Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ
Early detection of feline hepatic lipidosis (FHL) with appropriate treatment can increase prognosis significantly. This study looks into the serum biochemistry and lipid composition of serum and liver samples in a group of stray cats (N=18) collected from pounds in Klang Valley, Malaysia. Alanine am...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/20228/ http://journalarticle.ukm.my/20228/1/1.pdf |
| _version_ | 1848815047947583488 |
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| author | F. Salleh, Goh, Y.M. Lau, S.F. P.A.M.A. Rani, R. Radzi, M. Mazlan, A.R. Alashraf, Goh, S.H. S.A. Rahman, T.B.M. Mohidin, M.N. Akmal, A.N. Ilias, M. Ajat, |
| author_facet | F. Salleh, Goh, Y.M. Lau, S.F. P.A.M.A. Rani, R. Radzi, M. Mazlan, A.R. Alashraf, Goh, S.H. S.A. Rahman, T.B.M. Mohidin, M.N. Akmal, A.N. Ilias, M. Ajat, |
| author_sort | F. Salleh, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Early detection of feline hepatic lipidosis (FHL) with appropriate treatment can increase prognosis significantly. This study looks into the serum biochemistry and lipid composition of serum and liver samples in a group of stray cats (N=18) collected from pounds in Klang Valley, Malaysia. Alanine aminotransferase (ALT) in blood serum was used to detect for liver damage possibly due to FHL, confirmed through light microscopy, serum biochemistry (triglyceride, cholesterol, creatinine, and urea), liver triglyceride and cholesterol concentrations, and liver RNA expression of lipid droplet regulators peroxisome proliferator-activated receptors (PPARs). Differing severity of FHL in samples were divided and grouped using an adapted scoring method observing fatty change of liver (FCL) with trends between FCL groups investigated. Elevated serum ALT reflective of increasing FCL severity was observed with elevated concentrations of liver TAG and cholesterol levels. Serum TAG and cholesterol decreased with heightened FCL pointing to fatty acid oxidation and lipid restoration in the liver, supported by PPAR-γ expression which also propose macrophage activation for liver recovery alongside PPAR-δ for lipogenesis and inflammatory reactions. Elevated serum creatinine and urea levels with increasing FCL severity propose overall intact hepatic function in the stray cat samples. |
| first_indexed | 2025-11-15T00:43:46Z |
| format | Article |
| id | oai:generic.eprints.org:20228 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:43:46Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:202282022-10-25T07:19:39Z http://journalarticle.ukm.my/20228/ Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ F. Salleh, Goh, Y.M. Lau, S.F. P.A.M.A. Rani, R. Radzi, M. Mazlan, A.R. Alashraf, Goh, S.H. S.A. Rahman, T.B.M. Mohidin, M.N. Akmal, A.N. Ilias, M. Ajat, Early detection of feline hepatic lipidosis (FHL) with appropriate treatment can increase prognosis significantly. This study looks into the serum biochemistry and lipid composition of serum and liver samples in a group of stray cats (N=18) collected from pounds in Klang Valley, Malaysia. Alanine aminotransferase (ALT) in blood serum was used to detect for liver damage possibly due to FHL, confirmed through light microscopy, serum biochemistry (triglyceride, cholesterol, creatinine, and urea), liver triglyceride and cholesterol concentrations, and liver RNA expression of lipid droplet regulators peroxisome proliferator-activated receptors (PPARs). Differing severity of FHL in samples were divided and grouped using an adapted scoring method observing fatty change of liver (FCL) with trends between FCL groups investigated. Elevated serum ALT reflective of increasing FCL severity was observed with elevated concentrations of liver TAG and cholesterol levels. Serum TAG and cholesterol decreased with heightened FCL pointing to fatty acid oxidation and lipid restoration in the liver, supported by PPAR-γ expression which also propose macrophage activation for liver recovery alongside PPAR-δ for lipogenesis and inflammatory reactions. Elevated serum creatinine and urea levels with increasing FCL severity propose overall intact hepatic function in the stray cat samples. Penerbit Universiti Kebangsaan Malaysia 2022-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20228/1/1.pdf F. Salleh, and Goh, Y.M. and Lau, S.F. and P.A.M.A. Rani, and R. Radzi, and M. Mazlan, and A.R. Alashraf, and Goh, S.H. and S.A. Rahman, and T.B.M. Mohidin, and M.N. Akmal, and A.N. Ilias, and M. Ajat, (2022) Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ. Sains Malaysiana, 51 (7). pp. 1957-1968. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil7_2022/KandunganJilid51Bil7_2022.html |
| spellingShingle | F. Salleh, Goh, Y.M. Lau, S.F. P.A.M.A. Rani, R. Radzi, M. Mazlan, A.R. Alashraf, Goh, S.H. S.A. Rahman, T.B.M. Mohidin, M.N. Akmal, A.N. Ilias, M. Ajat, Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ |
| title | Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ |
| title_full | Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ |
| title_fullStr | Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ |
| title_full_unstemmed | Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ |
| title_short | Elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver RNA expression of PPAR-δ and PPAR-γ |
| title_sort | elucidating hepatic lipidosis in stray cats through serum biochemistry, liver histopathology and liver rna expression of ppar-δ and ppar-γ |
| url | http://journalarticle.ukm.my/20228/ http://journalarticle.ukm.my/20228/ http://journalarticle.ukm.my/20228/1/1.pdf |