Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome
Antihistamine is standard chronic spontaneous urticaria (CSU) therapy. Weight gain is a side effect of concern as prolonged high dose therapy is common. We investigated the effects of 12-weeks loratadine therapy on weight, appetite and parameters of metabolic syndrome (MetS). A cohort study was pe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/21146/ http://journalarticle.ukm.my/21146/1/50854-189413-1-PB.pdf |
| _version_ | 1848815281721311232 |
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| author | Heah, Swee Kuan Adawiyah Jamil, Mohan Arumugam, Tang Min Moon, Norlaila Mustafa, |
| author_facet | Heah, Swee Kuan Adawiyah Jamil, Mohan Arumugam, Tang Min Moon, Norlaila Mustafa, |
| author_sort | Heah, Swee Kuan |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Antihistamine is standard chronic spontaneous urticaria (CSU) therapy. Weight gain is a side effect of concern as prolonged high dose therapy is common. We investigated the effects of 12-weeks loratadine therapy on weight, appetite
and parameters of metabolic syndrome (MetS). A cohort study was performed involving CSU patients aged ≥18 years. Patients with diseases or on drugs affecting weight or appetite were excluded. CSU was treated according to standard
management. Weight, height, waist circumference (WC), body mass index (BMI) and blood pressure (BP), Urticaria Activity Score 7 (UAS7), Dermatology Life Quality Index (DLQI), hunger and satiety questionnaire, fasting blood sugar
(FBS) and fasting lipid profile (FLP) were obtained at baseline, week 6 and week 12. Loratadine cumulative dose were determined. Thirteen (33.33 %) males and 26 (66.67 %) females aged 33.00 (12.00) years participated. Median weight
was 62.55 (18.30) kg, BMI 24.60 (6.80) kg/m2, 13(33.33%) patients had normal weight, 12 (30.77%) overweight, 11 (28.21%) obese and 3 (7.69%) underweight. Significant weight gain was observed at week 6, 67.56 ± 16.14 kg vs 68.16
± 16.95 kg, p < 0.05 and 67.56 ± 16.14 kg vs 64.73 ± 14.60 kg, p = 0.04 at week 12. Changes in BMI, WC, BP, FBS and FLP were insignificant. Three patients developed MetS. Hunger and satiety scores were unaffected. Loratadine induced
weight gain despite no effects on appetite. Weight should be monitored in patients on long term loratadine therapy. |
| first_indexed | 2025-11-15T00:47:29Z |
| format | Article |
| id | oai:generic.eprints.org:21146 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:47:29Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:211462023-02-15T07:13:43Z http://journalarticle.ukm.my/21146/ Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome Heah, Swee Kuan Adawiyah Jamil, Mohan Arumugam, Tang Min Moon, Norlaila Mustafa, Antihistamine is standard chronic spontaneous urticaria (CSU) therapy. Weight gain is a side effect of concern as prolonged high dose therapy is common. We investigated the effects of 12-weeks loratadine therapy on weight, appetite and parameters of metabolic syndrome (MetS). A cohort study was performed involving CSU patients aged ≥18 years. Patients with diseases or on drugs affecting weight or appetite were excluded. CSU was treated according to standard management. Weight, height, waist circumference (WC), body mass index (BMI) and blood pressure (BP), Urticaria Activity Score 7 (UAS7), Dermatology Life Quality Index (DLQI), hunger and satiety questionnaire, fasting blood sugar (FBS) and fasting lipid profile (FLP) were obtained at baseline, week 6 and week 12. Loratadine cumulative dose were determined. Thirteen (33.33 %) males and 26 (66.67 %) females aged 33.00 (12.00) years participated. Median weight was 62.55 (18.30) kg, BMI 24.60 (6.80) kg/m2, 13(33.33%) patients had normal weight, 12 (30.77%) overweight, 11 (28.21%) obese and 3 (7.69%) underweight. Significant weight gain was observed at week 6, 67.56 ± 16.14 kg vs 68.16 ± 16.95 kg, p < 0.05 and 67.56 ± 16.14 kg vs 64.73 ± 14.60 kg, p = 0.04 at week 12. Changes in BMI, WC, BP, FBS and FLP were insignificant. Three patients developed MetS. Hunger and satiety scores were unaffected. Loratadine induced weight gain despite no effects on appetite. Weight should be monitored in patients on long term loratadine therapy. Penerbit Universiti Kebangsaan Malaysia 2022-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21146/1/50854-189413-1-PB.pdf Heah, Swee Kuan and Adawiyah Jamil, and Mohan Arumugam, and Tang Min Moon, and Norlaila Mustafa, (2022) Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome. Jurnal Sains Kesihatan Malaysia, 20 (2). pp. 139-149. ISSN 1675-8161 https://ejournals.ukm.my/jskm/issue/view/1403 |
| spellingShingle | Heah, Swee Kuan Adawiyah Jamil, Mohan Arumugam, Tang Min Moon, Norlaila Mustafa, Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome |
| title | Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome |
| title_full | Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome |
| title_fullStr | Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome |
| title_full_unstemmed | Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome |
| title_short | Chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome |
| title_sort | chronic spontaneous urticaria in adult patients : evaluating the effect of loratadine on weight and metabolic syndrome |
| url | http://journalarticle.ukm.my/21146/ http://journalarticle.ukm.my/21146/ http://journalarticle.ukm.my/21146/1/50854-189413-1-PB.pdf |