Retrospective review of the adjunctive use of pre- operative ranibizumab “LUCENTISTM” in the surgical management of diabetic retinopathy in a Tertiary Referral Hospital in Malaysia
A retrospective case series review was conducted to determine the pre-operative role and safety of pre-operative adjunctive anti-vascular endothelial growth factor (anti-VEGF) agent ranibizumab “LUCENTISTM” in patients with diabetic retinopathy requiring vitrectomy. The study involved twenty conse...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit UKM
2010
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| Online Access: | http://journalarticle.ukm.my/2086/ http://journalarticle.ukm.my/2086/1/08MS090_4144.pdf |
| _version_ | 1848809754032340992 |
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| author | Bastion MLC, Siti Aishah S, Aida Zairani MZ, Barkeh HJ, |
| author_facet | Bastion MLC, Siti Aishah S, Aida Zairani MZ, Barkeh HJ, |
| author_sort | Bastion MLC, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | A retrospective case series review was conducted to determine the pre-operative role
and safety of pre-operative adjunctive anti-vascular endothelial growth factor (anti-VEGF) agent ranibizumab “LUCENTISTM” in patients with diabetic retinopathy requiring
vitrectomy. The study involved twenty consecutive eyes of sixteen patients (age range:
46-72 years; mean 57.5 years) which received intravitreal injection of 0.5 - 1 mg of
ranibizumab 3 to 8 days (mean 4.4 days) prior to vitrectomy for diabetic retinopathy.
There were no local or systemic post-injection complications. Indications for vitrectomy
were retinal detachment (RD) [n=11; 3 combined tractional (TRD) - rhegmatogenous RD
(RRD), 8 TRD], TRD with vitreous haemorrhage (VH) (n=3) ,VH (n=8) and vitreomacular
traction syndrome (n=1). Inclusion criteria include all consecutive eyes of
diabetic patients requiring vitrectomy receiving a first pre-operative injection of anti-
VEGF. Pre-operative visual acuity (VA) ranged from 6/36 to light perception. All eyes had
minimal to moderate intraoperative bleeding. Post-operative VH in eyes without
tamponade or gas tamponade was nil (n=1), mild (n=13) or moderate (n=1). Silicone
filled eyes had nil (n=1), moderate (n=3) or severe haemorrhages (n=1). Post-operative
VA was unchanged (n=2) (10%), improved (n = 14) (70%) or worsened (n=4). VA was
2/60 or better (n=15) to no light perception (n=1). Two eyes achieved 6/12 or better
vision (10%). Ten eyes (50%) had 6/36 or better vision. In conclusion, pre-operative
intravitreal ranibizumab is safe and useful in diabetic vitrectomy and appears to help with
perioperative bleeding leading to improvement in vision. |
| first_indexed | 2025-11-14T23:19:38Z |
| format | Article |
| id | oai:generic.eprints.org:2086 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:19:38Z |
| publishDate | 2010 |
| publisher | Penerbit UKM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:20862016-12-14T06:30:51Z http://journalarticle.ukm.my/2086/ Retrospective review of the adjunctive use of pre- operative ranibizumab “LUCENTISTM” in the surgical management of diabetic retinopathy in a Tertiary Referral Hospital in Malaysia Bastion MLC, Siti Aishah S, Aida Zairani MZ, Barkeh HJ, A retrospective case series review was conducted to determine the pre-operative role and safety of pre-operative adjunctive anti-vascular endothelial growth factor (anti-VEGF) agent ranibizumab “LUCENTISTM” in patients with diabetic retinopathy requiring vitrectomy. The study involved twenty consecutive eyes of sixteen patients (age range: 46-72 years; mean 57.5 years) which received intravitreal injection of 0.5 - 1 mg of ranibizumab 3 to 8 days (mean 4.4 days) prior to vitrectomy for diabetic retinopathy. There were no local or systemic post-injection complications. Indications for vitrectomy were retinal detachment (RD) [n=11; 3 combined tractional (TRD) - rhegmatogenous RD (RRD), 8 TRD], TRD with vitreous haemorrhage (VH) (n=3) ,VH (n=8) and vitreomacular traction syndrome (n=1). Inclusion criteria include all consecutive eyes of diabetic patients requiring vitrectomy receiving a first pre-operative injection of anti- VEGF. Pre-operative visual acuity (VA) ranged from 6/36 to light perception. All eyes had minimal to moderate intraoperative bleeding. Post-operative VH in eyes without tamponade or gas tamponade was nil (n=1), mild (n=13) or moderate (n=1). Silicone filled eyes had nil (n=1), moderate (n=3) or severe haemorrhages (n=1). Post-operative VA was unchanged (n=2) (10%), improved (n = 14) (70%) or worsened (n=4). VA was 2/60 or better (n=15) to no light perception (n=1). Two eyes achieved 6/12 or better vision (10%). Ten eyes (50%) had 6/36 or better vision. In conclusion, pre-operative intravitreal ranibizumab is safe and useful in diabetic vitrectomy and appears to help with perioperative bleeding leading to improvement in vision. Penerbit UKM 2010 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2086/1/08MS090_4144.pdf Bastion MLC, and Siti Aishah S, and Aida Zairani MZ, and Barkeh HJ, (2010) Retrospective review of the adjunctive use of pre- operative ranibizumab “LUCENTISTM” in the surgical management of diabetic retinopathy in a Tertiary Referral Hospital in Malaysia. Medicine & Health, 5 (2). pp. 93-102. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php |
| spellingShingle | Bastion MLC, Siti Aishah S, Aida Zairani MZ, Barkeh HJ, Retrospective review of the adjunctive use of pre- operative ranibizumab “LUCENTISTM” in the surgical management of diabetic retinopathy in a Tertiary Referral Hospital in Malaysia |
| title | Retrospective review of the adjunctive use of pre-
operative ranibizumab “LUCENTISTM” in the surgical
management of diabetic retinopathy in a Tertiary
Referral Hospital in Malaysia |
| title_full | Retrospective review of the adjunctive use of pre-
operative ranibizumab “LUCENTISTM” in the surgical
management of diabetic retinopathy in a Tertiary
Referral Hospital in Malaysia |
| title_fullStr | Retrospective review of the adjunctive use of pre-
operative ranibizumab “LUCENTISTM” in the surgical
management of diabetic retinopathy in a Tertiary
Referral Hospital in Malaysia |
| title_full_unstemmed | Retrospective review of the adjunctive use of pre-
operative ranibizumab “LUCENTISTM” in the surgical
management of diabetic retinopathy in a Tertiary
Referral Hospital in Malaysia |
| title_short | Retrospective review of the adjunctive use of pre-
operative ranibizumab “LUCENTISTM” in the surgical
management of diabetic retinopathy in a Tertiary
Referral Hospital in Malaysia |
| title_sort | retrospective review of the adjunctive use of pre-
operative ranibizumab “lucentistm” in the surgical
management of diabetic retinopathy in a tertiary
referral hospital in malaysia |
| url | http://journalarticle.ukm.my/2086/ http://journalarticle.ukm.my/2086/ http://journalarticle.ukm.my/2086/1/08MS090_4144.pdf |