:22Z |
| publishDate | 2023 |
| publisher | Penerbit UKM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:243952024-10-18T07:38:50Z http://journalarticle.ukm.my/24395/ Gender differences in clinical characteristics of rheumatoid arthritis Sakthiswary R, Veshaaliini UR, Syahrul Sazliyana S, The most prevalent type of autoimmune inflammatory arthritis is rheumatoid arthritis (RA). Sex hormones are strongly associated in the pathogenesis and progression of RA. Hence, the core objective of this study was to compare the clinical features of RA among men and women. We consecutively recruited 23 men and 23 age-matched women with RA from our rheumatology clinic. Subjects were evaluated for their disease activities, radiographic joint damages and functional capacities. The above assessment was performed using DAS-28, Modified Sharp Score (MSS) and European League Against Rheumatism (EULAR) response criteria; respectively. The mean age for the male and female patients were 60.87 + 12.5 and 60.70 + 11.73, respectively. We found that the female subjects had significantly higher c-reactive protein (CRP) levels (p=0.05). The HAQ-DI(p<0.02) and MSS scores (p<0.001) of women were substantially higher than those of males. HAQ-DI and MSS remained to be independently associated with female gender in multivariate analysis, with p values of 0.017 and 0.014, respectively. The findings of this study suggested that in RA, compared to men, women had more severe joint damage and functional disability. Penerbit UKM 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/24395/1/MH_7pdf_.pdf Sakthiswary R, and Veshaaliini UR, and Syahrul Sazliyana S, (2023) Gender differences in clinical characteristics of rheumatoid arthritis. Medicine & Health, 18 (2). pp. 413-420. ISSN 1823-2140 https://medicineandhealthukm.com/sites/medicineandhealthukm.com/files/article/2023/7_mh_2023_0001_pdf_14057.pdf |
| spellingShingle | Sakthiswary R, Veshaaliini UR, Syahrul Sazliyana S, Gender differences in clinical characteristics of rheumatoid arthritis |
| title | Gender differences in clinical characteristics of rheumatoid arthritis |
| title_full | Gender differences in clinical characteristics of rheumatoid arthritis |
| title_fullStr | Gender differences in clinical characteristics of rheumatoid arthritis |
| title_full_unstemmed | Gender differences in clinical characteristics of rheumatoid arthritis |
| title_short | Gender differences in clinical characteristics of rheumatoid arthritis |
| title_sort | gender differences in clinical characteristics of rheumatoid arthritis |
| url | http://journalarticle.ukm.my/24395/ http://journalarticle.ukm.my/24395/ http://journalarticle.ukm.my/24395/1/MH_7pdf_.pdf |