Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology
In recent years, with the global environmental deterioration and air pollution, the incidence of bronchitis has increased year by year, and the sales of anti-bronchitis drugs are growing rapidly, mainly due to the long treatment cycle and the difficulty of curing. Developing available traditiona...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17419/ http://journalarticle.ukm.my/17419/1/22.pdf |
| _version_ | 1848814310273318912 |
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| author | Wu, Tingting Zhang, Lihu Li, Dongdong Wu, Tao Jiang, Yan Zhao, Linguo |
| author_facet | Wu, Tingting Zhang, Lihu Li, Dongdong Wu, Tao Jiang, Yan Zhao, Linguo |
| author_sort | Wu, Tingting |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | In recent years, with the global environmental deterioration and air pollution, the incidence of bronchitis has increased
year by year, and the sales of anti-bronchitis drugs are growing rapidly, mainly due to the long treatment cycle and
the difficulty of curing. Developing available traditional Chinese medicines with significant curative effect against
bronchitis would be a promising strategy; for instance, Ginkgo seeds, as the fruit of natural plant ginkgo, has been used
in ancient times to cure coughs. However, the detailed mechanism of curing cough has not been shown yet. Investigate
the mechanism of Ginkgo seeds in the treatment of bronchitis by establishing a series of molecular networks including
active ingredients-targets, proteins interactions, biological functions, pathway, and biological processes of targets. In
this study, the main active ingredients of Ginkgo seeds and the potential targets related to bronchitis could be obtained
by retrieving corresponding database. The molecular docking study between active molecules and protein targets was
performed by Glide 6.6. Subsequently, a total of forty potential targets were manually selected. Based on this, the
ingredients-target network was constructed using Cytoscape software, as well as proteins interactions network combing
with the String database. Finally, the molecular biological function, metabolic pathway, and biological processes of
these forty targets were analyzed by Clue GO plug-in. The results indicated that these protein targets were closely related
to lipid transport, positive regulation of DNA replication, cAMP metabolic pathway, and other processes, which played
a vital role in the treatment of bronchitis by mediating interleukin 17, fluid shear stress and atherosclerosis, asthma,
renin secretion, p53, and other signaling pathways. Among these targets, the two protein ALB (Albumin) and DHRS2
(Dehydrogenase 2) can interact with compounds more frequently, and the top three compounds ranked by the docking
scores were amentoflavone, (+)-catechin-5-O-glucoside, and liquiritin, implying that these compounds might be used
for the treatment of bronchitis. It is obvious that the pharmacological effect of Ginkgo seeds on bronchitis displayed a
characteristic of multi-components, multi-targets, and multi-pathways. Nevertheless, the two protein targets and three
compounds derived from Ginkgo seeds could be further used for the explanation for Ginkgo seeds in curing bronchitis.
This research can provide a scientific basis for studying on the anti-bronchitis mechanism of Ginkgo seeds. |
| first_indexed | 2025-11-15T00:32:03Z |
| format | Article |
| id | oai:generic.eprints.org:17419 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:32:03Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:174192021-09-14T03:11:46Z http://journalarticle.ukm.my/17419/ Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology Wu, Tingting Zhang, Lihu Li, Dongdong Wu, Tao Jiang, Yan Zhao, Linguo In recent years, with the global environmental deterioration and air pollution, the incidence of bronchitis has increased year by year, and the sales of anti-bronchitis drugs are growing rapidly, mainly due to the long treatment cycle and the difficulty of curing. Developing available traditional Chinese medicines with significant curative effect against bronchitis would be a promising strategy; for instance, Ginkgo seeds, as the fruit of natural plant ginkgo, has been used in ancient times to cure coughs. However, the detailed mechanism of curing cough has not been shown yet. Investigate the mechanism of Ginkgo seeds in the treatment of bronchitis by establishing a series of molecular networks including active ingredients-targets, proteins interactions, biological functions, pathway, and biological processes of targets. In this study, the main active ingredients of Ginkgo seeds and the potential targets related to bronchitis could be obtained by retrieving corresponding database. The molecular docking study between active molecules and protein targets was performed by Glide 6.6. Subsequently, a total of forty potential targets were manually selected. Based on this, the ingredients-target network was constructed using Cytoscape software, as well as proteins interactions network combing with the String database. Finally, the molecular biological function, metabolic pathway, and biological processes of these forty targets were analyzed by Clue GO plug-in. The results indicated that these protein targets were closely related to lipid transport, positive regulation of DNA replication, cAMP metabolic pathway, and other processes, which played a vital role in the treatment of bronchitis by mediating interleukin 17, fluid shear stress and atherosclerosis, asthma, renin secretion, p53, and other signaling pathways. Among these targets, the two protein ALB (Albumin) and DHRS2 (Dehydrogenase 2) can interact with compounds more frequently, and the top three compounds ranked by the docking scores were amentoflavone, (+)-catechin-5-O-glucoside, and liquiritin, implying that these compounds might be used for the treatment of bronchitis. It is obvious that the pharmacological effect of Ginkgo seeds on bronchitis displayed a characteristic of multi-components, multi-targets, and multi-pathways. Nevertheless, the two protein targets and three compounds derived from Ginkgo seeds could be further used for the explanation for Ginkgo seeds in curing bronchitis. This research can provide a scientific basis for studying on the anti-bronchitis mechanism of Ginkgo seeds. Penerbit Universiti Kebangsaan Malaysia 2021-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17419/1/22.pdf Wu, Tingting and Zhang, Lihu and Li, Dongdong and Wu, Tao and Jiang, Yan and Zhao, Linguo (2021) Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology. Sains Malaysiana, 50 (5). pp. 1433-1444. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html |
| spellingShingle | Wu, Tingting Zhang, Lihu Li, Dongdong Wu, Tao Jiang, Yan Zhao, Linguo Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology |
| title | Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology |
| title_full | Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology |
| title_fullStr | Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology |
| title_full_unstemmed | Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology |
| title_short | Study on the mechanism of Ginkgo seeds in treating bronchitis by network pharmacology |
| title_sort | study on the mechanism of ginkgo seeds in treating bronchitis by network pharmacology |
| url | http://journalarticle.ukm.my/17419/ http://journalarticle.ukm.my/17419/ http://journalarticle.ukm.my/17419/1/22.pdf |