Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit UKM
2010
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| Online Access: | http://journalarticle.ukm.my/2079/ http://journalarticle.ukm.my/2079/1/08MS090_4144.pdf |
| _version_ | 1848809752091426816 |
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| author | Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB, |
| author_facet | Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB, |
| author_sort | Phan CL, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia
(AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype.
Several studies showed that patients carrying this abnormality demonstrated good
response to standard chemotherapy but also have a high incidence of disease relapse.
Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4
of the FAB subtypes. We report a case of a 33-year-old female with an apparently
clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom
cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to
t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21)
with trisomy 4 in AML are unclear but patients bearing this abnormality are associated
with a poor prognosis. |
| first_indexed | 2025-11-14T23:19:36Z |
| format | Article |
| id | oai:generic.eprints.org:2079 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T23:19:36Z |
| publishDate | 2010 |
| publisher | Penerbit UKM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:20792016-12-14T06:30:50Z http://journalarticle.ukm.my/2079/ Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML) Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB, The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a high incidence of disease relapse. Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4 of the FAB subtypes. We report a case of a 33-year-old female with an apparently clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21) with trisomy 4 in AML are unclear but patients bearing this abnormality are associated with a poor prognosis. Penerbit UKM 2010 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2079/1/08MS090_4144.pdf Phan CL, and Ong TC, and Chang KM, and Zubaidah Z, and Puteri Jamilatul NMB, (2010) Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML). Medicine & Health, 5 (1). pp. 45-48. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php |
| spellingShingle | Phan CL, Ong TC, Chang KM, Zubaidah Z, Puteri Jamilatul NMB, Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML) |
| title | Concomitant t(8;21) and trisomy 4 in a patient with Acute
Myeloid Leukemia (AML) |
| title_full | Concomitant t(8;21) and trisomy 4 in a patient with Acute
Myeloid Leukemia (AML) |
| title_fullStr | Concomitant t(8;21) and trisomy 4 in a patient with Acute
Myeloid Leukemia (AML) |
| title_full_unstemmed | Concomitant t(8;21) and trisomy 4 in a patient with Acute
Myeloid Leukemia (AML) |
| title_short | Concomitant t(8;21) and trisomy 4 in a patient with Acute
Myeloid Leukemia (AML) |
| title_sort | concomitant t(8;21) and trisomy 4 in a patient with acute
myeloid leukemia (aml) |
| url | http://journalarticle.ukm.my/2079/ http://journalarticle.ukm.my/2079/ http://journalarticle.ukm.my/2079/1/08MS090_4144.pdf |