Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential
Breast cancer is a prevalent cause of global mortality, characterised by abnormal cell growth within the breast. These cells can spread to distant sites in the body through metastasis and one of the mechanisms that breast cancer cells use to metastasise is via invadopodia formation. Accumulated evid...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/23362/ http://journalarticle.ukm.my/23362/1/SD%2013.pdf |
| _version_ | 1848815827257655296 |
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| author | Nur Aqilah Huda Ahmad Jamil, Chong, Sylvia Hoongli Nurul Akmaryanti Abdullah, Noraina Mohamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Manraj Singh Cheema, Nur Fariesha Md Hashim, |
| author_facet | Nur Aqilah Huda Ahmad Jamil, Chong, Sylvia Hoongli Nurul Akmaryanti Abdullah, Noraina Mohamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Manraj Singh Cheema, Nur Fariesha Md Hashim, |
| author_sort | Nur Aqilah Huda Ahmad Jamil, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Breast cancer is a prevalent cause of global mortality, characterised by abnormal cell growth within the breast. These cells can spread to distant sites in the body through metastasis and one of the mechanisms that breast cancer cells use to metastasise is via invadopodia formation. Accumulated evidence has explained pathways that may contribute to the breast cancer cells metastasis including the ERK, SMAD-3, STAT3 and NF-κB pathways. The hypoxic conditions within tumours enhance their metastatic ability through HIF-1α upregulation. Despite advanced treatments including chemotherapy and radiotherapy, these approaches are expensive and sometimes lack efficacy. Zerumbone, a compound extracted from Zingiber zerumbet, is known for its anti-cancer properties. It counteracts cancer cell metastasis by reducing cell migration, invasion, and proliferation by acting upon multiple signalling pathways. This review recapitulates the metastasis of breast cancer and its biomarkers. In addition, our review will also explore the impact of zerumbone, therapeutic roles and its mechanism of action in reducing breast cancer metastasis. |
| first_indexed | 2025-11-15T00:56:10Z |
| format | Article |
| id | oai:generic.eprints.org:23362 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:56:10Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:233622024-04-19T03:18:49Z http://journalarticle.ukm.my/23362/ Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential Nur Aqilah Huda Ahmad Jamil, Chong, Sylvia Hoongli Nurul Akmaryanti Abdullah, Noraina Mohamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Manraj Singh Cheema, Nur Fariesha Md Hashim, Breast cancer is a prevalent cause of global mortality, characterised by abnormal cell growth within the breast. These cells can spread to distant sites in the body through metastasis and one of the mechanisms that breast cancer cells use to metastasise is via invadopodia formation. Accumulated evidence has explained pathways that may contribute to the breast cancer cells metastasis including the ERK, SMAD-3, STAT3 and NF-κB pathways. The hypoxic conditions within tumours enhance their metastatic ability through HIF-1α upregulation. Despite advanced treatments including chemotherapy and radiotherapy, these approaches are expensive and sometimes lack efficacy. Zerumbone, a compound extracted from Zingiber zerumbet, is known for its anti-cancer properties. It counteracts cancer cell metastasis by reducing cell migration, invasion, and proliferation by acting upon multiple signalling pathways. This review recapitulates the metastasis of breast cancer and its biomarkers. In addition, our review will also explore the impact of zerumbone, therapeutic roles and its mechanism of action in reducing breast cancer metastasis. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/23362/1/SD%2013.pdf Nur Aqilah Huda Ahmad Jamil, and Chong, Sylvia Hoongli and Nurul Akmaryanti Abdullah, and Noraina Mohamad Zakuan, and Hafizah Abdul Hamid, and Muhammad Zulfadli Mehat, and Manraj Singh Cheema, and Nur Fariesha Md Hashim, (2023) Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential. Sains Malaysiana, 52 (12). pp. 3511-3522. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol52num12_2023/contentsVol52num12_2023.html |
| spellingShingle | Nur Aqilah Huda Ahmad Jamil, Chong, Sylvia Hoongli Nurul Akmaryanti Abdullah, Noraina Mohamad Zakuan, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Manraj Singh Cheema, Nur Fariesha Md Hashim, Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential |
| title | Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential |
| title_full | Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential |
| title_fullStr | Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential |
| title_full_unstemmed | Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential |
| title_short | Zerumbone: a potent emerging phytochemical with anticancer therapeutic potential |
| title_sort | zerumbone: a potent emerging phytochemical with anticancer therapeutic potential |
| url | http://journalarticle.ukm.my/23362/ http://journalarticle.ukm.my/23362/ http://journalarticle.ukm.my/23362/1/SD%2013.pdf |