Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development
Ficus deltoidea (FD) is used in traditional Malay medicine to treat various ailments and has been shown to be safe in toxicity studies. However, the information on the safety and efficacy of FD in the atherosclerosis-induced animal model is limited. This study aims to investigate the safety of FD va...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/22455/ http://journalarticle.ukm.my/22455/1/JM%206.pdf |
| _version_ | 1848815604201422848 |
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| author | Amirah Mohd Ariff, Effat Omar, Suhaila Muid, Noor Alicezah Mohd Kasim, Nor Hadiani Ismail, Hapizah Nawawi, |
| author_facet | Amirah Mohd Ariff, Effat Omar, Suhaila Muid, Noor Alicezah Mohd Kasim, Nor Hadiani Ismail, Hapizah Nawawi, |
| author_sort | Amirah Mohd Ariff, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Ficus deltoidea (FD) is used in traditional Malay medicine to treat various ailments and has been shown to be safe in toxicity studies. However, the information on the safety and efficacy of FD in the atherosclerosis-induced animal model is limited. This study aims to investigate the safety of FD var. kunstleri (FDK) extract on high cholesterol diet (HCD)-induced atherosclerotic rabbits and its efficacy in treating atherosclerosis. New Zealand White rabbits were randomly divided into two groups: G1 (1% HCD for 4 weeks) and G2 (1% HCD for 8 weeks). Each group was randomised into FDK700 (700 mg FDK/kg/day for G1 and G2), FDK800 (800 mg FDK/kg/day for G2), simvastatin (5 mg/kg/day) and placebo. The body weight, blood pressure, serum biochemistry and histopathological examination were obtained to assess any toxicity signs. Fasting lipid profile, soluble c-reactive protein (sCRP) level and atherosclerotic plaque formation were compared between treated and placebo groups to evaluate treatment efficacy. Results: No significant differences were observed in all safety parameters between the treated and placebo groups (p<0.05). FDK treatment did not show significant differences in all parameters evaluated in both treatment arms. In conclusion, FDK extract up to 800 mg/kg is safe for use in atherosclerotic rabbits. It has neutral effects on lipid profile, inflammation and atherosclerosis formation. |
| first_indexed | 2025-11-15T00:52:37Z |
| format | Article |
| id | oai:generic.eprints.org:22455 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:52:37Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:224552023-11-08T08:33:58Z http://journalarticle.ukm.my/22455/ Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development Amirah Mohd Ariff, Effat Omar, Suhaila Muid, Noor Alicezah Mohd Kasim, Nor Hadiani Ismail, Hapizah Nawawi, Ficus deltoidea (FD) is used in traditional Malay medicine to treat various ailments and has been shown to be safe in toxicity studies. However, the information on the safety and efficacy of FD in the atherosclerosis-induced animal model is limited. This study aims to investigate the safety of FD var. kunstleri (FDK) extract on high cholesterol diet (HCD)-induced atherosclerotic rabbits and its efficacy in treating atherosclerosis. New Zealand White rabbits were randomly divided into two groups: G1 (1% HCD for 4 weeks) and G2 (1% HCD for 8 weeks). Each group was randomised into FDK700 (700 mg FDK/kg/day for G1 and G2), FDK800 (800 mg FDK/kg/day for G2), simvastatin (5 mg/kg/day) and placebo. The body weight, blood pressure, serum biochemistry and histopathological examination were obtained to assess any toxicity signs. Fasting lipid profile, soluble c-reactive protein (sCRP) level and atherosclerotic plaque formation were compared between treated and placebo groups to evaluate treatment efficacy. Results: No significant differences were observed in all safety parameters between the treated and placebo groups (p<0.05). FDK treatment did not show significant differences in all parameters evaluated in both treatment arms. In conclusion, FDK extract up to 800 mg/kg is safe for use in atherosclerotic rabbits. It has neutral effects on lipid profile, inflammation and atherosclerosis formation. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/22455/1/JM%206.pdf Amirah Mohd Ariff, and Effat Omar, and Suhaila Muid, and Noor Alicezah Mohd Kasim, and Nor Hadiani Ismail, and Hapizah Nawawi, (2023) Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development. Malaysian Applied Biology, 52 (1). pp. 73-85. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/index |
| spellingShingle | Amirah Mohd Ariff, Effat Omar, Suhaila Muid, Noor Alicezah Mohd Kasim, Nor Hadiani Ismail, Hapizah Nawawi, Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development |
| title | Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development |
| title_full | Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development |
| title_fullStr | Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development |
| title_full_unstemmed | Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development |
| title_short | Ficus deltoidea var. kunstleri extract administration in Hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development |
| title_sort | ficus deltoidea var. kunstleri extract administration in hypercholesterolaemic, atherosclerotic rabbits: effects on organ function, morphology, and atherosclerosis development |
| url | http://journalarticle.ukm.my/22455/ http://journalarticle.ukm.my/22455/ http://journalarticle.ukm.my/22455/1/JM%206.pdf |