Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate nociceptive responses with associated changes in the thalamus. Forty...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18879/ http://journalarticle.ukm.my/18879/1/039-047%2B%2B%2BChe%2BBadariah%2BAbd%2BAziz.pdf |
| _version_ | 1848814691728490496 |
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| author | Anis Syahirah Mohd Shafie, Che Badariah Abd Aziz, Liza Noordin, Idris Long, Anani Aila Mat Zin, Rosfaiizah Siran, |
| author_facet | Anis Syahirah Mohd Shafie, Che Badariah Abd Aziz, Liza Noordin, Idris Long, Anani Aila Mat Zin, Rosfaiizah Siran, |
| author_sort | Anis Syahirah Mohd Shafie, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether
the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate
nociceptive responses with associated changes in the thalamus. Forty-eight Sprague Dawley male rats were randomised
into four groups (n=12 for each group): control group (FMC), REM sleep deprivation (REMsd), REM sleep deprivation
pretreated with Tualang Honey for 1 month (REMsdH) and tank control (TC). Following sleep deprivation for 72 hours, a
formalin test was conducted and pain behaviour was recorded and analysed. The rats were sacrificed, and the brains were
removed for histological examination and assessment of N-methyl-D-aspartate receptor (NMDA R2) level in the thalamus.
REMsdH group showed a significantly lower level of pain behaviour score and NMDA R2 compared to the REMsd group
(p<0.05). In addition, REMsdH also demonstrated a significantly higher number of Nissl stained neurons in comparison
with the REMsd group (p<0.05). Furthermore, dark neurons, suggestive of neuronal damage, were observed in the REMsd
group. In conclusion, administration of Tualang honey before REM sleep deprivation modulated nociceptive responses and
prevent changes in thalamic neurons and NMDA R2 level. |
| first_indexed | 2025-11-15T00:38:07Z |
| format | Article |
| id | oai:generic.eprints.org:18879 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:38:07Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:188792022-07-05T07:38:35Z http://journalarticle.ukm.my/18879/ Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model Anis Syahirah Mohd Shafie, Che Badariah Abd Aziz, Liza Noordin, Idris Long, Anani Aila Mat Zin, Rosfaiizah Siran, Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate nociceptive responses with associated changes in the thalamus. Forty-eight Sprague Dawley male rats were randomised into four groups (n=12 for each group): control group (FMC), REM sleep deprivation (REMsd), REM sleep deprivation pretreated with Tualang Honey for 1 month (REMsdH) and tank control (TC). Following sleep deprivation for 72 hours, a formalin test was conducted and pain behaviour was recorded and analysed. The rats were sacrificed, and the brains were removed for histological examination and assessment of N-methyl-D-aspartate receptor (NMDA R2) level in the thalamus. REMsdH group showed a significantly lower level of pain behaviour score and NMDA R2 compared to the REMsd group (p<0.05). In addition, REMsdH also demonstrated a significantly higher number of Nissl stained neurons in comparison with the REMsd group (p<0.05). Furthermore, dark neurons, suggestive of neuronal damage, were observed in the REMsd group. In conclusion, administration of Tualang honey before REM sleep deprivation modulated nociceptive responses and prevent changes in thalamic neurons and NMDA R2 level. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18879/1/039-047%2B%2B%2BChe%2BBadariah%2BAbd%2BAziz.pdf Anis Syahirah Mohd Shafie, and Che Badariah Abd Aziz, and Liza Noordin, and Idris Long, and Anani Aila Mat Zin, and Rosfaiizah Siran, (2021) Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model. Malaysian Applied Biology, 50 (3). pp. 39-47. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/43 |
| spellingShingle | Anis Syahirah Mohd Shafie, Che Badariah Abd Aziz, Liza Noordin, Idris Long, Anani Aila Mat Zin, Rosfaiizah Siran, Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model |
| title | Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model |
| title_full | Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model |
| title_fullStr | Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model |
| title_full_unstemmed | Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model |
| title_short | Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model |
| title_sort | tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model |
| url | http://journalarticle.ukm.my/18879/ http://journalarticle.ukm.my/18879/ http://journalarticle.ukm.my/18879/1/039-047%2B%2B%2BChe%2BBadariah%2BAbd%2BAziz.pdf |