Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira
Leptospirosis is one of the often-neglected fatal zoonotic diseases endemic to most developing countries. The disease transmits mostly through contact of rodent urine contaminated with pathogenic Leptospira in the environment. This review discusses the need for environmental bioremediation of these...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2024
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| Online Access: | http://journalarticle.ukm.my/23981/ http://journalarticle.ukm.my/23981/1/MAD%201.pdf |
| _version_ | 1848815983838363648 |
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| author | Kokxin, Fang Norefrina Shafinaz Md Nor, |
| author_facet | Kokxin, Fang Norefrina Shafinaz Md Nor, |
| author_sort | Kokxin, Fang |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Leptospirosis is one of the often-neglected fatal zoonotic diseases endemic to most developing countries. The disease transmits mostly through contact of rodent urine contaminated with pathogenic Leptospira in the environment. This review discusses the need for environmental bioremediation of these pathogens and the reasons phage could very well be employed for that purpose. With a few modifications like encapsulation and cocktail formulation, the functionality and stability of phage as the natural predator could easily be heightened. Host specificity, ability to auto-dose and co-evolve along its hosts, effectiveness against biofilms and independence of its production are some of the promising features of a phage. Here we also highlight the interactions and interference among phages in a cocktail, transduction probability, and hypothetic usage of phage lysin in biocontrolling pathogenic Leptospira. |
| first_indexed | 2025-11-15T00:58:39Z |
| format | Article |
| id | oai:generic.eprints.org:23981 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:58:39Z |
| publishDate | 2024 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:239812024-08-09T01:59:32Z http://journalarticle.ukm.my/23981/ Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira Kokxin, Fang Norefrina Shafinaz Md Nor, Leptospirosis is one of the often-neglected fatal zoonotic diseases endemic to most developing countries. The disease transmits mostly through contact of rodent urine contaminated with pathogenic Leptospira in the environment. This review discusses the need for environmental bioremediation of these pathogens and the reasons phage could very well be employed for that purpose. With a few modifications like encapsulation and cocktail formulation, the functionality and stability of phage as the natural predator could easily be heightened. Host specificity, ability to auto-dose and co-evolve along its hosts, effectiveness against biofilms and independence of its production are some of the promising features of a phage. Here we also highlight the interactions and interference among phages in a cocktail, transduction probability, and hypothetic usage of phage lysin in biocontrolling pathogenic Leptospira. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/23981/1/MAD%201.pdf Kokxin, Fang and Norefrina Shafinaz Md Nor, (2024) Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira. Malaysian Applied Biology, 53 (2). pp. 1-20. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/59 |
| spellingShingle | Kokxin, Fang Norefrina Shafinaz Md Nor, Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira |
| title | Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira |
| title_full | Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira |
| title_fullStr | Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira |
| title_full_unstemmed | Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira |
| title_short | Encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira |
| title_sort | encapsulated phage cocktail: the destined environmental biocontrol agent for pathogenic leptospira |
| url | http://journalarticle.ukm.my/23981/ http://journalarticle.ukm.my/23981/ http://journalarticle.ukm.my/23981/1/MAD%201.pdf |