Reactive Oxygen Species (ROS) in cancer and cancer stem cells
Reactive Oxygen Species (ROS) are aerobic metabolic byproducts, mainly produced by mitochondria. Most types of cancer contain high amounts of ROS. An increase in endogenous ROS triggers adaptive changes, induces oxidative stress and cytotoxic. Oxidative stress can lead to cancer. But on the other ha...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18584/ http://journalarticle.ukm.my/18584/1/40519-160182-1-PB.pdf |
| _version_ | 1848814612571488256 |
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| author | Hikmah, Febrial Hardiany, Novi Silvia |
| author_facet | Hikmah, Febrial Hardiany, Novi Silvia |
| author_sort | Hikmah, Febrial |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Reactive Oxygen Species (ROS) are aerobic metabolic byproducts, mainly produced by mitochondria. Most types of cancer contain high amounts of ROS. An increase in endogenous ROS triggers adaptive changes, induces oxidative stress and cytotoxic. Oxidative stress can lead to cancer. But on the other hand, the radiotherapy treatment method induces the formation of ROS in the process of cell death. Resistance therapy in cancer cells is associated with high antioxidant enzymes that neutralize ROS in cancer cells. In addition, therapeutic resistance and recurrence are also associated with the presence of cancer stem cells (CSCs). Several studies have shown that ROS levels are found to be low in CSCs. Low levels of ROS are likely to play a role in the survival of CSCs. Therefore, modulation of ROS levels in CSCs can be used as an alternative therapy. |
| first_indexed | 2025-11-15T00:36:51Z |
| format | Article |
| id | oai:generic.eprints.org:18584 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:36:51Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:185842022-05-17T06:53:43Z http://journalarticle.ukm.my/18584/ Reactive Oxygen Species (ROS) in cancer and cancer stem cells Hikmah, Febrial Hardiany, Novi Silvia Reactive Oxygen Species (ROS) are aerobic metabolic byproducts, mainly produced by mitochondria. Most types of cancer contain high amounts of ROS. An increase in endogenous ROS triggers adaptive changes, induces oxidative stress and cytotoxic. Oxidative stress can lead to cancer. But on the other hand, the radiotherapy treatment method induces the formation of ROS in the process of cell death. Resistance therapy in cancer cells is associated with high antioxidant enzymes that neutralize ROS in cancer cells. In addition, therapeutic resistance and recurrence are also associated with the presence of cancer stem cells (CSCs). Several studies have shown that ROS levels are found to be low in CSCs. Low levels of ROS are likely to play a role in the survival of CSCs. Therefore, modulation of ROS levels in CSCs can be used as an alternative therapy. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18584/1/40519-160182-1-PB.pdf Hikmah, Febrial and Hardiany, Novi Silvia (2021) Reactive Oxygen Species (ROS) in cancer and cancer stem cells. Jurnal Sains Kesihatan Malaysia, 19 (2). pp. 39-45. ISSN 1675-8161 https://ejournal.ukm.my/jskm/issue/view/1355 |
| spellingShingle | Hikmah, Febrial Hardiany, Novi Silvia Reactive Oxygen Species (ROS) in cancer and cancer stem cells |
| title | Reactive Oxygen Species (ROS) in cancer and cancer stem cells |
| title_full | Reactive Oxygen Species (ROS) in cancer and cancer stem cells |
| title_fullStr | Reactive Oxygen Species (ROS) in cancer and cancer stem cells |
| title_full_unstemmed | Reactive Oxygen Species (ROS) in cancer and cancer stem cells |
| title_short | Reactive Oxygen Species (ROS) in cancer and cancer stem cells |
| title_sort | reactive oxygen species (ros) in cancer and cancer stem cells |
| url | http://journalarticle.ukm.my/18584/ http://journalarticle.ukm.my/18584/ http://journalarticle.ukm.my/18584/1/40519-160182-1-PB.pdf |