Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia
The Dayak tribe are the indigenous people of West Kutai, East Kalimantan, Indonesia, and they have experiences in using plants for traditional medicine and the commonly used plants include Baccaurea macrocarpa (Miq.) Müll.Arg., Entada phaseoloides (L.) Merr., Goniothalamus macrophyllus (Blume) Hook....
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17578/ http://journalarticle.ukm.my/17578/1/5.pdf |
| _version_ | 1848814348104892416 |
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| author | Franxisca Mariani, Rachaneekorn Tammachote, Kusuma, Irawan Wijaya Warinthorn Chavasiri, Hunsa Punnapayak, Sehanat Prasongsuk, |
| author_facet | Franxisca Mariani, Rachaneekorn Tammachote, Kusuma, Irawan Wijaya Warinthorn Chavasiri, Hunsa Punnapayak, Sehanat Prasongsuk, |
| author_sort | Franxisca Mariani, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | The Dayak tribe are the indigenous people of West Kutai, East Kalimantan, Indonesia, and they have experiences in using plants for traditional medicine and the commonly used plants include Baccaurea macrocarpa (Miq.) Müll.Arg., Entada phaseoloides (L.) Merr., Goniothalamus macrophyllus (Blume) Hook.f. & Thomson, Gynura crepidioides Benth., Helicia robusta (Roxb.) R. Br var. robusta, Litsea elliptica, Pogostemon cablin (Blanco) Benth, and Rhodomyrtus tomentosa (Aiton) Hassk. Therefore, the present study aimed to analyze these plant species for their phenolic content, and antioxidant, antibacterial, anti-tyrosinase, and anticancer activities. The total phenolic content and total antioxidant capacity were analyzed using Folin-Ciocalteu reagent and the phosphomolybdenum method, respectively. The antioxidant activities were evaluated by DPPH and ABTS assays. The antibacterial activity was determined by agar well diffusion and microdilution methods against six bacterial strains. The anticancer activity of the plant extracts was assayed against MDA-MB-231 human breast cancer cells. Based on the ethanol extraction, the highest yield was obtained from L. elliptica (10.42%), while H. robusta extract contained the highest phenolic content, antioxidant capacity, and antioxidant activities. All the extracts exhibited antibacterial activities against all the tested strains of bacteria, with the highest activity found in R. tomentosa extract, which also showed the highest activity against the cancer cells. The ethanol extract from E. phaseoloides exhibited tyrosinase inhibition activity (IC50 = 543.83 ± 51.06 μg/mL). The results herein suggested that the ethanol extracts from some medicinal plants from East Kalimantan have potential as antioxidant, antibacterial, anticancer, and anti-tyrosinase agents. |
| first_indexed | 2025-11-15T00:32:39Z |
| format | Article |
| id | oai:generic.eprints.org:17578 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:32:39Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:175782021-11-19T01:28:10Z http://journalarticle.ukm.my/17578/ Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia Franxisca Mariani, Rachaneekorn Tammachote, Kusuma, Irawan Wijaya Warinthorn Chavasiri, Hunsa Punnapayak, Sehanat Prasongsuk, The Dayak tribe are the indigenous people of West Kutai, East Kalimantan, Indonesia, and they have experiences in using plants for traditional medicine and the commonly used plants include Baccaurea macrocarpa (Miq.) Müll.Arg., Entada phaseoloides (L.) Merr., Goniothalamus macrophyllus (Blume) Hook.f. & Thomson, Gynura crepidioides Benth., Helicia robusta (Roxb.) R. Br var. robusta, Litsea elliptica, Pogostemon cablin (Blanco) Benth, and Rhodomyrtus tomentosa (Aiton) Hassk. Therefore, the present study aimed to analyze these plant species for their phenolic content, and antioxidant, antibacterial, anti-tyrosinase, and anticancer activities. The total phenolic content and total antioxidant capacity were analyzed using Folin-Ciocalteu reagent and the phosphomolybdenum method, respectively. The antioxidant activities were evaluated by DPPH and ABTS assays. The antibacterial activity was determined by agar well diffusion and microdilution methods against six bacterial strains. The anticancer activity of the plant extracts was assayed against MDA-MB-231 human breast cancer cells. Based on the ethanol extraction, the highest yield was obtained from L. elliptica (10.42%), while H. robusta extract contained the highest phenolic content, antioxidant capacity, and antioxidant activities. All the extracts exhibited antibacterial activities against all the tested strains of bacteria, with the highest activity found in R. tomentosa extract, which also showed the highest activity against the cancer cells. The ethanol extract from E. phaseoloides exhibited tyrosinase inhibition activity (IC50 = 543.83 ± 51.06 μg/mL). The results herein suggested that the ethanol extracts from some medicinal plants from East Kalimantan have potential as antioxidant, antibacterial, anticancer, and anti-tyrosinase agents. Penerbit Universiti Kebangsaan Malaysia 2021-08 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17578/1/5.pdf Franxisca Mariani, and Rachaneekorn Tammachote, and Kusuma, Irawan Wijaya and Warinthorn Chavasiri, and Hunsa Punnapayak, and Sehanat Prasongsuk, (2021) Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia. Sains Malaysiana, 50 (8). pp. 2193-2205. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil8_2021/KandunganJilid50Bil8_2021.html |
| spellingShingle | Franxisca Mariani, Rachaneekorn Tammachote, Kusuma, Irawan Wijaya Warinthorn Chavasiri, Hunsa Punnapayak, Sehanat Prasongsuk, Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia |
| title | Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia |
| title_full | Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia |
| title_fullStr | Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia |
| title_full_unstemmed | Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia |
| title_short | Phenolic content and biological activities of ethanol extracts from medicinal plants in East Kalimantan, Indonesia |
| title_sort | phenolic content and biological activities of ethanol extracts from medicinal plants in east kalimantan, indonesia |
| url | http://journalarticle.ukm.my/17578/ http://journalarticle.ukm.my/17578/ http://journalarticle.ukm.my/17578/1/5.pdf |