The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
Mature cystic teratoma is the commonest ovarian germ cell tumour which accounts for 70% of all benign ovarian neoplasms in the reproductive age groups. Being a pluripotent germ cell tumour, mature cystic teratoma has at least two out of three mature embryonic germ cell components: ectoderm, meso...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/20626/ http://journalarticle.ukm.my/20626/1/25_ms0245_pdf_19410.pdf |
| _version_ | 1848815152556670976 |
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| author | Wong, Yin Ping Tan, GC |
| author_facet | Wong, Yin Ping Tan, GC |
| author_sort | Wong, Yin Ping |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Mature cystic teratoma is the commonest ovarian germ cell tumour which accounts for 70% of all benign ovarian neoplasms in the reproductive age groups. Being a
pluripotent germ cell tumour, mature cystic teratoma has at least two out of three
mature embryonic germ cell components: ectoderm, mesoderm and endoderm.
The presence of multiple cystic spaces within the tumour wall, also known as
pneumatosis cystoides-like appearance is rarely described but a characteristic
feature in cystic teratoma of the ovary. Currently, there is little information
concerning the mechanism of its formation. Herein, we described an unusual case
of ovarian mature cystic teratoma in a 31-year-old pregnant female with multiple
sieve-like areas resembling pneumatosis cystoides of the intestine. Macroscopic
and histological examination of the ovary revealed features diagnostic of mature
cystic teratoma. Intriguingly, multiple cystic spaces of variable sizes were found
within the cyst wall histologically. They were lined partially or completely by foamy
histiocytes and foreign body type multinucleated giant cells, exhibiting strong
CD68 immunoreactivity. Vascular endothelial markers (CD31 and CD34) and
epithelial marker (cytokeratin AE1/AE3) were negative. A diagnosis of mature cystic
teratoma with pneumatosis cystoides-like feature was rendered. The patient was
discharged well with no signs and symptoms of early labour. The etiopathogenesis
of this intriguing histological feature is briefly discussed in this article. |
| first_indexed | 2025-11-15T00:45:26Z |
| format | Article |
| id | oai:generic.eprints.org:20626 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:45:26Z |
| publishDate | 2018 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:206262022-11-28T13:16:15Z http://journalarticle.ukm.my/20626/ The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary Wong, Yin Ping Tan, GC Mature cystic teratoma is the commonest ovarian germ cell tumour which accounts for 70% of all benign ovarian neoplasms in the reproductive age groups. Being a pluripotent germ cell tumour, mature cystic teratoma has at least two out of three mature embryonic germ cell components: ectoderm, mesoderm and endoderm. The presence of multiple cystic spaces within the tumour wall, also known as pneumatosis cystoides-like appearance is rarely described but a characteristic feature in cystic teratoma of the ovary. Currently, there is little information concerning the mechanism of its formation. Herein, we described an unusual case of ovarian mature cystic teratoma in a 31-year-old pregnant female with multiple sieve-like areas resembling pneumatosis cystoides of the intestine. Macroscopic and histological examination of the ovary revealed features diagnostic of mature cystic teratoma. Intriguingly, multiple cystic spaces of variable sizes were found within the cyst wall histologically. They were lined partially or completely by foamy histiocytes and foreign body type multinucleated giant cells, exhibiting strong CD68 immunoreactivity. Vascular endothelial markers (CD31 and CD34) and epithelial marker (cytokeratin AE1/AE3) were negative. A diagnosis of mature cystic teratoma with pneumatosis cystoides-like feature was rendered. The patient was discharged well with no signs and symptoms of early labour. The etiopathogenesis of this intriguing histological feature is briefly discussed in this article. Pusat Perubatan Universiti Kebangsaan Malaysia 2018-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20626/1/25_ms0245_pdf_19410.pdf Wong, Yin Ping and Tan, GC (2018) The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary. Medicine & Health, 13 (2). pp. 223-228. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/13/2 |
| spellingShingle | Wong, Yin Ping Tan, GC The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary |
| title | The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary |
| title_full | The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary |
| title_fullStr | The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary |
| title_full_unstemmed | The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary |
| title_short | The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary |
| title_sort | eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary |
| url | http://journalarticle.ukm.my/20626/ http://journalarticle.ukm.my/20626/ http://journalarticle.ukm.my/20626/1/25_ms0245_pdf_19410.pdf |