Screening for premature coronary artery disease (CAD) using coronary artery calcium (CAC) score: a primary prevention pilot study
Acute Coronary Syndrome (ACS) events can be accelerated by positive family history of young coronary artery disease (CAD). Risk factors assessment sometimes fail to predict ACS occurrence. Additional investigations with coronary artery calcium (CAC) score can be used independently in screening...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17443/ http://journalarticle.ukm.my/17443/1/12_ms0465_pdf_16083.pdf |
| Summary: | Acute Coronary Syndrome (ACS) events can be accelerated by positive family history
of young coronary artery disease (CAD). Risk factors assessment sometimes fail to
predict ACS occurrence. Additional investigations with coronary artery calcium
(CAC) score can be used independently in screening for primary prevention in
some population. This was a cross-sectional study in asymptomatic population
with first degree relatives (FDR) having premature CAD compared with a matched
population with no family history of CAD from September 2017 to March 2018 at
the Cardiology Clinic of Univeristi Kebangsaan Malaysia Medical Centre. A total
of 36 subjects were recruited with equal number in each group. Female were the
majority in each group (66.7%). The FDR group were slightly younger compared
to the control group [mean (SD) age 36.9 (4.9) against 38 (3.8), respectively). Both
groups represent high risk factors including overweight and obesity, abdominal
obesity as well as dyslipidemia. Newly diagnosed dyslipidemia was significant
in the group with family history (83.3% versus 44.4%, P<0.01). Both groups were
screened either into the low or moderate risk Framingham Risk Score group. CAC
score was higher in family history group (11.1% vs 0%, P>0.05). In conclusion,
CAC may be irrelevant for screening in younger population. However, the yield of
other risk factor is still alarming. |
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