Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia
Tracheal extubation carries higher complication rates compared to intubation during general anaesthesia (GA). Thus, various drugs are used to attenuate hemodynamic responses and cough reflex during extubation. We investigated if intravenous (IV) lignocaine and esmolol, given prior extubation,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Pusat Perubatan Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18268/ http://journalarticle.ukm.my/18268/1/6_ms0486_pdf_10044.pdf |
| _version_ | 1848814526735056896 |
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| author | Ng, CY Liu, CY Cheah, SK Ooi, Joanna Su Min Rufinah Teo, |
| author_facet | Ng, CY Liu, CY Cheah, SK Ooi, Joanna Su Min Rufinah Teo, |
| author_sort | Ng, CY |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Tracheal extubation carries higher complication rates compared to intubation during
general anaesthesia (GA). Thus, various drugs are used to attenuate hemodynamic
responses and cough reflex during extubation. We investigated if intravenous
(IV) lignocaine and esmolol, given prior extubation, was able to achieve that in
hypertensive patients under GA. In this prospective, double-blinded, randomised
controlled study, 68 hypertensive patients on treatment undergoing GA were
analysed. Group L received IV lignocaine 1 mg/kg while Group E received IV
esmolol 1.5 mg/kg, 2 minutes before extubation. Heart rate (HR), systolic blood
pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP)
were recorded at the following interval: before study drug administration (T-0),
prior extubation (T-1), 1 minute (T-2), 3 minutes (T-3), 5 minutes (T-4) and 10
minutes (T-5) post-extubation. Group L showed significantly increase in HR at T-2
while SBP and MAP increased significantly from T-1 until T-5. Group E showed
a significant reduction in HR at T-1 up to T-5 and significantly lower HR at T-1
and T-2 compared to Group L. Group E showed stable SBP, DBP and MAP at
all intervals. In conclusion, IV esmolol at 1.5 mg/kg was able to attenuate the
hemodynamic response more pronounced when compared to IV lignocaine at
1 mg/kg from extubation stress in patients with hypertension on treatment. Both
lignocaine and esmolol were equally effective in suppressing cough reflex during
extubation. |
| first_indexed | 2025-11-15T00:35:29Z |
| format | Article |
| id | oai:generic.eprints.org:18268 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:35:29Z |
| publishDate | 2021 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:182682022-03-25T01:42:59Z http://journalarticle.ukm.my/18268/ Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia Ng, CY Liu, CY Cheah, SK Ooi, Joanna Su Min Rufinah Teo, Tracheal extubation carries higher complication rates compared to intubation during general anaesthesia (GA). Thus, various drugs are used to attenuate hemodynamic responses and cough reflex during extubation. We investigated if intravenous (IV) lignocaine and esmolol, given prior extubation, was able to achieve that in hypertensive patients under GA. In this prospective, double-blinded, randomised controlled study, 68 hypertensive patients on treatment undergoing GA were analysed. Group L received IV lignocaine 1 mg/kg while Group E received IV esmolol 1.5 mg/kg, 2 minutes before extubation. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were recorded at the following interval: before study drug administration (T-0), prior extubation (T-1), 1 minute (T-2), 3 minutes (T-3), 5 minutes (T-4) and 10 minutes (T-5) post-extubation. Group L showed significantly increase in HR at T-2 while SBP and MAP increased significantly from T-1 until T-5. Group E showed a significant reduction in HR at T-1 up to T-5 and significantly lower HR at T-1 and T-2 compared to Group L. Group E showed stable SBP, DBP and MAP at all intervals. In conclusion, IV esmolol at 1.5 mg/kg was able to attenuate the hemodynamic response more pronounced when compared to IV lignocaine at 1 mg/kg from extubation stress in patients with hypertension on treatment. Both lignocaine and esmolol were equally effective in suppressing cough reflex during extubation. Pusat Perubatan Universiti Kebangsaan Malaysia 2021-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18268/1/6_ms0486_pdf_10044.pdf Ng, CY and Liu, CY and Cheah, SK and Ooi, Joanna Su Min and Rufinah Teo, (2021) Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia. Medicine & Health, 16 (2). pp. 84-95. ISSN 2289-5728 https://medicineandhealthukm.com/toc/16/2 |
| spellingShingle | Ng, CY Liu, CY Cheah, SK Ooi, Joanna Su Min Rufinah Teo, Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia |
| title | Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia |
| title_full | Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia |
| title_fullStr | Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia |
| title_full_unstemmed | Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia |
| title_short | Comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia |
| title_sort | comparison of intravenous lignocaine and esmolol in attenuating hemodynamic response and cough reflex during extubation in hypertensive patients under general anaesthesia |
| url | http://journalarticle.ukm.my/18268/ http://journalarticle.ukm.my/18268/ http://journalarticle.ukm.my/18268/1/6_ms0486_pdf_10044.pdf |