Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
In this study, the new compound 6-amidinoindole 3 were synthesized by hydrogenating the amidoxime unit in a high yield. The compound was characterized by FTIR, 1H NMR, 13C NMR and ESI-MS. The binding of the compound towards heme was evaluated using absorption spectroscopy. The studies found that the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/22071/ http://journalarticle.ukm.my/22071/1/SE%2015.pdf |
| _version_ | 1848815509022179328 |
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| author | Noraisyah Abdul Kadir Jilani, Oka, Natsuhisa Ando, Kaori Siti Aishah Hasbullah, |
| author_facet | Noraisyah Abdul Kadir Jilani, Oka, Natsuhisa Ando, Kaori Siti Aishah Hasbullah, |
| author_sort | Noraisyah Abdul Kadir Jilani, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | In this study, the new compound 6-amidinoindole 3 were synthesized by hydrogenating the amidoxime unit in a high yield. The compound was characterized by FTIR, 1H NMR, 13C NMR and ESI-MS. The binding of the compound towards heme was evaluated using absorption spectroscopy. The studies found that the association constant (log K) is 3.90. The binding strength indicated the ligand’s possibility to interact significantly with heme and acted as a binder to the malaria parasite. In silico hemozoin docking was performed to gain insight into the mode of action. The docked score is -8.3 kcal/mol, indicated the possible inhibition of hemozoin. This study could serve as the basis for the future development of malaria sensors and antiplasmodial activity. |
| first_indexed | 2025-11-15T00:51:06Z |
| format | Article |
| id | oai:generic.eprints.org:22071 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:51:06Z |
| publishDate | 2023 |
| publisher | Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:220712023-08-08T08:54:45Z http://journalarticle.ukm.my/22071/ Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder Noraisyah Abdul Kadir Jilani, Oka, Natsuhisa Ando, Kaori Siti Aishah Hasbullah, In this study, the new compound 6-amidinoindole 3 were synthesized by hydrogenating the amidoxime unit in a high yield. The compound was characterized by FTIR, 1H NMR, 13C NMR and ESI-MS. The binding of the compound towards heme was evaluated using absorption spectroscopy. The studies found that the association constant (log K) is 3.90. The binding strength indicated the ligand’s possibility to interact significantly with heme and acted as a binder to the malaria parasite. In silico hemozoin docking was performed to gain insight into the mode of action. The docked score is -8.3 kcal/mol, indicated the possible inhibition of hemozoin. This study could serve as the basis for the future development of malaria sensors and antiplasmodial activity. Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/22071/1/SE%2015.pdf Noraisyah Abdul Kadir Jilani, and Oka, Natsuhisa and Ando, Kaori and Siti Aishah Hasbullah, (2023) Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder. Sains Malaysiana, 52 (4). pp. 1231-1242. ISSN 0126-6039 http://www.ukm.my/jsm/index.html |
| spellingShingle | Noraisyah Abdul Kadir Jilani, Oka, Natsuhisa Ando, Kaori Siti Aishah Hasbullah, Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder |
| title | Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder |
| title_full | Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder |
| title_fullStr | Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder |
| title_full_unstemmed | Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder |
| title_short | Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder |
| title_sort | synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder |
| url | http://journalarticle.ukm.my/22071/ http://journalarticle.ukm.my/22071/ http://journalarticle.ukm.my/22071/1/SE%2015.pdf |