Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne
Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
|
| Online Access: | http://journalarticle.ukm.my/18063/ http://journalarticle.ukm.my/18063/1/14.pdf |
| _version_ | 1848814473467396096 |
|---|---|
| author | Dini, Iwan Soekamto, Nunuk Hariani Firdaus, Supratman, Unang Jalifah Latip, |
| author_facet | Dini, Iwan Soekamto, Nunuk Hariani Firdaus, Supratman, Unang Jalifah Latip, |
| author_sort | Dini, Iwan |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 μg/mL. |
| first_indexed | 2025-11-15T00:34:39Z |
| format | Article |
| id | oai:generic.eprints.org:18063 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:34:39Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:180632022-02-18T00:48:17Z http://journalarticle.ukm.my/18063/ Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne Dini, Iwan Soekamto, Nunuk Hariani Firdaus, Supratman, Unang Jalifah Latip, Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 μg/mL. Penerbit Universiti Kebangsaan Malaysia 2021-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18063/1/14.pdf Dini, Iwan and Soekamto, Nunuk Hariani and Firdaus, and Supratman, Unang and Jalifah Latip, (2021) Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne. Sains Malaysiana, 50 (9). pp. 2663-2674. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil9_2021/KandunganJilid50Bil9_2021.html |
| spellingShingle | Dini, Iwan Soekamto, Nunuk Hariani Firdaus, Supratman, Unang Jalifah Latip, Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne |
| title | Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne |
| title_full | Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne |
| title_fullStr | Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne |
| title_full_unstemmed | Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne |
| title_short | Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea decaisne |
| title_sort | alkaloid caulerpin and cytotoxic activity against ncl-h460 lung cancer cells isolated along with β-sitosterol from the halimeda cylindracea decaisne |
| url | http://journalarticle.ukm.my/18063/ http://journalarticle.ukm.my/18063/ http://journalarticle.ukm.my/18063/1/14.pdf |