The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model
Segmental bone allografts are widely used in managing large cortical bone defects. To improve host-graft union, the effect of allograft on a large cortical tibial bone defect augmented with a non-vascularized periosteal flap was studied. Twelve mature Australian white rabbits (Oryctolagus cuniculu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18813/ http://journalarticle.ukm.my/18813/1/047-053%2B%2B%2BMohd%2BAriff%2BSharifudin.pdf |
| _version_ | 1848814673233707008 |
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| author | Azuhairy Azid, Mohd Ariff Sharifudin, Zulmi Wan, Mohd Shafie Abdullah, Hasnan Jaafar, |
| author_facet | Azuhairy Azid, Mohd Ariff Sharifudin, Zulmi Wan, Mohd Shafie Abdullah, Hasnan Jaafar, |
| author_sort | Azuhairy Azid, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Segmental bone allografts are widely used in managing large cortical bone defects. To improve host-graft union, the effect
of allograft on a large cortical tibial bone defect augmented with a non-vascularized periosteal flap was studied. Twelve
mature Australian white rabbits (Oryctolagus cuniculus) were divided into intervention groups and a control group. Bone
defects in the intervention groups were treated with segmental allografts wrapped with a non-vascularized periosteal flap.
The control group was treated with allograft transplantation alone. Healing was evaluated at the end of the 2nd, 4th, and 6th
weeks with plain radiographs, CT scan, and histology. In the intervention groups, the bony union was achieved at both
ends of the allografts at the 4th to 6th weeks. Solid callus encasing the whole allograft segments at the end of the 6th week. In
the control group, the union did not occur at both ends of the allograft segments even up to the end of the 6th week. No
callus formation surrounding the allograft segments. Fragmentation and telescoping of the allograft segment into the medullary
cavity of the host were observed. The use of autogenous, non-vascularized periosteal flap modified the healing process of
allograft and maintained the integrity of the allograft. |
| first_indexed | 2025-11-15T00:37:49Z |
| format | Article |
| id | oai:generic.eprints.org:18813 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:37:49Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:188132022-06-24T00:36:18Z http://journalarticle.ukm.my/18813/ The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model Azuhairy Azid, Mohd Ariff Sharifudin, Zulmi Wan, Mohd Shafie Abdullah, Hasnan Jaafar, Segmental bone allografts are widely used in managing large cortical bone defects. To improve host-graft union, the effect of allograft on a large cortical tibial bone defect augmented with a non-vascularized periosteal flap was studied. Twelve mature Australian white rabbits (Oryctolagus cuniculus) were divided into intervention groups and a control group. Bone defects in the intervention groups were treated with segmental allografts wrapped with a non-vascularized periosteal flap. The control group was treated with allograft transplantation alone. Healing was evaluated at the end of the 2nd, 4th, and 6th weeks with plain radiographs, CT scan, and histology. In the intervention groups, the bony union was achieved at both ends of the allografts at the 4th to 6th weeks. Solid callus encasing the whole allograft segments at the end of the 6th week. In the control group, the union did not occur at both ends of the allograft segments even up to the end of the 6th week. No callus formation surrounding the allograft segments. Fragmentation and telescoping of the allograft segment into the medullary cavity of the host were observed. The use of autogenous, non-vascularized periosteal flap modified the healing process of allograft and maintained the integrity of the allograft. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18813/1/047-053%2B%2B%2BMohd%2BAriff%2BSharifudin.pdf Azuhairy Azid, and Mohd Ariff Sharifudin, and Zulmi Wan, and Mohd Shafie Abdullah, and Hasnan Jaafar, (2021) The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model. Malaysian Applied Biology, 50 (2). pp. 47-53. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/36 |
| spellingShingle | Azuhairy Azid, Mohd Ariff Sharifudin, Zulmi Wan, Mohd Shafie Abdullah, Hasnan Jaafar, The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model |
| title | The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model |
| title_full | The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model |
| title_fullStr | The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model |
| title_full_unstemmed | The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model |
| title_short | The effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model |
| title_sort | effect of autogenous, non-vascularized periosteum transplantation on allograft bone grafting for large cortical load-bearing bone defect – a rabbit model |
| url | http://journalarticle.ukm.my/18813/ http://journalarticle.ukm.my/18813/ http://journalarticle.ukm.my/18813/1/047-053%2B%2B%2BMohd%2BAriff%2BSharifudin.pdf |