Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats
The current investigation was proposed to assess the effectiveness of the combination of resveratrol and ascorbic acid against Isoproterenol (ISO)-induced myocardial infarction in rats. The experimental model was divided into six groups (n = 6 in each group). Group I: control, Group 2: isoproterenol...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/20243/ http://journalarticle.ukm.my/20243/1/16.pdf |
| _version_ | 1848815052160761856 |
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| author | Gao, Haichao Wang, Hong Han, Tingting Huang, Xiansheng Li, Shucheng Wang, Xibing |
| author_facet | Gao, Haichao Wang, Hong Han, Tingting Huang, Xiansheng Li, Shucheng Wang, Xibing |
| author_sort | Gao, Haichao |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The current investigation was proposed to assess the effectiveness of the combination of resveratrol and ascorbic acid against Isoproterenol (ISO)-induced myocardial infarction in rats. The experimental model was divided into six groups (n = 6 in each group). Group I: control, Group 2: isoproterenol (ISO)-100 mg/kg b.wt, Group 3: ISO+Resveratrol (RES) (20 mg/kg b.wt) treated, Group 4: ISO+ Ascorbic acid (AA) (80 mg/kg b.wt) treated, Group 5: ISO+RES (20 mg/kg b.wt)+AA (80 mg/kg b.wt) treated and Group 6: RES (20 mg/kg b.wt)+ AA (80 mg/kg b.wt) alone treated. The study showed an increase in lipid peroxides and cardiac markers in the serum samples of experimental animals administered with ISO. Treatment with RES and AA individually and a combinational formulation brought a significant decrease in lipid peroxides and cardiac markers. They increased the level of enzymatic antioxidants and non-enzymatic antioxidant levels. Histopathological results showed the distortion of heart architecture among the experimental groups administered with ISO and significant recovery when treated with RES and AA individually and in their combination. The study presents the effective combination of RES and AA in combating ISO-induced myocardial infarction and protection against ROS-mediated oxidative stress. |
| first_indexed | 2025-11-15T00:43:50Z |
| format | Article |
| id | oai:generic.eprints.org:20243 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:43:50Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
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| spelling | oai:generic.eprints.org:202432022-10-25T07:40:54Z http://journalarticle.ukm.my/20243/ Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats Gao, Haichao Wang, Hong Han, Tingting Huang, Xiansheng Li, Shucheng Wang, Xibing The current investigation was proposed to assess the effectiveness of the combination of resveratrol and ascorbic acid against Isoproterenol (ISO)-induced myocardial infarction in rats. The experimental model was divided into six groups (n = 6 in each group). Group I: control, Group 2: isoproterenol (ISO)-100 mg/kg b.wt, Group 3: ISO+Resveratrol (RES) (20 mg/kg b.wt) treated, Group 4: ISO+ Ascorbic acid (AA) (80 mg/kg b.wt) treated, Group 5: ISO+RES (20 mg/kg b.wt)+AA (80 mg/kg b.wt) treated and Group 6: RES (20 mg/kg b.wt)+ AA (80 mg/kg b.wt) alone treated. The study showed an increase in lipid peroxides and cardiac markers in the serum samples of experimental animals administered with ISO. Treatment with RES and AA individually and a combinational formulation brought a significant decrease in lipid peroxides and cardiac markers. They increased the level of enzymatic antioxidants and non-enzymatic antioxidant levels. Histopathological results showed the distortion of heart architecture among the experimental groups administered with ISO and significant recovery when treated with RES and AA individually and in their combination. The study presents the effective combination of RES and AA in combating ISO-induced myocardial infarction and protection against ROS-mediated oxidative stress. Penerbit Universiti Kebangsaan Malaysia 2022-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20243/1/16.pdf Gao, Haichao and Wang, Hong and Han, Tingting and Huang, Xiansheng and Li, Shucheng and Wang, Xibing (2022) Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats. Sains Malaysiana, 51 (7). pp. 2137-2146. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil7_2022/KandunganJilid51Bil7_2022.html |
| spellingShingle | Gao, Haichao Wang, Hong Han, Tingting Huang, Xiansheng Li, Shucheng Wang, Xibing Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats |
| title | Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats |
| title_full | Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats |
| title_fullStr | Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats |
| title_full_unstemmed | Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats |
| title_short | Combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats |
| title_sort | combined antioxidant formulation of ascorbic acid with resveratrol ameliorates isoproterenol-induced myocardial infarction in rats |
| url | http://journalarticle.ukm.my/20243/ http://journalarticle.ukm.my/20243/ http://journalarticle.ukm.my/20243/1/16.pdf |