Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway
The anticancer and anti-inflammatory activities of wild-sage (Lantana camara) leaves essential oil were evaluated against various human cell lines. In this regard, steam hydro-distillation technique was used for oil extraction. Chemical characterization of L. camara essential oil (LCEO) was done by...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18165/ http://journalarticle.ukm.my/18165/1/7.pdf |
| _version_ | 1848814499771973632 |
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| author | Sajid, Arfaa Manzoor, Qaisar Sajid, Anam Ahmad, Rabia Shabir Hussain, Ghulam Imran, Muhammad Aslam, Farhan Arshad, Muhammad Umair Gondal, Tanweer Aslam Imran, Ali |
| author_facet | Sajid, Arfaa Manzoor, Qaisar Sajid, Anam Ahmad, Rabia Shabir Hussain, Ghulam Imran, Muhammad Aslam, Farhan Arshad, Muhammad Umair Gondal, Tanweer Aslam Imran, Ali |
| author_sort | Sajid, Arfaa |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The anticancer and anti-inflammatory activities of wild-sage (Lantana camara) leaves essential oil were evaluated against various human cell lines. In this regard, steam hydro-distillation technique was used for oil extraction. Chemical characterization of L. camara essential oil (LCEO) was done by GC-MS, and forty one chemical components (98.69%) were detected in leaves of LCEO. The major constituents were caryophyllene oxide (19.63%), caryophyllene (6.68%), β-phellandrene (6.48%), humulene epoxide II (5.68%), spathulenol (4.17%), α-pinene (3.27%), eucalyptol (3.09%), α-cyclocitral (2.89%), β-pinene (2.38%), and nerolidol II (2.33%). Moreover, the antioxidant and antimicrobial potential of LCEO were also examined. LCEO also showed good anti-inflammatory activity. Interestingly, it was found that the L. camara essential oil was active against a set of microbial strains along with promising antioxidant activity. The MTT assay showed that LCEO possessed good anticancer potential against U-266, A-549, HCT-116, SCC-4, MiaPaCa 2, and KBM-5 cancer cell lines. In these cell lines, it was depicted that the LCEO blocked the tumor cell proliferation via NF-κB pathway suppression. The promising and potent bioactivities of LCEO support the candidature of these essential oils as an anticancer agent. |
| first_indexed | 2025-11-15T00:35:04Z |
| format | Article |
| id | oai:generic.eprints.org:18165 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:35:04Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:181652022-03-07T01:58:02Z http://journalarticle.ukm.my/18165/ Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway Sajid, Arfaa Manzoor, Qaisar Sajid, Anam Ahmad, Rabia Shabir Hussain, Ghulam Imran, Muhammad Aslam, Farhan Arshad, Muhammad Umair Gondal, Tanweer Aslam Imran, Ali The anticancer and anti-inflammatory activities of wild-sage (Lantana camara) leaves essential oil were evaluated against various human cell lines. In this regard, steam hydro-distillation technique was used for oil extraction. Chemical characterization of L. camara essential oil (LCEO) was done by GC-MS, and forty one chemical components (98.69%) were detected in leaves of LCEO. The major constituents were caryophyllene oxide (19.63%), caryophyllene (6.68%), β-phellandrene (6.48%), humulene epoxide II (5.68%), spathulenol (4.17%), α-pinene (3.27%), eucalyptol (3.09%), α-cyclocitral (2.89%), β-pinene (2.38%), and nerolidol II (2.33%). Moreover, the antioxidant and antimicrobial potential of LCEO were also examined. LCEO also showed good anti-inflammatory activity. Interestingly, it was found that the L. camara essential oil was active against a set of microbial strains along with promising antioxidant activity. The MTT assay showed that LCEO possessed good anticancer potential against U-266, A-549, HCT-116, SCC-4, MiaPaCa 2, and KBM-5 cancer cell lines. In these cell lines, it was depicted that the LCEO blocked the tumor cell proliferation via NF-κB pathway suppression. The promising and potent bioactivities of LCEO support the candidature of these essential oils as an anticancer agent. Penerbit Universiti Kebangsaan Malaysia 2021-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18165/1/7.pdf Sajid, Arfaa and Manzoor, Qaisar and Sajid, Anam and Ahmad, Rabia Shabir and Hussain, Ghulam and Imran, Muhammad and Aslam, Farhan and Arshad, Muhammad Umair and Gondal, Tanweer Aslam and Imran, Ali (2021) Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway. Sains Malaysiana, 50 (10). pp. 2923-2936. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil10_2021/KandunganJilid50Bil10_2021.html |
| spellingShingle | Sajid, Arfaa Manzoor, Qaisar Sajid, Anam Ahmad, Rabia Shabir Hussain, Ghulam Imran, Muhammad Aslam, Farhan Arshad, Muhammad Umair Gondal, Tanweer Aslam Imran, Ali Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway |
| title | Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway |
| title_full | Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway |
| title_fullStr | Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway |
| title_full_unstemmed | Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway |
| title_short | Essential oil and leaves from Lantana camara significantly ameliorate different cancer cell lines by suppressing the NF-κB pathway |
| title_sort | essential oil and leaves from lantana camara significantly ameliorate different cancer cell lines by suppressing the nf-κb pathway |
| url | http://journalarticle.ukm.my/18165/ http://journalarticle.ukm.my/18165/ http://journalarticle.ukm.my/18165/1/7.pdf |