Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
Microalgae are an invaluable source of new and safe therapeutics with potential antiviral and free-radical scavenging compounds. This study aimed to investigate the antiviral and antioxidant properties of local microalgae, Chlorella sp. (UKM8). The UKM8 methanol extract (UKM8-ME) was tested for anti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/21704/ http://journalarticle.ukm.my/21704/1/ML%2014.pdf |
| _version_ | 1848815416883806208 |
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| author | Abdul Fattah Shaima, Nazlina Haiza Mohd Yasin, Nazlina Ibrahim, |
| author_facet | Abdul Fattah Shaima, Nazlina Haiza Mohd Yasin, Nazlina Ibrahim, |
| author_sort | Abdul Fattah Shaima, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Microalgae are an invaluable source of new and safe therapeutics with potential antiviral and free-radical scavenging compounds. This study aimed to investigate the antiviral and antioxidant properties of local microalgae, Chlorella sp. (UKM8). The UKM8 methanol extract (UKM8-ME) was tested for antiviral activity using plaque reduction assay against Human Herpes Virus type 1 (HHV-1). The antioxidant activity of UKM8-ME was evaluated for the radical scavenging activity (RSA) according to the elimination of 1,1-diphenyl-2-pikrilhydrazil (DPPH) radicals and total phenolic content (TPC) by the Folin-Ciocalteu reactions. UKM8-ME effective concentration that inhibits 50% (EC50) of plaque formation was 222.33 ± 24.54 μg/mL. The calculated selective index is 19 indicating potential antiviral activity. In the DPPH assay, the IC50 value of positive control and UKM8-ME were 122.9 ± 29.1 and 198.78 ± 14.35 μg/mL, respectively. The TPC of positive control and UKM8-ME were 263.414 ± 9.6 and 254.793 ± 3.31 mg GAE/g, respectively. Evaluation in RSA and TPC concludes that UKM8-ME has high antioxidant activity. In conclusion, UKM8-ME has two unique properties in anti-HHV-1 and antioxidant activities that can be further evaluated for potential in pharmaceutics and food ingredients. |
| first_indexed | 2025-11-15T00:49:38Z |
| format | Article |
| id | oai:generic.eprints.org:21704 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:49:38Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:217042023-06-08T07:52:55Z http://journalarticle.ukm.my/21704/ Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties Abdul Fattah Shaima, Nazlina Haiza Mohd Yasin, Nazlina Ibrahim, Microalgae are an invaluable source of new and safe therapeutics with potential antiviral and free-radical scavenging compounds. This study aimed to investigate the antiviral and antioxidant properties of local microalgae, Chlorella sp. (UKM8). The UKM8 methanol extract (UKM8-ME) was tested for antiviral activity using plaque reduction assay against Human Herpes Virus type 1 (HHV-1). The antioxidant activity of UKM8-ME was evaluated for the radical scavenging activity (RSA) according to the elimination of 1,1-diphenyl-2-pikrilhydrazil (DPPH) radicals and total phenolic content (TPC) by the Folin-Ciocalteu reactions. UKM8-ME effective concentration that inhibits 50% (EC50) of plaque formation was 222.33 ± 24.54 μg/mL. The calculated selective index is 19 indicating potential antiviral activity. In the DPPH assay, the IC50 value of positive control and UKM8-ME were 122.9 ± 29.1 and 198.78 ± 14.35 μg/mL, respectively. The TPC of positive control and UKM8-ME were 263.414 ± 9.6 and 254.793 ± 3.31 mg GAE/g, respectively. Evaluation in RSA and TPC concludes that UKM8-ME has high antioxidant activity. In conclusion, UKM8-ME has two unique properties in anti-HHV-1 and antioxidant activities that can be further evaluated for potential in pharmaceutics and food ingredients. Penerbit Universiti Kebangsaan Malaysia 2022 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21704/1/ML%2014.pdf Abdul Fattah Shaima, and Nazlina Haiza Mohd Yasin, and Nazlina Ibrahim, (2022) Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties. Malaysian Applied Biology, 51 (5). pp. 153-158. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/index |
| spellingShingle | Abdul Fattah Shaima, Nazlina Haiza Mohd Yasin, Nazlina Ibrahim, Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties |
| title | Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties |
| title_full | Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties |
| title_fullStr | Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties |
| title_full_unstemmed | Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties |
| title_short | Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties |
| title_sort | chlorella sp. (ukm8), a local microalgae isolate with anti-human herpes virus and antioxidant properties |
| url | http://journalarticle.ukm.my/21704/ http://journalarticle.ukm.my/21704/ http://journalarticle.ukm.my/21704/1/ML%2014.pdf |