Correlation of metabolic syndrome with clinicopathological characteristics and treatment outcome in bladder cancer : a retrospective observational study
The relationship between metabolic syndrome (MetS) with the clinicopathological characteristics, chemotherapy responsiveness and survival outcome in bladder cancer is under-investigated and often conflicting. We retrospectively analysed data of 45 patients who were diagnosed with non-muscle invas...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/19669/ http://journalarticle.ukm.my/19669/1/13_ms0543_pdf_98879.pdf |
| Summary: | The relationship between metabolic syndrome (MetS) with the clinicopathological
characteristics, chemotherapy responsiveness and survival outcome in bladder
cancer is under-investigated and often conflicting. We retrospectively analysed
data of 45 patients who were diagnosed with non-muscle invasive bladder cancer
(NMIBC) or muscle-invasive bladder cancer (MIBC) and received chemotherapy
at the University of Malaya Medical Centre (UMMC) between 2010 and 2020.
Overall, 24 patients (53.3%) were presented with MetS criteria at the time of
diagnosis. Across MetS and its components, no significant association was found
with tumour pathological stage, histological grade, and chemotherapy response
in our patient population. Interestingly, there was a significant difference in overall
survival between patients with and without diabetes (62.47 + 8.32 months and
84.93 + 3.96 months respectively, p=0.045). Although no significant association
between MetS with bladder cancer clinicopathological characteristics and
treatment outcome was found, intensive care and lifestyle modification should be
considered for bladder cancer patients with metabolic disorders. |
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