Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design
The powder of mixed fruits that are Lemon (Citrus limon) and Red Pitaya (Hylocereus polyrhizus) was used as a nutritional supplement in tablet form for nutraceutical application. D-optimal mixture experimental design (D-Optimal MED) was employed to investigate the influence of different componen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/20877/ http://journalarticle.ukm.my/20877/1/19.pdf |
| _version_ | 1848815219660292096 |
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| author | Ezzah Abd Manan, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Mohd Izuan Effendi Halmi, |
| author_facet | Ezzah Abd Manan, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Mohd Izuan Effendi Halmi, |
| author_sort | Ezzah Abd Manan, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The powder of mixed fruits that are Lemon (Citrus limon) and Red Pitaya (Hylocereus polyrhizus) was used as
a nutritional supplement in tablet form for nutraceutical application. D-optimal mixture experimental design
(D-Optimal MED) was employed to investigate the influence of different components on the response hardness of the
tablet. For tablet formulation, magnesium stearate, A (0.2-1.0% w/w), menthol, B (0.2-1.0% w/w), lemon powder, C
(1.0-10.0 w/w), maltodextrin, D (5.0 -10.0) and glucose, E (37.5-53.1%) are the variables while red pitaya powder
and preservative are fixed components. The experimental data were used to analyze analysis of variance (ANOVA)
and to develop a polynomial regression model for tablet hardness in terms of the five design factors considered
in this study. D-Optimal MED predicted the hardness of the tablet at 8.5 kg/cm2
. The results showed that the best
mixture was the formulation that included 0.66% A, 0.74% B, 6.15% C, 7.61% D and 44.34% E, with the actual
hardness of the optimized tablet recorded at 8.581 kg/cm2 (R2
= 0.9925). The study demonstrated the potentiality of
mixed fruit tablets as a nutritional supplement with therapeutic properties for general consumers well-being. |
| first_indexed | 2025-11-15T00:46:30Z |
| format | Article |
| id | oai:generic.eprints.org:20877 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:46:30Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:208772022-12-28T05:11:57Z http://journalarticle.ukm.my/20877/ Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design Ezzah Abd Manan, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Mohd Izuan Effendi Halmi, The powder of mixed fruits that are Lemon (Citrus limon) and Red Pitaya (Hylocereus polyrhizus) was used as a nutritional supplement in tablet form for nutraceutical application. D-optimal mixture experimental design (D-Optimal MED) was employed to investigate the influence of different components on the response hardness of the tablet. For tablet formulation, magnesium stearate, A (0.2-1.0% w/w), menthol, B (0.2-1.0% w/w), lemon powder, C (1.0-10.0 w/w), maltodextrin, D (5.0 -10.0) and glucose, E (37.5-53.1%) are the variables while red pitaya powder and preservative are fixed components. The experimental data were used to analyze analysis of variance (ANOVA) and to develop a polynomial regression model for tablet hardness in terms of the five design factors considered in this study. D-Optimal MED predicted the hardness of the tablet at 8.5 kg/cm2 . The results showed that the best mixture was the formulation that included 0.66% A, 0.74% B, 6.15% C, 7.61% D and 44.34% E, with the actual hardness of the optimized tablet recorded at 8.581 kg/cm2 (R2 = 0.9925). The study demonstrated the potentiality of mixed fruit tablets as a nutritional supplement with therapeutic properties for general consumers well-being. Penerbit Universiti Kebangsaan Malaysia 2022-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20877/1/19.pdf Ezzah Abd Manan, and Siti Salwa Abd Gani, and Uswatun Hasanah Zaidan, and Mohd Izuan Effendi Halmi, (2022) Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design. Sains Malaysiana, 51 (10). pp. 3347-3357. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil10_2022/KandunganJilid51Bil10_2022.html |
| spellingShingle | Ezzah Abd Manan, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Mohd Izuan Effendi Halmi, Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design |
| title | Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design |
| title_full | Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design |
| title_fullStr | Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design |
| title_full_unstemmed | Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design |
| title_short | Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design |
| title_sort | formulation and hardness evaluation of tablets containing citrus limon and hylocereus polyrhizus powder using d-optimal mixture design |
| url | http://journalarticle.ukm.my/20877/ http://journalarticle.ukm.my/20877/ http://journalarticle.ukm.my/20877/1/19.pdf |