Antioxidant capabilities of Litsea garciae bark extracts and their relation to the phytochemical compositions
The plant species belonging to the Litsea genus are widely investigated due to their nutritional and medicinal purposes. In this regard, this study is another similar sincere effort in which the antioxidant property and phytochemical composition of Litsea garciae (L. garciae) bark’s hexane, chloro...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/19515/ http://journalarticle.ukm.my/19515/1/10%2B-%2BANTIOXIDANT%2BCAPABILITIES%2BOF%2BLitsea%2Bgarciae%2BBARK%2BEXTRACTS%2B%281%29.pdf |
| _version_ | 1848814862298251264 |
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| author | Siti Zaleha Raduan, Qamar Uddin Ahmed, Abdul Razak Kasmuri, Muhamad Rusdi Ahmad Rusmili, Md Abdur Rashid Mia, Wan Mohd Azizi Wan Sulaiman, Muhammad Hamdi Mahmood, Mohd Farooq Shaikh, |
| author_facet | Siti Zaleha Raduan, Qamar Uddin Ahmed, Abdul Razak Kasmuri, Muhamad Rusdi Ahmad Rusmili, Md Abdur Rashid Mia, Wan Mohd Azizi Wan Sulaiman, Muhammad Hamdi Mahmood, Mohd Farooq Shaikh, |
| author_sort | Siti Zaleha Raduan, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The plant species belonging to the Litsea genus are widely investigated due to their nutritional and medicinal purposes. In this
regard, this study is another similar sincere effort in which the antioxidant property and phytochemical composition of Litsea
garciae (L. garciae) bark’s hexane, chloroform, methanol, and aqueous extracts were evaluated to confirm its traditional
benefits. The total flavonoid content (TFC) and total phenolic content (TPC) were determined first, followed by an assessment
of in vitro antioxidant activity using the DPPH and FRAP assays. The composition of the secondary metabolites was determined
using Ultra-High-Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS). As a result, methanol extract was
recorded to have the highest TPC value aligned with its positive appearance in phytochemical screening. Its antioxidant capacity
indicated the least IC50. The results indicated that the significant free radical scavenging activity was due to the methanolic
extract’s high phenolic content. The secondary metabolites found in the methanol extract varied significantly according to
UHPLC-MS analysis. The major phenolic compounds were found including N-trans-feruloyl-4-O-methyldopamine, N-cisferuloyltyramine,
epicatechin-(4beta->6)-epicatechin-(2beta->7,4beta->8)-epicatechin, 7-Hydroxy-3-(4-methoxyphenyl)-
4-propyl-2H-1-benzopyran-2-one and 9-O-Methylneodunol. In general, the results indicate that L. garciae bark may be a
promising source of novel natural compounds with antioxidative properties. |
| first_indexed | 2025-11-15T00:40:49Z |
| format | Article |
| id | oai:generic.eprints.org:19515 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:40:49Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:195152022-08-30T00:58:24Z http://journalarticle.ukm.my/19515/ Antioxidant capabilities of Litsea garciae bark extracts and their relation to the phytochemical compositions Siti Zaleha Raduan, Qamar Uddin Ahmed, Abdul Razak Kasmuri, Muhamad Rusdi Ahmad Rusmili, Md Abdur Rashid Mia, Wan Mohd Azizi Wan Sulaiman, Muhammad Hamdi Mahmood, Mohd Farooq Shaikh, The plant species belonging to the Litsea genus are widely investigated due to their nutritional and medicinal purposes. In this regard, this study is another similar sincere effort in which the antioxidant property and phytochemical composition of Litsea garciae (L. garciae) bark’s hexane, chloroform, methanol, and aqueous extracts were evaluated to confirm its traditional benefits. The total flavonoid content (TFC) and total phenolic content (TPC) were determined first, followed by an assessment of in vitro antioxidant activity using the DPPH and FRAP assays. The composition of the secondary metabolites was determined using Ultra-High-Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS). As a result, methanol extract was recorded to have the highest TPC value aligned with its positive appearance in phytochemical screening. Its antioxidant capacity indicated the least IC50. The results indicated that the significant free radical scavenging activity was due to the methanolic extract’s high phenolic content. The secondary metabolites found in the methanol extract varied significantly according to UHPLC-MS analysis. The major phenolic compounds were found including N-trans-feruloyl-4-O-methyldopamine, N-cisferuloyltyramine, epicatechin-(4beta->6)-epicatechin-(2beta->7,4beta->8)-epicatechin, 7-Hydroxy-3-(4-methoxyphenyl)- 4-propyl-2H-1-benzopyran-2-one and 9-O-Methylneodunol. In general, the results indicate that L. garciae bark may be a promising source of novel natural compounds with antioxidative properties. Penerbit Universiti Kebangsaan Malaysia 2022 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/19515/1/10%2B-%2BANTIOXIDANT%2BCAPABILITIES%2BOF%2BLitsea%2Bgarciae%2BBARK%2BEXTRACTS%2B%281%29.pdf Siti Zaleha Raduan, and Qamar Uddin Ahmed, and Abdul Razak Kasmuri, and Muhamad Rusdi Ahmad Rusmili, and Md Abdur Rashid Mia, and Wan Mohd Azizi Wan Sulaiman, and Muhammad Hamdi Mahmood, and Mohd Farooq Shaikh, (2022) Antioxidant capabilities of Litsea garciae bark extracts and their relation to the phytochemical compositions. Malaysian Applied Biology, 51 (1). pp. 99-117. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/44 |
| spellingShingle | Siti Zaleha Raduan, Qamar Uddin Ahmed, Abdul Razak Kasmuri, Muhamad Rusdi Ahmad Rusmili, Md Abdur Rashid Mia, Wan Mohd Azizi Wan Sulaiman, Muhammad Hamdi Mahmood, Mohd Farooq Shaikh, Antioxidant capabilities of Litsea garciae bark extracts and their relation to the phytochemical compositions |
| title | Antioxidant capabilities of Litsea garciae bark extracts
and their relation to the phytochemical compositions |
| title_full | Antioxidant capabilities of Litsea garciae bark extracts
and their relation to the phytochemical compositions |
| title_fullStr | Antioxidant capabilities of Litsea garciae bark extracts
and their relation to the phytochemical compositions |
| title_full_unstemmed | Antioxidant capabilities of Litsea garciae bark extracts
and their relation to the phytochemical compositions |
| title_short | Antioxidant capabilities of Litsea garciae bark extracts
and their relation to the phytochemical compositions |
| title_sort | antioxidant capabilities of litsea garciae bark extracts
and their relation to the phytochemical compositions |
| url | http://journalarticle.ukm.my/19515/ http://journalarticle.ukm.my/19515/ http://journalarticle.ukm.my/19515/1/10%2B-%2BANTIOXIDANT%2BCAPABILITIES%2BOF%2BLitsea%2Bgarciae%2BBARK%2BEXTRACTS%2B%281%29.pdf |