IRE1α promotes cell apoptosis and an inflammatory response in endoplasmic reticulum stress-induced rheumatoid arthritis fibroblast-like synovial cells by enhancing autophagy

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IRE1α promotes cell apoptosis and an inflammatory response in endoplasmic reticulum stress-induced rheumatoid arthritis fibroblast-like synovial cells by enhancing autophagy

Endoplasmic reticulum (ER) stress can induce autophagy via the unfolded protein response (UPR), and autophagy can regulate the activation of inflammasomes. Inositol-requiring enzyme 1α (IRE1α) is a transducer of the UPR in cells with ER stress. Here, we investigated the role of IRE1α and its imp...

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Bibliographic Details
Main Authors:	Yang, Jialiang, Ma, Zhenzhen, Jia, Qian, Li, Yanshan, Lu, Yucheng, Yang, Qingrui
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2022
Online Access:	http://journalarticle.ukm.my/20464/ http://journalarticle.ukm.my/20464/1/18.pdf

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