Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats
Nonsteroidal anti-inflammatory drugs (NSAIDs) potentially induce hepatotoxicity and ulcerative lesions in the stomach. Several studies have been conducted on the benefits of natural resources to overcome the problem of drug side effects. However, the use of fishery resources, such as the eel (Anguil...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/23328/ http://journalarticle.ukm.my/23328/1/SS%208.pdf |
| _version_ | 1848815817427255296 |
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| author | Sasongko, Heru Brilian, Aulia Yulfa Octafiani, Hardiana Fega Alfasina, Nabila Rachma Cahyadi, Muhammad Sutarno, |
| author_facet | Sasongko, Heru Brilian, Aulia Yulfa Octafiani, Hardiana Fega Alfasina, Nabila Rachma Cahyadi, Muhammad Sutarno, |
| author_sort | Sasongko, Heru |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs) potentially induce hepatotoxicity and ulcerative lesions in the stomach. Several studies have been conducted on the benefits of natural resources to overcome the problem of drug side effects. However, the use of fishery resources, such as the eel (Anguilla bicolor), for medicine has not been widely studied. Eels are rich in omega-3 polyunsaturated fatty acids with antioxidant and anti-inflammatory effects. Therefore, this study aims to determine the gastroprotective and hepatoprotective effects of polyunsaturated fatty acids extracted from eel (FaE). The experimental models were 42 male rats divided into seven groups. The experiment was performed for 14 days by orally administering FaE samples. On the 15th day, the rats were orally induced with indomethacin (48 mg/kg). After 8 h of induction, they were euthanized using ketamine and xylazine. Furthermore, blood samples were collected from the animals to measure the levels of aspartate aminotransferase and alanine aminotransferase. Malondialdehyde (MDA) and glutathione (GSH) levels were measured, while the histology of the liver and stomach were examined. The results showed that the administration of FaE from a dose of 1000 mg/ kg significantly attenuated the liver and stomach damage caused by indomethacin. The influence of oxidative stress inhibition on damage is characterized by inhibition of the increase in MDA and a decrease in GSH. This research shows that FaE has the potential to inhibit liver and gastric damage due to the use of NSAIDs. However, further investigation needs to be conducted on other specific parameters of the inflammatory mechanism. |
| first_indexed | 2025-11-15T00:56:00Z |
| format | Article |
| id | oai:generic.eprints.org:23328 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:56:00Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:233282024-04-03T00:54:32Z http://journalarticle.ukm.my/23328/ Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats Sasongko, Heru Brilian, Aulia Yulfa Octafiani, Hardiana Fega Alfasina, Nabila Rachma Cahyadi, Muhammad Sutarno, Nonsteroidal anti-inflammatory drugs (NSAIDs) potentially induce hepatotoxicity and ulcerative lesions in the stomach. Several studies have been conducted on the benefits of natural resources to overcome the problem of drug side effects. However, the use of fishery resources, such as the eel (Anguilla bicolor), for medicine has not been widely studied. Eels are rich in omega-3 polyunsaturated fatty acids with antioxidant and anti-inflammatory effects. Therefore, this study aims to determine the gastroprotective and hepatoprotective effects of polyunsaturated fatty acids extracted from eel (FaE). The experimental models were 42 male rats divided into seven groups. The experiment was performed for 14 days by orally administering FaE samples. On the 15th day, the rats were orally induced with indomethacin (48 mg/kg). After 8 h of induction, they were euthanized using ketamine and xylazine. Furthermore, blood samples were collected from the animals to measure the levels of aspartate aminotransferase and alanine aminotransferase. Malondialdehyde (MDA) and glutathione (GSH) levels were measured, while the histology of the liver and stomach were examined. The results showed that the administration of FaE from a dose of 1000 mg/ kg significantly attenuated the liver and stomach damage caused by indomethacin. The influence of oxidative stress inhibition on damage is characterized by inhibition of the increase in MDA and a decrease in GSH. This research shows that FaE has the potential to inhibit liver and gastric damage due to the use of NSAIDs. However, further investigation needs to be conducted on other specific parameters of the inflammatory mechanism. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/23328/1/SS%208.pdf Sasongko, Heru and Brilian, Aulia Yulfa and Octafiani, Hardiana Fega and Alfasina, Nabila Rachma and Cahyadi, Muhammad and Sutarno, (2023) Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats. Sains Malaysiana, 52 (10). pp. 2829-2841. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol52num10_2023/contentsVol52num10_2023.html |
| spellingShingle | Sasongko, Heru Brilian, Aulia Yulfa Octafiani, Hardiana Fega Alfasina, Nabila Rachma Cahyadi, Muhammad Sutarno, Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats |
| title | Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats |
| title_full | Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats |
| title_fullStr | Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats |
| title_full_unstemmed | Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats |
| title_short | Polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by Indomethacin-induced in rats |
| title_sort | polyunsaturated fatty acids from eel extract attenuate gastritis and hepatotoxic by indomethacin-induced in rats |
| url | http://journalarticle.ukm.my/23328/ http://journalarticle.ukm.my/23328/ http://journalarticle.ukm.my/23328/1/SS%208.pdf |