Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo
The current study envisioned to evaluate time related protective effect of quercetin, alpha lipoic acid and ascorbic acid on liver of mice against sub-acute exposure of zinc oxide (ZnO-NP) nanoparticle. Male Swiss albino mice (n=72) were randomly divided into eight groups (n=9, each group). G1 recei...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2023
|
| Online Access: | http://journalarticle.ukm.my/21621/ http://journalarticle.ukm.my/21621/1/SD%2018.pdf |
| _version_ | 1848815396569743360 |
|---|---|
| author | Sajjad, Sumera Saeed, Laiba Malik, Husna Naseem, Bushra Rashid, Farzana Liaqat, Iram Khalid, Nida Naseem, Amna |
| author_facet | Sajjad, Sumera Saeed, Laiba Malik, Husna Naseem, Bushra Rashid, Farzana Liaqat, Iram Khalid, Nida Naseem, Amna |
| author_sort | Sajjad, Sumera |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The current study envisioned to evaluate time related protective effect of quercetin, alpha lipoic acid and ascorbic acid on liver of mice against sub-acute exposure of zinc oxide (ZnO-NP) nanoparticle. Male Swiss albino mice (n=72) were randomly divided into eight groups (n=9, each group). G1 received saline solution 0.9%; G2 received quercetin (100 mg/kg b.w); G3 received alpha lipoic acid (100 mg/kg b.w); G4 received ascorbic acid (100 mg/kg b.w); G5 received ZnO-NPs (50 mg/kg b.w); G6 received ZnO-NPs with quercetin; G7 received ZnO-NPs with Alpha lipoic acid and G8 co-treated with ZnO-NPs and ascorbic acid for 21 consecutive days. Body weight, hepatosomatic index and plasma biochemical parameters (total protein, albumin, globulin, total cholesterol, triglycerides, high density lipoproteins, low density lipoprotein, aspartate aminotransferase, alanine transaminase, alkaline phosphatase & bilirubin) were estimated. ZnO showed significant increase in body weight and cause alterations in all biochemical parameters. Co-administration of quercetin (100 mg/kg b.w), alpha lipoic acid and ascorbic acid daily along with ZnONPs, significantly ameliorate the dramatic alteration in biochemical parameters and hepatocellular necrosis caused by ZnO nanoparticles. Brine shrimp larvae cytotoxicity assay of ZnO nanoparticles showed 0% mortality. Present study concluded that all three active ingredients showed hepatoprotective effects against nanoparticles induced time dependent toxicity. |
| first_indexed | 2025-11-15T00:49:19Z |
| format | Article |
| id | oai:generic.eprints.org:21621 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:49:19Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:216212023-05-24T12:45:49Z http://journalarticle.ukm.my/21621/ Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo Sajjad, Sumera Saeed, Laiba Malik, Husna Naseem, Bushra Rashid, Farzana Liaqat, Iram Khalid, Nida Naseem, Amna The current study envisioned to evaluate time related protective effect of quercetin, alpha lipoic acid and ascorbic acid on liver of mice against sub-acute exposure of zinc oxide (ZnO-NP) nanoparticle. Male Swiss albino mice (n=72) were randomly divided into eight groups (n=9, each group). G1 received saline solution 0.9%; G2 received quercetin (100 mg/kg b.w); G3 received alpha lipoic acid (100 mg/kg b.w); G4 received ascorbic acid (100 mg/kg b.w); G5 received ZnO-NPs (50 mg/kg b.w); G6 received ZnO-NPs with quercetin; G7 received ZnO-NPs with Alpha lipoic acid and G8 co-treated with ZnO-NPs and ascorbic acid for 21 consecutive days. Body weight, hepatosomatic index and plasma biochemical parameters (total protein, albumin, globulin, total cholesterol, triglycerides, high density lipoproteins, low density lipoprotein, aspartate aminotransferase, alanine transaminase, alkaline phosphatase & bilirubin) were estimated. ZnO showed significant increase in body weight and cause alterations in all biochemical parameters. Co-administration of quercetin (100 mg/kg b.w), alpha lipoic acid and ascorbic acid daily along with ZnONPs, significantly ameliorate the dramatic alteration in biochemical parameters and hepatocellular necrosis caused by ZnO nanoparticles. Brine shrimp larvae cytotoxicity assay of ZnO nanoparticles showed 0% mortality. Present study concluded that all three active ingredients showed hepatoprotective effects against nanoparticles induced time dependent toxicity. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21621/1/SD%2018.pdf Sajjad, Sumera and Saeed, Laiba and Malik, Husna and Naseem, Bushra and Rashid, Farzana and Liaqat, Iram and Khalid, Nida and Naseem, Amna (2023) Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo. Sains Malaysiana, 52 (2). pp. 563-578. ISSN 0126-6039 http://www.ukm.my/jsm/index.html |
| spellingShingle | Sajjad, Sumera Saeed, Laiba Malik, Husna Naseem, Bushra Rashid, Farzana Liaqat, Iram Khalid, Nida Naseem, Amna Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo |
| title | Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo |
| title_full | Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo |
| title_fullStr | Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo |
| title_full_unstemmed | Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo |
| title_short | Ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo |
| title_sort | ameliorative effects of alpha lipoic acid, quercetin and ascorbic acid against zinc oxide nanoparticles induced hepatic damage : in vivo |
| url | http://journalarticle.ukm.my/21621/ http://journalarticle.ukm.my/21621/ http://journalarticle.ukm.my/21621/1/SD%2018.pdf |