Synthesis, molecular docking and heme detoxification of pyrano[2,3-c]pyrazoleaminoquinoline hybrids as potential antimalarial agents

QR Code

Synthesis, molecular docking and heme detoxification of pyrano[2,3-c]pyrazoleaminoquinoline hybrids as potential antimalarial agents

Malaria, an infectious disease that spreads widely and can kill people, is still a problem for global health. This study adds to the list of possible solutions by making a group of new pyrano[2,3-c]pyrazole-aminoquinoline hybrids. Here, five novel hybrids were synthesized by covalently linking the s...

Full description

Bibliographic Details
Main Authors:	Lekkala Ravindar, Ng, Yan Hong, Khairul Azreena Bakar, Ahmad Fadhlurrahman Ahmad Hidayat, Shevin Rizal Feroz, Raheem, Saki, Siti Aishah Hasbullah, Nurul Izzaty Hassan
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2024
Online Access:	http://journalarticle.ukm.my/24364/ http://journalarticle.ukm.my/24364/1/SL%2018.pdf

Similar Items

Exploring the interactions of therapeutic phytochemicals, flavokawain b, pinostrobin and 6-shogaol with human serum albumin: Spectroscopic and molecular docking investigations / Shevin Rizal Feroz
by: Shevin Rizal, Feroz
Published: (2017)

Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
by: Noraisyah Abdul Kadir Jilani,, et al.
Published: (2023)

Structural requirements of flavonoids to induce heme oxygenase-1 expression
by: Croft, K., et al.
Published: (2017)

Synthesis, antimalarial activities of secondary amine-substituted eugenol compounds against plasmodium falciparum and in silico molecular docking analysis
by: Syahri, Jufrizal, et al.
Published: (2023)

Detoxification related genes in gut of Coptotermes curvignathus
by: Charles, Suliana, et al.
Published: (2014)

The effect of cooking method on proximate composition, total iron, heme iron and non-heme iron in haruan (channa sp.), catfish ( clariassp,), siakap (lates CALCARIFER) and tilapia (Oreochromis sp.)
by: Anuar, Siti Nadia
Published: (2015)

Design, synthesis and biological evaluation of aminoalkylated chalcones as antimalarial agent
by: Syahri, Jufrizal, et al.
Published: (2020)

Clinical Pharmacology Of Antimalarial Drugs.
Published: (1989)

Quantum chemical calculations of tryptophan→heme electron and excitation energy transfer rates in myoglobin
by: Suess, Christian J., et al.
Published: (2017)

A grounded study of the experience of detoxification from psychoactive drugs.
by: Bartu, Anne
Published: (1998)

Balanced globin protein expression and heme biosynthesis improve production of human hemoglobin in Saccharomyces cerevisiae
by: Liu, Lifang, et al.
Published: (2014)

The synthesis of the antimalarial compound hydroxypiperaquine (HPQ)
by: Mohammed, Yousuf Hussain
Published: (2007)

Pharmacokinetics and allometric scaling of antimalarial drugs
by: Senarathna, Senarathna Mudiyanselage Dona Kalyani Ganga
Published: (2015)

Identification Of Antimalarial Compounds And Their Mode Of Actions
by: Mahmud, Fauze
Published: (2022)

Detoxification of sago trunk hydrolysate using activated charcoal for xylitol production.
by: Mustapa Kamal, Siti Mazlina, et al.
Published: (2011)

Prospect of Fe non-heme on coffee flour made from solid coffee waste: Mini review
by: Setyobud, Roy Hendroko, et al.
Published: (2019)

Characterisation of caprine islet-related genes and enhancement of islet viability and function by heme oxygenase 1 gene
by: Vakhshiteh, Faezeh
Published: (2013)

Anti-diabetic activity of Leptospermum flavescens leaves using in vitro and in vivo models / Ahmad Fadhlurrahman Ahmad Hidayat
by: Ahmad Fadhlurrahman , Ahmad Hidayat
Published: (2018)

Synthesis, antimalarial activity, and molecular dynamic approaches of salophen metal complexes
by: Ali, Amatul Hamizah, et al.
Published: (2024)

The candidate antimalarial drug MMV665909 causes oxygen-dependent mRNA mistranslation and synergises with quinoline-derived antimalarials
by: Vallieres, Cindy, et al.
Published: (2017)

Complications with remediation strategies involving the biodegradation and detoxification of recalcitrant contaminant aromatic hydrocarbons
by: Frenzel, M., et al.
Published: (2010)

Characterization of linamarin-utilizing bacterial strains associated with detoxification of cyanogens in waste effluents
by: Adewale K., Ogunyemi, et al.
Published: (2019)

Systematic review: detoxification of free radicals from ionizing radiation with glutathione intake
by: Rachman, Rizaldy Fathur, et al.
Published: (2022)

Biological detoxification of Cr(VI) using wood-husk immobilized Acinetobacter haemolyticus
by: Zakaria, Zainul Akmar, et al.
Published: (2007)

Antimalarial activity of Neopetrosia exigua extract in mice
by: Abdillah, Syamsudin, et al.
Published: (2013)

Synthesis and antimalarial evaluation of novel isocryptolepine derivatives
by: Whittell, Louise, et al.
Published: (2011)

A new method to image heme-Fe, total Fe, and aggregated protein levels after intracerebral hemorrhage
by: Hackett, Mark, et al.
Published: (2015)

Prediction of the performance of a solar water detoxification system under Malaysian climatic conditions
by: Jubran, B.A., et al.
Published: (2000)

Microbial detoxification of gadung (Dioscorea hispida Dennst) chips: Effect of microbes loading and time
by: Kumoro, Andri Cahyo, et al.
Published: (2020)

The antimalarial drug quinine interferes with serotonin biosynthesis and action
by: Islahudin, Farida, et al.
Published: (2014)

Role of P-glycoprotein in absorption of novel antimalarial drugs
by: Crowe, Andrew, et al.
Published: (2006)

Relationship between WQI, heavy metal and sedimentation in Sg Kenau, Kuantan, Pahang using WQ-HeMeS Model
by: Nadiatul Adilah, Ahmad Abdul Ghani, et al.
Published: (2021)

Detoxification of Jatropha curcas seeds through solid state fermentation (SSF) by using Aspergillus niger
by: Ahmad, Sharmila, et al.
Published: (2011)

Molecular docking
by: Abduallah Alsafi, Hassen Mohammed, et al.
Published: (2011)

Pharmacodynamic studies of antimalarial drugs in a murine malaria model
by: Moore, Brioni R.
Published: (2011)

In-vivo antimalarial activity of the endophytic actinobacterium, Streptomyces SUK 10
by: Baba, Mohd Shukri, et al.
Published: (2015)

Application of yeast to understanding the mode of action of the antimalarial drug artesunate
by: Wilson, Jonathan M.
Published: (2014)

Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine
by: Islahudin, Farida, et al.
Published: (2013)

Effect of some antimalarial drugs on the liver: biochemical and histopathological studies
by: Al-Ani, Imad Matloub Dally, et al.
Published: (2013)

Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei
by: Ramli, Norazsida, et al.
Published: (2014)