Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review
Listeria monocytogenes is a Gram-positive foodborne pathogen capable of causing a foodborne infection known as listeriosis. There are two main types of listeriosis: a non-invasive gastroenteritis and an invasive infection which is often associated with a high mortality and hospitalization rate among...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/23091/ http://journalarticle.ukm.my/23091/1/SMS%2012.pdf |
| _version_ | 1848815758155448320 |
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| author | Hien, Fuh Ng May, Jamie Ling Ng Yun, Fong Ngeow |
| author_facet | Hien, Fuh Ng May, Jamie Ling Ng Yun, Fong Ngeow |
| author_sort | Hien, Fuh Ng |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Listeria monocytogenes is a Gram-positive foodborne pathogen capable of causing a foodborne infection known as listeriosis. There are two main types of listeriosis: a non-invasive gastroenteritis and an invasive infection which is often associated with a high mortality and hospitalization rate among susceptible individuals. Gentamicin, used as an adjunct therapy with ampicillin, remains the treatment of choice for the life-threatening invasive listeriosis. Nevertheless, there is little data on gentamicin resistance determinants in L. monocytogenes. Several well-controlled studies have reported that mechanisms of gentamicin resistance in this organism involve active efflux and genetic determinants that affect the uptake of the antibiotic through altered membrane potential. This mini review summarises current knowledge of genetic determinants of gentamicin resistance in L. monocytogenes, with the aim of contributing information that could facilitate the discovery of new therapeutic approaches to overcome, delay or avoid developments of drug resistance in this foodborne pathogen. |
| first_indexed | 2025-11-15T00:55:04Z |
| format | Article |
| id | oai:generic.eprints.org:23091 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:55:04Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:230912024-02-19T00:50:37Z http://journalarticle.ukm.my/23091/ Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review Hien, Fuh Ng May, Jamie Ling Ng Yun, Fong Ngeow Listeria monocytogenes is a Gram-positive foodborne pathogen capable of causing a foodborne infection known as listeriosis. There are two main types of listeriosis: a non-invasive gastroenteritis and an invasive infection which is often associated with a high mortality and hospitalization rate among susceptible individuals. Gentamicin, used as an adjunct therapy with ampicillin, remains the treatment of choice for the life-threatening invasive listeriosis. Nevertheless, there is little data on gentamicin resistance determinants in L. monocytogenes. Several well-controlled studies have reported that mechanisms of gentamicin resistance in this organism involve active efflux and genetic determinants that affect the uptake of the antibiotic through altered membrane potential. This mini review summarises current knowledge of genetic determinants of gentamicin resistance in L. monocytogenes, with the aim of contributing information that could facilitate the discovery of new therapeutic approaches to overcome, delay or avoid developments of drug resistance in this foodborne pathogen. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/23091/1/SMS%2012.pdf Hien, Fuh Ng and May, Jamie Ling Ng and Yun, Fong Ngeow (2023) Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review. Sains Malaysiana, 52 (9). pp. 2625-2632. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol52num9_2023/contentsVol52num9_2023.html |
| spellingShingle | Hien, Fuh Ng May, Jamie Ling Ng Yun, Fong Ngeow Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review |
| title | Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review |
| title_full | Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review |
| title_fullStr | Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review |
| title_full_unstemmed | Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review |
| title_short | Mechanisms of gentamicin resistance in listeria monocytogenes: a mini review |
| title_sort | mechanisms of gentamicin resistance in listeria monocytogenes: a mini review |
| url | http://journalarticle.ukm.my/23091/ http://journalarticle.ukm.my/23091/ http://journalarticle.ukm.my/23091/1/SMS%2012.pdf |