The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma
Programmed death 1 (PD-1) protein and its ligands, PD-L1 are two proteins that have been widely studied in many solid tumours. However, only limited observations were made in lymphomas, which were mainly Hodgkin lymphomas. We aimed to evaluate the expressions of PD-1 in the tumour microenvironment...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18811/ http://journalarticle.ukm.my/18811/1/025-035%2B%2B%2BFaezahtul%2BArbaeyah%2BHussain.pdf |
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| author | Farhana Mohammad Mohaidin, Pavitratha Puspanathan, Nur Asyilla Che Jalil, Faezahtul Arbaeyah Hussain, |
| author_facet | Farhana Mohammad Mohaidin, Pavitratha Puspanathan, Nur Asyilla Che Jalil, Faezahtul Arbaeyah Hussain, |
| author_sort | Farhana Mohammad Mohaidin, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Programmed death 1 (PD-1) protein and its ligands, PD-L1 are two proteins that have been widely studied in many solid
tumours. However, only limited observations were made in lymphomas, which were mainly Hodgkin lymphomas. We
aimed to evaluate the expressions of PD-1 in the tumour microenvironment and PD-L1 in the tumour cells of primary
extranodal non-Hodgkin lymphoma (peNHL). A cross-sectional study using 87 archived formalin-fixed paraffin-embedded
tissue blocks from patients diagnosed with peNHL. Immunohistochemistry stainings for PD-1 and PD-L1 were done. The
protein expressions were evaluated microscopically. The association between expressions of the PD-1 and PD-L1 with the
histological subtypes of peNHL were statistically analysed. 46 (52.9%) of the cases had a negative expression of PD-L1 in
the tumour cells and 57 (65.5%) had positive PD-1 expression in the tumour microenvironment. Significant associations
were found between PD-1 and PD-L1 expressions with subtypes of peNHL (p<0.05). Positive expressions of both proteins
were found in diffuse large B cell lymphoma (DLBCL). Our study explored the expressions of PD-1 and PD-L1 in peNHL
that has demonstrated a significant association of PD-1 and PD-L1 expressions with subtypes of peNHL, which may
provide additional information to the future study of these proteins. |
| first_indexed | 2025-11-15T00:37:49Z |
| format | Article |
| id | oai:generic.eprints.org:18811 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:37:49Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:188112022-06-24T00:34:39Z http://journalarticle.ukm.my/18811/ The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma Farhana Mohammad Mohaidin, Pavitratha Puspanathan, Nur Asyilla Che Jalil, Faezahtul Arbaeyah Hussain, Programmed death 1 (PD-1) protein and its ligands, PD-L1 are two proteins that have been widely studied in many solid tumours. However, only limited observations were made in lymphomas, which were mainly Hodgkin lymphomas. We aimed to evaluate the expressions of PD-1 in the tumour microenvironment and PD-L1 in the tumour cells of primary extranodal non-Hodgkin lymphoma (peNHL). A cross-sectional study using 87 archived formalin-fixed paraffin-embedded tissue blocks from patients diagnosed with peNHL. Immunohistochemistry stainings for PD-1 and PD-L1 were done. The protein expressions were evaluated microscopically. The association between expressions of the PD-1 and PD-L1 with the histological subtypes of peNHL were statistically analysed. 46 (52.9%) of the cases had a negative expression of PD-L1 in the tumour cells and 57 (65.5%) had positive PD-1 expression in the tumour microenvironment. Significant associations were found between PD-1 and PD-L1 expressions with subtypes of peNHL (p<0.05). Positive expressions of both proteins were found in diffuse large B cell lymphoma (DLBCL). Our study explored the expressions of PD-1 and PD-L1 in peNHL that has demonstrated a significant association of PD-1 and PD-L1 expressions with subtypes of peNHL, which may provide additional information to the future study of these proteins. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18811/1/025-035%2B%2B%2BFaezahtul%2BArbaeyah%2BHussain.pdf Farhana Mohammad Mohaidin, and Pavitratha Puspanathan, and Nur Asyilla Che Jalil, and Faezahtul Arbaeyah Hussain, (2021) The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma. Malaysian Applied Biology, 50 (2). pp. 25-35. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/36 |
| spellingShingle | Farhana Mohammad Mohaidin, Pavitratha Puspanathan, Nur Asyilla Che Jalil, Faezahtul Arbaeyah Hussain, The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma |
| title | The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma |
| title_full | The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma |
| title_fullStr | The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma |
| title_full_unstemmed | The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma |
| title_short | The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma |
| title_sort | evaluation of program death 1 (pd-1) and pd-1 ligand (pd-l1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma |
| url | http://journalarticle.ukm.my/18811/ http://journalarticle.ukm.my/18811/ http://journalarticle.ukm.my/18811/1/025-035%2B%2B%2BFaezahtul%2BArbaeyah%2BHussain.pdf |