Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial
This single-blinded, non-inferiority trial was conducted over an 8-month period to examine the efficacy of intravenous granisetron at two differing doses in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) among paediatric patients receiving moderate to highly emetogenic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17535/ http://journalarticle.ukm.my/17535/1/17.pdf |
| _version_ | 1848814337453457408 |
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| author | Chong, Doris Sie Lau Soh, Cheng Khai Loh, C-Khai Syed Zulkifli Syed Zakaria, Hamidah Alias, |
| author_facet | Chong, Doris Sie Lau Soh, Cheng Khai Loh, C-Khai Syed Zulkifli Syed Zakaria, Hamidah Alias, |
| author_sort | Chong, Doris Sie Lau |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | This single-blinded, non-inferiority trial was conducted over an 8-month period to examine the efficacy of intravenous granisetron at two differing doses in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) among paediatric patients receiving moderate to highly emetogenic chemotherapy. Seventeen patients (9 males and 8 females) were recruited and randomly assigned to receive alternating granisetron dosages of 0.01 mg/kg and 0.04 mg/kg during each chemotherapy cycle. The severity of CINV during and three days post-completion of chemotherapy, as well as common side effects of granisetron were recorded. A total of 78 cycles of chemotherapy (38 cycles of 0.01 mg/kg and 40 cycles of 0.04 mg/kg) were evaluated. The median age of the study population was 5.2 years (interquartile range 25th, 3.8; 75th, 8.7). Patients’ diagnoses comprised of haematological malignancy, bone tumour and cerebral neoplasm. From this study, we demonstrated that intravenous (IV) granisetron 0.01 mg/kg was non-inferior to 0.04 mg/kg in terms of achieving a complete response for acute CINV. However, a similar observation was not seen in the post-treatment period analysis (delayed CINV). In conclusion, IV granisetron at 0.04 mg/kg/dose provides effective protection and prophylaxis of both acute and delayed CINV. Further study with a larger sample size may be required before a definite conclusion can be made with regards to efficacy of 0.01 mg/kg dose. |
| first_indexed | 2025-11-15T00:32:29Z |
| format | Article |
| id | oai:generic.eprints.org:17535 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:32:29Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:175352021-10-26T06:17:15Z http://journalarticle.ukm.my/17535/ Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial Chong, Doris Sie Lau Soh, Cheng Khai Loh, C-Khai Syed Zulkifli Syed Zakaria, Hamidah Alias, This single-blinded, non-inferiority trial was conducted over an 8-month period to examine the efficacy of intravenous granisetron at two differing doses in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) among paediatric patients receiving moderate to highly emetogenic chemotherapy. Seventeen patients (9 males and 8 females) were recruited and randomly assigned to receive alternating granisetron dosages of 0.01 mg/kg and 0.04 mg/kg during each chemotherapy cycle. The severity of CINV during and three days post-completion of chemotherapy, as well as common side effects of granisetron were recorded. A total of 78 cycles of chemotherapy (38 cycles of 0.01 mg/kg and 40 cycles of 0.04 mg/kg) were evaluated. The median age of the study population was 5.2 years (interquartile range 25th, 3.8; 75th, 8.7). Patients’ diagnoses comprised of haematological malignancy, bone tumour and cerebral neoplasm. From this study, we demonstrated that intravenous (IV) granisetron 0.01 mg/kg was non-inferior to 0.04 mg/kg in terms of achieving a complete response for acute CINV. However, a similar observation was not seen in the post-treatment period analysis (delayed CINV). In conclusion, IV granisetron at 0.04 mg/kg/dose provides effective protection and prophylaxis of both acute and delayed CINV. Further study with a larger sample size may be required before a definite conclusion can be made with regards to efficacy of 0.01 mg/kg dose. Penerbit Universiti Kebangsaan Malaysia 2021-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17535/1/17.pdf Chong, Doris Sie Lau and Soh, Cheng Khai and Loh, C-Khai and Syed Zulkifli Syed Zakaria, and Hamidah Alias, (2021) Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial. Sains Malaysiana, 50 (6). pp. 1707-1714. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil6_2021/KandunganJilid50Bil6_2021.html |
| spellingShingle | Chong, Doris Sie Lau Soh, Cheng Khai Loh, C-Khai Syed Zulkifli Syed Zakaria, Hamidah Alias, Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial |
| title | Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial |
| title_full | Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial |
| title_fullStr | Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial |
| title_full_unstemmed | Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial |
| title_short | Efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial |
| title_sort | efficacy of granisetron in the prevention of nausea and vomiting among paediatric oncology patients receiving moderate to highly emetogenic chemotherapy : a single-blinded, non-inferiority trial |
| url | http://journalarticle.ukm.my/17535/ http://journalarticle.ukm.my/17535/ http://journalarticle.ukm.my/17535/1/17.pdf |