Tualang honey promotes apoptosis of the A549 lung adenocarcinoma cell line via modulation of PI3K/AKT signaling pathway-related proteins
The phosphatidylinositol 3-kinases (PI3Ks)/protein kinase B (AKT) signaling pathway is frequently overexpressed in lung adenocarcinoma and associated with carcinogenesis through cell proliferation, and apoptosis deactivation; and it also enhances chemotherapeutic drugs resistance. Tualang honey (...
| Main Authors: | Nazirah A, Puteri Shafinaz Abdul-Rahman |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2022
|
| Online Access: | http://journalarticle.ukm.my/19672/ http://journalarticle.ukm.my/19672/1/16_ms0561_pdf_50460.pdf |
Similar Items
Piper sarmentosum induced apoptosis via mitochondrial pathway in human lung adenocarcinoma cells, A549
by: Sirajudeen, Azila, et al.
Published: (2016)
by: Sirajudeen, Azila, et al.
Published: (2016)
Piper sarmentosum (Daun kaduk) induced apoptosis via mitochondrial pathway in human lung adenocarcinoma cells, A549
by: Sirajudeen, Azila, et al.
Published: (2016)
by: Sirajudeen, Azila, et al.
Published: (2016)
Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?
by: Singh, S., et al.
Published: (2015)
by: Singh, S., et al.
Published: (2015)
In-vitro cytotoxicity of Trigona itama honey against human lung adenocarcinoma epithelial cell line (A549)
by: Mohd Salim, Siti Norfitrah, et al.
Published: (2019)
by: Mohd Salim, Siti Norfitrah, et al.
Published: (2019)
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
by: Kannaiyan, R., et al.
Published: (2011)
by: Kannaiyan, R., et al.
Published: (2011)
The effects of Ficus auriculata (fig) on cell cycle profile and apoptosis activity of Human lung adenocarcinoma cells, A549
by: Jamil, Elyna Fatini, et al.
Published: (2016)
by: Jamil, Elyna Fatini, et al.
Published: (2016)
Ficus auriculata (fig) extracts induced cell cycle profile changes and apoptosis through caspase-independent pathway in human LungAdenocarcinoma cell line, A549
by: Jamil, Elyna Fatini, et al.
Published: (2017)
by: Jamil, Elyna Fatini, et al.
Published: (2017)
Vitamin D and Stimulates the PI3K-AKT signaling pathway in insulin resistant SK-N-SH neuronal cells
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy
by: Kaboli, Parham Jabbarzadeh, et al.
Published: (2021)
by: Kaboli, Parham Jabbarzadeh, et al.
Published: (2021)
Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway
by: Castresana, Javier S., et al.
Published: (2017)
by: Castresana, Javier S., et al.
Published: (2017)
Effects of albumin–chlorogenic acid nanoparticles on apoptosis and PI3K/Akt/mTOR pathway inhibitory activity in MDA-MB-435s cells
by: Alzahrani, Badr, et al.
Published: (2023)
by: Alzahrani, Badr, et al.
Published: (2023)
Vitamins D and E stimulate the PI3K-AKT signalling pathway in insulin-resistant SK-N-SH neuronal cells
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
by: Zaulkffali, Amirah Salwani, et al.
Published: (2019)
Protocatechuic acid induces apoptosis in human osteosarcoma cells by regulating P13K/AKT/ROS pathway
by: Mei, Qiyuan, et al.
Published: (2022)
by: Mei, Qiyuan, et al.
Published: (2022)
Antiproliferative activity of selected prophetic medicinal plants on human lung adenocarcinoma cells, A549
by: Abdul Ghani, Radiah, et al.
Published: (2015)
by: Abdul Ghani, Radiah, et al.
Published: (2015)
Sodium alginate encapsulated iron oxide decorated with thymoquinone nanocomposite induces apoptosis in human breast cancer cells via PI3K-Akt-mTOR pathway
by: Alzahrani, Badr, et al.
Published: (2023)
by: Alzahrani, Badr, et al.
Published: (2023)
Pomegranate juice induced cell cycle arrest and apoptosis through mitochondria pathway in human lung adenocarcinoma cells
by: Abdul Ghani, Radiah, et al.
Published: (2018)
by: Abdul Ghani, Radiah, et al.
Published: (2018)
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
by: Geyer, Felipe C., et al.
Published: (2018)
by: Geyer, Felipe C., et al.
Published: (2018)
An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation
by: Smit, L., et al.
Published: (2015)
by: Smit, L., et al.
Published: (2015)
A Potential Effect of Cordycepin on the Feedback between Polyadenylation and PI3K/Akt/mTOR Signalling
by: Lawrence, Steven
Published: (2023)
by: Lawrence, Steven
Published: (2023)
Ornithine decarboxylase gene expression in human lung adenocarcinoma cell (A549) treated with pomegranate juice
by: Abdul Ghani, Radiah, et al.
Published: (2015)
by: Abdul Ghani, Radiah, et al.
Published: (2015)
Discovery of novel antitumor nitric oxide-donating b-elemene hybrids through inhibiting the PI3K/Akt pathway
by: Chen, Jichao, et al.
Published: (2017)
by: Chen, Jichao, et al.
Published: (2017)
Nanocomposites of iron oxide, sodium alginate, and eugenol induce apoptosis via PI3K/Akt/mTOR signaling in Hep3 cells and in vivo hepatotoxicity in the zebrafish model
by: Elderdery, Abozer Y., et al.
Published: (2024)
by: Elderdery, Abozer Y., et al.
Published: (2024)
Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma
by: Huang, B., et al.
Published: (2016)
by: Huang, B., et al.
Published: (2016)
PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells
by: Chen, J., et al.
Published: (2015)
by: Chen, J., et al.
Published: (2015)
A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate
by: Falasca, Marco, et al.
Published: (2010)
by: Falasca, Marco, et al.
Published: (2010)
Comparison of the expression of PI3K/AKT pathway components in type 2 diabetic and non- diabetic human volunteers ex vivo
by: Khorami, Somayeh Alsadat Hosseini
Published: (2018)
by: Khorami, Somayeh Alsadat Hosseini
Published: (2018)
The role of polyamines in growth inhibition induced by Momordica charantia and Gynura procumbens in human lung adenocarcinoma cells, A549
by: AhmadSujangi, Nurhikmah, et al.
Published: (2016)
by: AhmadSujangi, Nurhikmah, et al.
Published: (2016)
Using the Cre/loxP recombination system to study the role of the PI3K/AKT signalling transduction pathway and the embryonic cellular origin of adult haematopoietic stem cells in the zebrafish
by: Jalali, Maryam
Published: (2013)
by: Jalali, Maryam
Published: (2013)
Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure
by: Suk, Peng Tang, et al.
Published: (2017)
by: Suk, Peng Tang, et al.
Published: (2017)
Regulation of phosphatidylinositol 3-kinase (PI3K/Akt) pathway in chicken and duck cells and its implications for influenza A virus pathogenesis
by: Kumar, Sanjeeva
Published: (2018)
by: Kumar, Sanjeeva
Published: (2018)
A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer
by: Kelvin Wong, Khai Voon, et al.
Published: (2022)
by: Kelvin Wong, Khai Voon, et al.
Published: (2022)
The role of polyamines as a chemopreventive agent in selected prophetic fruits against human lung adenocarcinoma cell line, A549
by: Abdul Ghani, Radiah, et al.
Published: (2018)
by: Abdul Ghani, Radiah, et al.
Published: (2018)
Identification of bcl-xl induced micrornas involved in the apoptotic properties of human lung adenocarcinoma cells, a549 / Norahayu Othman
by: Othman, Norahayu
Published: (2012)
by: Othman, Norahayu
Published: (2012)
The study of the Tualang honey viscosity
by: Abd. Rahim, Nour El Huda, et al.
Published: (2012)
by: Abd. Rahim, Nour El Huda, et al.
Published: (2012)
Rheology of Malaysian Tualang honey
by: Abd. Rahim, Nour El Huda, et al.
Published: (2011)
by: Abd. Rahim, Nour El Huda, et al.
Published: (2011)
Putative apoptosis effect of Momordica charantia Linn. extracts in human lung cancer cell line A549
by: K Thiagarajan, Siroshini
Published: (2019)
by: K Thiagarajan, Siroshini
Published: (2019)
PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
by: Braccini, L., et al.
Published: (2015)
by: Braccini, L., et al.
Published: (2015)
Induction of apoptosis via JNK and AKT/mTOR signaling pathways by Alternanthera sessilis (L.) R.Br. ex DC. in colorectal cancer in vitro and in vivo
by: Sivapragasam, Gothai
Published: (2019)
by: Sivapragasam, Gothai
Published: (2019)
Categorization of Gelam, Acacia and Tualang Honey odor-profile using k-nearest neighbors
by: Nurdiyana, Zahed, et al.
Published: (2018)
by: Nurdiyana, Zahed, et al.
Published: (2018)
Enhanced apoptotic activity of Pluronic F127 polymer-encapsulated chlorogenic acid nanoparticles through the PI3K/Akt/mTOR signaling pathway in liver cancer cells and in vivo toxicity studies in zebrafish
by: Alanazi, Fehaid, et al.
Published: (2023)
by: Alanazi, Fehaid, et al.
Published: (2023)
Similar Items
-
Piper sarmentosum induced apoptosis via mitochondrial pathway in human lung adenocarcinoma cells, A549
by: Sirajudeen, Azila, et al.
Published: (2016) -
Piper sarmentosum (Daun kaduk) induced apoptosis via mitochondrial pathway in human lung adenocarcinoma cells, A549
by: Sirajudeen, Azila, et al.
Published: (2016) -
Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?
by: Singh, S., et al.
Published: (2015) -
In-vitro cytotoxicity of Trigona itama honey against human lung adenocarcinoma epithelial cell line (A549)
by: Mohd Salim, Siti Norfitrah, et al.
Published: (2019) -
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
by: Kannaiyan, R., et al.
Published: (2011)