The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is currently affecting 40-50 million people worldwide. It is generally recognized from its main symptom dementia, in which the patient undergoes a progressive decline in their cognitive memory. Recent studies have shown that me...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/19165/ http://journalarticle.ukm.my/19165/1/14.pdf |
| _version_ | 1848814766403878912 |
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| author | Muhammad Danial bin Che Ramli, Nur Arissa Syazwani Md Nazrey, Mahathir Mohd Uzid, Anita Zara Weinheimer, Nur Batrisyia Nizam, Nadhratun Nabila Mazlan, Nurshafiqah Najihah Mohd Mizan, Hussin Muhammad, Mohamad Anuar Ahad, Mohamad Azmeer Effendy, |
| author_facet | Muhammad Danial bin Che Ramli, Nur Arissa Syazwani Md Nazrey, Mahathir Mohd Uzid, Anita Zara Weinheimer, Nur Batrisyia Nizam, Nadhratun Nabila Mazlan, Nurshafiqah Najihah Mohd Mizan, Hussin Muhammad, Mohamad Anuar Ahad, Mohamad Azmeer Effendy, |
| author_sort | Muhammad Danial bin Che Ramli, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is currently affecting 40-50 million people worldwide. It is generally recognized from its main symptom dementia, in which the patient undergoes a progressive decline in their cognitive memory. Recent studies have shown that medicinal plants such as Clitoria ternatea equipped with antioxidant properties has high potential in treating AD. The study was conducted using zebrafish model of AD induced with aluminium chloride for 28 days. The treatment dose of C. ternatea extract (4.34 mg/L) was then given for 14 days. The behaviour of the zebrafish were evaluated through memory testing by using a T-maze test and novel tank diving test. Histological studies were also performed. 50% of the zebrafish tested showed improvement in memory through the T-maze test after treatment with C. ternatea extract. Zebrafish model of AD treated with C. ternatea extract also shows a decrease in anxiety in the novel tank diving test. A significant increase of purkinje cells were also observed from the histological study after treatment with C. ternatea extract. Nucleus elongation of oligodendrocytes from zebrafish model of AD induced with aluminium chloride were improved when treated with the C. ternatea extract. In conclusion, it was found that C. ternatea extract exhibits strong potential for treating zebrafish model of AD induced with aluminium chloride. |
| first_indexed | 2025-11-15T00:39:18Z |
| format | Article |
| id | oai:generic.eprints.org:19165 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:39:18Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:191652022-08-01T04:18:34Z http://journalarticle.ukm.my/19165/ The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study Muhammad Danial bin Che Ramli, Nur Arissa Syazwani Md Nazrey, Mahathir Mohd Uzid, Anita Zara Weinheimer, Nur Batrisyia Nizam, Nadhratun Nabila Mazlan, Nurshafiqah Najihah Mohd Mizan, Hussin Muhammad, Mohamad Anuar Ahad, Mohamad Azmeer Effendy, Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is currently affecting 40-50 million people worldwide. It is generally recognized from its main symptom dementia, in which the patient undergoes a progressive decline in their cognitive memory. Recent studies have shown that medicinal plants such as Clitoria ternatea equipped with antioxidant properties has high potential in treating AD. The study was conducted using zebrafish model of AD induced with aluminium chloride for 28 days. The treatment dose of C. ternatea extract (4.34 mg/L) was then given for 14 days. The behaviour of the zebrafish were evaluated through memory testing by using a T-maze test and novel tank diving test. Histological studies were also performed. 50% of the zebrafish tested showed improvement in memory through the T-maze test after treatment with C. ternatea extract. Zebrafish model of AD treated with C. ternatea extract also shows a decrease in anxiety in the novel tank diving test. A significant increase of purkinje cells were also observed from the histological study after treatment with C. ternatea extract. Nucleus elongation of oligodendrocytes from zebrafish model of AD induced with aluminium chloride were improved when treated with the C. ternatea extract. In conclusion, it was found that C. ternatea extract exhibits strong potential for treating zebrafish model of AD induced with aluminium chloride. Penerbit Universiti Kebangsaan Malaysia 2022-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/19165/1/14.pdf Muhammad Danial bin Che Ramli, and Nur Arissa Syazwani Md Nazrey, and Mahathir Mohd Uzid, and Anita Zara Weinheimer, and Nur Batrisyia Nizam, and Nadhratun Nabila Mazlan, and Nurshafiqah Najihah Mohd Mizan, and Hussin Muhammad, and Mohamad Anuar Ahad, and Mohamad Azmeer Effendy, (2022) The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study. Sains Malaysiana, 51 (3). pp. 803-814. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil3_2022/KandunganJilid51Bil3_2022.html |
| spellingShingle | Muhammad Danial bin Che Ramli, Nur Arissa Syazwani Md Nazrey, Mahathir Mohd Uzid, Anita Zara Weinheimer, Nur Batrisyia Nizam, Nadhratun Nabila Mazlan, Nurshafiqah Najihah Mohd Mizan, Hussin Muhammad, Mohamad Anuar Ahad, Mohamad Azmeer Effendy, The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study |
| title | The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study |
| title_full | The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study |
| title_fullStr | The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study |
| title_full_unstemmed | The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study |
| title_short | The effects of Clitoria ternatea extract on zebrafish model of Alzheimer’s disease : a neurobehavioural study |
| title_sort | effects of clitoria ternatea extract on zebrafish model of alzheimer’s disease : a neurobehavioural study |
| url | http://journalarticle.ukm.my/19165/ http://journalarticle.ukm.my/19165/ http://journalarticle.ukm.my/19165/1/14.pdf |