Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice
Malaria-induced hypoglycemia is recognized as a serious complication of malaria and has one of the strongest associations with mortality in children. It has been speculated that oxidative stress and pro-inflammatory response during parasite infection were involved in its pathophysiology. Hence, this...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/20242/ http://journalarticle.ukm.my/20242/1/15.pdf |
| _version_ | 1848815051855626240 |
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| author | Rujikorn Rattanatham, Voravuth Somsak, |
| author_facet | Rujikorn Rattanatham, Voravuth Somsak, |
| author_sort | Rujikorn Rattanatham, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Malaria-induced hypoglycemia is recognized as a serious complication of malaria and has one of the strongest associations with mortality in children. It has been speculated that oxidative stress and pro-inflammatory response during parasite infection were involved in its pathophysiology. Hence, this study aimed to investigate the development of malaria-induced hypoglycemia during Plasmodium berghei ANKA (PbANKA) infection with particular attention to the involvement of c-peptide, interleukin-1β (IL-1β), and interferon-γ (IFN-γ). ICR mice were infected with 1×107 parasitized erythrocytes of PbANKA, and parasitemia was monitored, and the development of hypoglycemia was assessed by measuring plasma glucose levels. The change of c-peptide level was evaluated. The pro-inflammatory response of IL-1β and IFN-γ were also quantified in plasma. It was found that PbANKA infection resulted in hypoglycemia as indicated by a significantly (P < 0.05) decrease in plasma glucose levels on day 4 post-infection and associated with parasitemia. The c-peptide was slightly increased at day 2 post-infection, and then significantly (P < 0.05) decreased since day 4. Furthermore, we observed a significantly (P < 0.05) increased IL-1β, firstly responded, at day 2 post-infection followed by increasing the IFN-γ level at day 4 in PbANKA-induced hypoglycemia. Our findings support the idea that hypoinsulinemic hypoglycemia in the PbANKA infected mice may be involved in the high IL-1β and IFN-γ against the parasite infection. |
| first_indexed | 2025-11-15T00:43:50Z |
| format | Article |
| id | oai:generic.eprints.org:20242 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:43:50Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:202422022-10-25T07:39:26Z http://journalarticle.ukm.my/20242/ Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice Rujikorn Rattanatham, Voravuth Somsak, Malaria-induced hypoglycemia is recognized as a serious complication of malaria and has one of the strongest associations with mortality in children. It has been speculated that oxidative stress and pro-inflammatory response during parasite infection were involved in its pathophysiology. Hence, this study aimed to investigate the development of malaria-induced hypoglycemia during Plasmodium berghei ANKA (PbANKA) infection with particular attention to the involvement of c-peptide, interleukin-1β (IL-1β), and interferon-γ (IFN-γ). ICR mice were infected with 1×107 parasitized erythrocytes of PbANKA, and parasitemia was monitored, and the development of hypoglycemia was assessed by measuring plasma glucose levels. The change of c-peptide level was evaluated. The pro-inflammatory response of IL-1β and IFN-γ were also quantified in plasma. It was found that PbANKA infection resulted in hypoglycemia as indicated by a significantly (P < 0.05) decrease in plasma glucose levels on day 4 post-infection and associated with parasitemia. The c-peptide was slightly increased at day 2 post-infection, and then significantly (P < 0.05) decreased since day 4. Furthermore, we observed a significantly (P < 0.05) increased IL-1β, firstly responded, at day 2 post-infection followed by increasing the IFN-γ level at day 4 in PbANKA-induced hypoglycemia. Our findings support the idea that hypoinsulinemic hypoglycemia in the PbANKA infected mice may be involved in the high IL-1β and IFN-γ against the parasite infection. Penerbit Universiti Kebangsaan Malaysia 2022-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20242/1/15.pdf Rujikorn Rattanatham, and Voravuth Somsak, (2022) Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice. Sains Malaysiana, 51 (7). pp. 2129-2136. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil7_2022/KandunganJilid51Bil7_2022.html |
| spellingShingle | Rujikorn Rattanatham, Voravuth Somsak, Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice |
| title | Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice |
| title_full | Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice |
| title_fullStr | Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice |
| title_full_unstemmed | Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice |
| title_short | Interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in Plasmodium berghei ANKA-infected mice |
| title_sort | interleukin-1β and interferon-γ are associated with malaria-induced hypoinsulinemic hypoglycemia in plasmodium berghei anka-infected mice |
| url | http://journalarticle.ukm.my/20242/ http://journalarticle.ukm.my/20242/ http://journalarticle.ukm.my/20242/1/15.pdf |