A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves
Christia vespertilionis is a plant traditionally used to treat various diseases, including inflammation. This study aims to compare and analyze the anti-inflammatory properties and activities of green and red C. vespertilionis leaves and to determine the correlation between the protease inhibition...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2023
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| Online Access: | http://journalarticle.ukm.my/21546/ http://journalarticle.ukm.my/21546/1/S%2017.pdf |
| _version_ | 1848815378343395328 |
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| author | Izzah Farhah Zambari, Nur Airina Muhamad, Sitti Rahma Abdul Hafid, |
| author_facet | Izzah Farhah Zambari, Nur Airina Muhamad, Sitti Rahma Abdul Hafid, |
| author_sort | Izzah Farhah Zambari, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Christia vespertilionis is a plant traditionally used to treat various diseases, including inflammation. This study aims to compare and analyze the anti-inflammatory properties and activities of green and red C. vespertilionis leaves and
to determine the correlation between the protease inhibition assay and phenolic content. Preliminary phytochemical
analysis showed the presence of alkaloids, tannins, saponins, cardenolides, phenolics, cardiac glycosides, flavonoids, and steroids in green and red leaves. Green leaf had the highest anti-inflammation potential, with a high extraction yield (6.39 ± 0.01%), phenolic content (29.25 ± 0.50 mg) gallic acid equivalent [GAE]/mL), flavonoid content (1.57 ± 0.03 mg quercetin acid equivalent [QE]/mL) and tannin content (22.70 ± 3.15 mg tannic acid equivalent [TAE]/mL). Green leaf contained more anti-inflammatory compounds, including n-hexadecanoic acid, phytol, 9, 12,
15-octadecatrienoic acid (Z, Z, Z)- and squalene. The protease inhibition assay showed that green leaf had anti-inflammatory activity at 66.55 ± 2.59% with the half-maximal inhibitory concentration (IC50) of 284.59 ± 10.63
μg/mL. The green leaf showed a significant positive correlation between the protease inhibition assay and phenolic content, with R2 = 0.6821. We conclude that both green and red C. vespertilionis types have the potential to act as anti-inflammatory agents, but green leaves are preferable. |
| first_indexed | 2025-11-15T00:49:02Z |
| format | Article |
| id | oai:generic.eprints.org:21546 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:49:02Z |
| publishDate | 2023 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:215462023-05-09T03:52:30Z http://journalarticle.ukm.my/21546/ A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves Izzah Farhah Zambari, Nur Airina Muhamad, Sitti Rahma Abdul Hafid, Christia vespertilionis is a plant traditionally used to treat various diseases, including inflammation. This study aims to compare and analyze the anti-inflammatory properties and activities of green and red C. vespertilionis leaves and to determine the correlation between the protease inhibition assay and phenolic content. Preliminary phytochemical analysis showed the presence of alkaloids, tannins, saponins, cardenolides, phenolics, cardiac glycosides, flavonoids, and steroids in green and red leaves. Green leaf had the highest anti-inflammation potential, with a high extraction yield (6.39 ± 0.01%), phenolic content (29.25 ± 0.50 mg) gallic acid equivalent [GAE]/mL), flavonoid content (1.57 ± 0.03 mg quercetin acid equivalent [QE]/mL) and tannin content (22.70 ± 3.15 mg tannic acid equivalent [TAE]/mL). Green leaf contained more anti-inflammatory compounds, including n-hexadecanoic acid, phytol, 9, 12, 15-octadecatrienoic acid (Z, Z, Z)- and squalene. The protease inhibition assay showed that green leaf had anti-inflammatory activity at 66.55 ± 2.59% with the half-maximal inhibitory concentration (IC50) of 284.59 ± 10.63 μg/mL. The green leaf showed a significant positive correlation between the protease inhibition assay and phenolic content, with R2 = 0.6821. We conclude that both green and red C. vespertilionis types have the potential to act as anti-inflammatory agents, but green leaves are preferable. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21546/1/S%2017.pdf Izzah Farhah Zambari, and Nur Airina Muhamad, and Sitti Rahma Abdul Hafid, (2023) A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves. Sains Malaysiana, 52 (1). pp. 211-222. ISSN 0126-6039 http://www.ukm.my/jsm/index.html |
| spellingShingle | Izzah Farhah Zambari, Nur Airina Muhamad, Sitti Rahma Abdul Hafid, A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves |
| title | A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves |
| title_full | A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves |
| title_fullStr | A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves |
| title_full_unstemmed | A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves |
| title_short | A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves |
| title_sort | comparative study of anti-inflammatory properties and activities of green and red christia vespertilionis leaves |
| url | http://journalarticle.ukm.my/21546/ http://journalarticle.ukm.my/21546/ http://journalarticle.ukm.my/21546/1/S%2017.pdf |