Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption
Ethanol cannot be excreted and must be metabolized in the liver. Alcoholic liver disease is a blanket term for conditions related specifically to the liver and alcohol use. The study aimed to evaluate the metabolic, biochemical and histological effects of the oral supplementation with β-carotene on...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2022
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| Online Access: | http://journalarticle.ukm.my/18365/ http://journalarticle.ukm.my/18365/1/23.pdf |
| _version_ | 1848814553484230656 |
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| author | Sandoval, Cristian Vásquez, Bélgica Vasconcellos, Adriana Souza-Mello, Vanessa Adeli, Khosrow Mandarim-de-Lacerda, Carlos del Sol, Mariano |
| author_facet | Sandoval, Cristian Vásquez, Bélgica Vasconcellos, Adriana Souza-Mello, Vanessa Adeli, Khosrow Mandarim-de-Lacerda, Carlos del Sol, Mariano |
| author_sort | Sandoval, Cristian |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Ethanol cannot be excreted and must be metabolized in the liver. Alcoholic liver disease is a blanket term for conditions related specifically to the liver and alcohol use. The study aimed to evaluate the metabolic, biochemical and histological effects of the oral supplementation with β-carotene on the liver of C57BL/6 mice exposed to ethanol consumption. Thirty male C57BL/6 mice (Mus musculus) were divided into six experimental groups: Control (C), Low-dose alcohol (LA), Moderate-dose alcohol (MA), β-carotene (B), Low-dose alcohol+β-carotene (LA+B) and Moderate-dose alcohol+β-carotene (MA+B) group. One-way ANOVA was used. The greatest intake of calories was noted in the LA (65.4 ± 12.5 kJ) and MA (68.6 ± 18.6 kJ) groups. The LA+B and MA+B groups shown an improvement in the HOMA-IR index (8.7 ± 2.4 and 6.7 ± 3.5, respectively), increased ADH levels (16.2 ± 1.6 and 18.9 ± 0.5 pmol/minmL-1, respectively) and decreased insulin levels (14.0 ± 3.3 and 10.6 ± 5.7 μUmL-1, respectively). It was also observed that oral supplementation with β-carotene improved the hepatic parenchyma in the LA+B group, showing normal-sized hepatocytes, whereas in the MA+B group it relieved the structural damage, revealing fewer lipid droplets than the MA group. |
| first_indexed | 2025-11-15T00:35:55Z |
| format | Article |
| id | oai:generic.eprints.org:18365 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:35:55Z |
| publishDate | 2022 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:183652022-04-11T07:28:19Z http://journalarticle.ukm.my/18365/ Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption Sandoval, Cristian Vásquez, Bélgica Vasconcellos, Adriana Souza-Mello, Vanessa Adeli, Khosrow Mandarim-de-Lacerda, Carlos del Sol, Mariano Ethanol cannot be excreted and must be metabolized in the liver. Alcoholic liver disease is a blanket term for conditions related specifically to the liver and alcohol use. The study aimed to evaluate the metabolic, biochemical and histological effects of the oral supplementation with β-carotene on the liver of C57BL/6 mice exposed to ethanol consumption. Thirty male C57BL/6 mice (Mus musculus) were divided into six experimental groups: Control (C), Low-dose alcohol (LA), Moderate-dose alcohol (MA), β-carotene (B), Low-dose alcohol+β-carotene (LA+B) and Moderate-dose alcohol+β-carotene (MA+B) group. One-way ANOVA was used. The greatest intake of calories was noted in the LA (65.4 ± 12.5 kJ) and MA (68.6 ± 18.6 kJ) groups. The LA+B and MA+B groups shown an improvement in the HOMA-IR index (8.7 ± 2.4 and 6.7 ± 3.5, respectively), increased ADH levels (16.2 ± 1.6 and 18.9 ± 0.5 pmol/minmL-1, respectively) and decreased insulin levels (14.0 ± 3.3 and 10.6 ± 5.7 μUmL-1, respectively). It was also observed that oral supplementation with β-carotene improved the hepatic parenchyma in the LA+B group, showing normal-sized hepatocytes, whereas in the MA+B group it relieved the structural damage, revealing fewer lipid droplets than the MA group. Penerbit Universiti Kebangsaan Malaysia 2022-01 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18365/1/23.pdf Sandoval, Cristian and Vásquez, Bélgica and Vasconcellos, Adriana and Souza-Mello, Vanessa and Adeli, Khosrow and Mandarim-de-Lacerda, Carlos and del Sol, Mariano (2022) Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption. Sains Malaysiana, 51 (1). pp. 285-296. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil1_2022/KandunganJilid51Bil1_2022.html |
| spellingShingle | Sandoval, Cristian Vásquez, Bélgica Vasconcellos, Adriana Souza-Mello, Vanessa Adeli, Khosrow Mandarim-de-Lacerda, Carlos del Sol, Mariano Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption |
| title | Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption |
| title_full | Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption |
| title_fullStr | Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption |
| title_full_unstemmed | Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption |
| title_short | Oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (Mus musculus) exposed to a chronic ethanol consumption |
| title_sort | oral supplementation of β-carotene benefits the hepatic structure and metabolism in mice (mus musculus) exposed to a chronic ethanol consumption |
| url | http://journalarticle.ukm.my/18365/ http://journalarticle.ukm.my/18365/ http://journalarticle.ukm.my/18365/1/23.pdf |