The evaluation of program death 1 (PD-1) and PD-1 ligand (PD-L1) expressions in histological subtypes of primary extranodal non-hodgkin lymphoma
Programmed death 1 (PD-1) protein and its ligands, PD-L1 are two proteins that have been widely studied in many solid tumours. However, only limited observations were made in lymphomas, which were mainly Hodgkin lymphomas. We aimed to evaluate the expressions of PD-1 in the tumour microenvironment...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18811/ http://journalarticle.ukm.my/18811/1/025-035%2B%2B%2BFaezahtul%2BArbaeyah%2BHussain.pdf |
| Summary: | Programmed death 1 (PD-1) protein and its ligands, PD-L1 are two proteins that have been widely studied in many solid
tumours. However, only limited observations were made in lymphomas, which were mainly Hodgkin lymphomas. We
aimed to evaluate the expressions of PD-1 in the tumour microenvironment and PD-L1 in the tumour cells of primary
extranodal non-Hodgkin lymphoma (peNHL). A cross-sectional study using 87 archived formalin-fixed paraffin-embedded
tissue blocks from patients diagnosed with peNHL. Immunohistochemistry stainings for PD-1 and PD-L1 were done. The
protein expressions were evaluated microscopically. The association between expressions of the PD-1 and PD-L1 with the
histological subtypes of peNHL were statistically analysed. 46 (52.9%) of the cases had a negative expression of PD-L1 in
the tumour cells and 57 (65.5%) had positive PD-1 expression in the tumour microenvironment. Significant associations
were found between PD-1 and PD-L1 expressions with subtypes of peNHL (p<0.05). Positive expressions of both proteins
were found in diffuse large B cell lymphoma (DLBCL). Our study explored the expressions of PD-1 and PD-L1 in peNHL
that has demonstrated a significant association of PD-1 and PD-L1 expressions with subtypes of peNHL, which may
provide additional information to the future study of these proteins. |
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