Formulation and hardness evaluation of tablets containing Citrus limon and Hylocereus polyrhizus powder using D-Optimal mixture design
The powder of mixed fruits that are Lemon (Citrus limon) and Red Pitaya (Hylocereus polyrhizus) was used as a nutritional supplement in tablet form for nutraceutical application. D-optimal mixture experimental design (D-Optimal MED) was employed to investigate the influence of different componen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/20877/ http://journalarticle.ukm.my/20877/1/19.pdf |
| Summary: | The powder of mixed fruits that are Lemon (Citrus limon) and Red Pitaya (Hylocereus polyrhizus) was used as
a nutritional supplement in tablet form for nutraceutical application. D-optimal mixture experimental design
(D-Optimal MED) was employed to investigate the influence of different components on the response hardness of the
tablet. For tablet formulation, magnesium stearate, A (0.2-1.0% w/w), menthol, B (0.2-1.0% w/w), lemon powder, C
(1.0-10.0 w/w), maltodextrin, D (5.0 -10.0) and glucose, E (37.5-53.1%) are the variables while red pitaya powder
and preservative are fixed components. The experimental data were used to analyze analysis of variance (ANOVA)
and to develop a polynomial regression model for tablet hardness in terms of the five design factors considered
in this study. D-Optimal MED predicted the hardness of the tablet at 8.5 kg/cm2
. The results showed that the best
mixture was the formulation that included 0.66% A, 0.74% B, 6.15% C, 7.61% D and 44.34% E, with the actual
hardness of the optimized tablet recorded at 8.581 kg/cm2 (R2
= 0.9925). The study demonstrated the potentiality of
mixed fruit tablets as a nutritional supplement with therapeutic properties for general consumers well-being. |
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