(+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors
The phytochemical study on the dichloromethane extract of Neolamarckia cadamba (Roxb.) Bosser has afforded two indole alkaloids, (+)-neocadambine A (1) and (-)-nauclederine (2). Their structures were confirmed by extensive spectroscopic analysis and by comparing with the reported data. (+)-Neocadamb...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/19747/ http://journalarticle.ukm.my/19747/1/10.pdf |
| _version_ | 1848814920933572608 |
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| author | Noor Aimi Othman, Liew, Sook Yee Blanchard, Patricia Derbré, Séverine Chong, Soon-Lim Abdul Manaf Ali, Khalijah Awang, |
| author_facet | Noor Aimi Othman, Liew, Sook Yee Blanchard, Patricia Derbré, Séverine Chong, Soon-Lim Abdul Manaf Ali, Khalijah Awang, |
| author_sort | Noor Aimi Othman, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The phytochemical study on the dichloromethane extract of Neolamarckia cadamba (Roxb.) Bosser has afforded two indole alkaloids, (+)-neocadambine A (1) and (-)-nauclederine (2). Their structures were confirmed by extensive spectroscopic analysis and by comparing with the reported data. (+)-Neocadambine A (1) and (-)-nauclederine (2) exhibited potent inhibition activity of advanced glycation end products (AGEs) with IC50 values of 1.2 and 0.95 mM, respectively, while the latter was almost two times more potent than the standard, aminoguanidine (1.8 mM). This is the first report on the compounds isolated from this plant with AGEs inhibition activity. In addition, (-)-nauclederine (2) was isolated for the first time in the genus of Neolamarckia. Complete 1H-NMR and 13C-NMR of compound 2 were also reported. |
| first_indexed | 2025-11-15T00:41:45Z |
| format | Article |
| id | oai:generic.eprints.org:19747 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:41:45Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:197472022-09-19T06:48:16Z http://journalarticle.ukm.my/19747/ (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors Noor Aimi Othman, Liew, Sook Yee Blanchard, Patricia Derbré, Séverine Chong, Soon-Lim Abdul Manaf Ali, Khalijah Awang, The phytochemical study on the dichloromethane extract of Neolamarckia cadamba (Roxb.) Bosser has afforded two indole alkaloids, (+)-neocadambine A (1) and (-)-nauclederine (2). Their structures were confirmed by extensive spectroscopic analysis and by comparing with the reported data. (+)-Neocadambine A (1) and (-)-nauclederine (2) exhibited potent inhibition activity of advanced glycation end products (AGEs) with IC50 values of 1.2 and 0.95 mM, respectively, while the latter was almost two times more potent than the standard, aminoguanidine (1.8 mM). This is the first report on the compounds isolated from this plant with AGEs inhibition activity. In addition, (-)-nauclederine (2) was isolated for the first time in the genus of Neolamarckia. Complete 1H-NMR and 13C-NMR of compound 2 were also reported. Penerbit Universiti Kebangsaan Malaysia 2022-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/19747/1/10.pdf Noor Aimi Othman, and Liew, Sook Yee and Blanchard, Patricia and Derbré, Séverine and Chong, Soon-Lim and Abdul Manaf Ali, and Khalijah Awang, (2022) (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors. Sains Malaysiana, 51 (6). pp. 1725-1732. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil6_2022/KandunganJilid51Bil6_2022.html |
| spellingShingle | Noor Aimi Othman, Liew, Sook Yee Blanchard, Patricia Derbré, Séverine Chong, Soon-Lim Abdul Manaf Ali, Khalijah Awang, (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors |
| title | (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors |
| title_full | (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors |
| title_fullStr | (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors |
| title_full_unstemmed | (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors |
| title_short | (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors |
| title_sort | (+)-neocadambine a and (-)-nauclederine isolated from the bark of neolamarckia cadamba (rubiaceae) as natural advanced glycation end products (ages) inhibitors |
| url | http://journalarticle.ukm.my/19747/ http://journalarticle.ukm.my/19747/ http://journalarticle.ukm.my/19747/1/10.pdf |