Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension
Pregnancy induced hypertension (PIH) is commonly encountered in hypertensive disease in pregnancy (HDP) and important cause of feto-maternal morbidity and mortality. Abnormal changes of placenta development in PIH leads to abnormal elevation of second trimester maternal hCG level. Thus, it may ha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Pusat Perubatan Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/20207/ http://journalarticle.ukm.my/20207/1/14_ms0212_pdf_34008.pdf |
| _version_ | 1848815042321973248 |
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| author | Munirah Md Mansor, Khalidah MB, Dian Nasriana N, Hanita O, Nor Azlin MI, |
| author_facet | Munirah Md Mansor, Khalidah MB, Dian Nasriana N, Hanita O, Nor Azlin MI, |
| author_sort | Munirah Md Mansor, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Pregnancy induced hypertension (PIH) is commonly encountered in hypertensive
disease in pregnancy (HDP) and important cause of feto-maternal morbidity and
mortality. Abnormal changes of placenta development in PIH leads to abnormal
elevation of second trimester maternal hCG level. Thus, it may have a role in
prediction of PIH. The objective of this study was to evaluate the ability of serum
hCG levels during early second trimester to predict PIH and obstetric outcome at
later gestation. We conducted a cohort study which comprised 34 pregnant women
varying from 14–20 weeks of gestation with serum hCG level taken at points of
recruitment. Serum hCG was measured by a chemiluminescent immunoassay.
Three (8.8%) pregnant women developed late onset PIH while the remainder were
normotensive. The diagnostic performance of second trimester hCG in predicting
PIH as assessed by receiver operator characteristic curve was poor (AUC = 0.398).
Multiple of median (MoM) were used to improve the hCG performance and MoM
of >2 MoM were considered as elevated hCG level. All pregnancies with PIH had
<2 MoM. In normotensive pregnancy, 29 (93.5%) women had hCG <2 MoM and
2 (6.5%) women had hCG >2 MoM (p>0.655). There was no significant association
of hCG level and pregnancy outcome. In conclusion, estimation of second trimester
hCG is a poor predictive marker for PIH. These findings are limited by the less
number of hypertensive cases. |
| first_indexed | 2025-11-15T00:43:41Z |
| format | Article |
| id | oai:generic.eprints.org:20207 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:43:41Z |
| publishDate | 2018 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:202072022-10-21T08:29:21Z http://journalarticle.ukm.my/20207/ Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension Munirah Md Mansor, Khalidah MB, Dian Nasriana N, Hanita O, Nor Azlin MI, Pregnancy induced hypertension (PIH) is commonly encountered in hypertensive disease in pregnancy (HDP) and important cause of feto-maternal morbidity and mortality. Abnormal changes of placenta development in PIH leads to abnormal elevation of second trimester maternal hCG level. Thus, it may have a role in prediction of PIH. The objective of this study was to evaluate the ability of serum hCG levels during early second trimester to predict PIH and obstetric outcome at later gestation. We conducted a cohort study which comprised 34 pregnant women varying from 14–20 weeks of gestation with serum hCG level taken at points of recruitment. Serum hCG was measured by a chemiluminescent immunoassay. Three (8.8%) pregnant women developed late onset PIH while the remainder were normotensive. The diagnostic performance of second trimester hCG in predicting PIH as assessed by receiver operator characteristic curve was poor (AUC = 0.398). Multiple of median (MoM) were used to improve the hCG performance and MoM of >2 MoM were considered as elevated hCG level. All pregnancies with PIH had <2 MoM. In normotensive pregnancy, 29 (93.5%) women had hCG <2 MoM and 2 (6.5%) women had hCG >2 MoM (p>0.655). There was no significant association of hCG level and pregnancy outcome. In conclusion, estimation of second trimester hCG is a poor predictive marker for PIH. These findings are limited by the less number of hypertensive cases. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20207/1/14_ms0212_pdf_34008.pdf Munirah Md Mansor, and Khalidah MB, and Dian Nasriana N, and Hanita O, and Nor Azlin MI, (2018) Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension. Medicine & Health, 13 (1). pp. 143-152. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/13/1 |
| spellingShingle | Munirah Md Mansor, Khalidah MB, Dian Nasriana N, Hanita O, Nor Azlin MI, Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension |
| title | Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension |
| title_full | Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension |
| title_fullStr | Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension |
| title_full_unstemmed | Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension |
| title_short | Early second trimester hCG of maternal serum as predictor marker for pregnancy induced hypertension |
| title_sort | early second trimester hcg of maternal serum as predictor marker for pregnancy induced hypertension |
| url | http://journalarticle.ukm.my/20207/ http://journalarticle.ukm.my/20207/ http://journalarticle.ukm.my/20207/1/14_ms0212_pdf_34008.pdf |