Down syndrome and cell therapy : a review
Cell therapy has been considered as an alternative treatment for many diseases, including Down syndrome (DS). However, this treatment remained debatable due to insufficient clinical data. Therefore, this study aims to identify and evaluate studies on the potential of cell therapy in improving th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17414/ http://journalarticle.ukm.my/17414/1/17.pdf |
| _version_ | 1848814308579868672 |
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| author | Norizam Salamt, Ruszymah Haji Idrus, Noor Wahidah Mohd Nasri, |
| author_facet | Norizam Salamt, Ruszymah Haji Idrus, Noor Wahidah Mohd Nasri, |
| author_sort | Norizam Salamt, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Cell therapy has been considered as an alternative treatment for many diseases, including Down syndrome (DS).
However, this treatment remained debatable due to insufficient clinical data. Therefore, this study aims to identify and
evaluate studies on the potential of cell therapy in improving the quality of life of DS patients. Relevant English articles
and snowball sampling from Science Direct and PubMed (published until August 2019) on the effects of cell therapy
on DS was retrieved. Only original articles on the effect of cell therapy in DS patients or Ts65Dn (trisomic) mice were
selected. Two independent reviewers reviewed the articles with selective inclusion criteria using a standard data
extraction form. Cell therapy showed no significant findings on the physical appearance, cognitive function, social,
and behavior skills of DS patients. Interestingly, implantation of murine neural stem cell (mNSC) or murine neural
progenitor cell (mNPC) showed better cell survival and response towards brain injury, decrease tau + granules and
increase granules density in the dentate gyrus in the trisomic mice. mNSC/mNPC in mice brain was found to be able
to migrate to the sites of the injury following chemokine signals and eventually provide neuroprotection and promote
axonal growth. To conclude, mNSC/mNPC implantation could be considered as an alternative treatment for DS or DS
with early onset of Alzheimer Disease (AD). |
| first_indexed | 2025-11-15T00:32:01Z |
| format | Article |
| id | oai:generic.eprints.org:17414 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:32:01Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:174142021-09-14T03:04:51Z http://journalarticle.ukm.my/17414/ Down syndrome and cell therapy : a review Norizam Salamt, Ruszymah Haji Idrus, Noor Wahidah Mohd Nasri, Cell therapy has been considered as an alternative treatment for many diseases, including Down syndrome (DS). However, this treatment remained debatable due to insufficient clinical data. Therefore, this study aims to identify and evaluate studies on the potential of cell therapy in improving the quality of life of DS patients. Relevant English articles and snowball sampling from Science Direct and PubMed (published until August 2019) on the effects of cell therapy on DS was retrieved. Only original articles on the effect of cell therapy in DS patients or Ts65Dn (trisomic) mice were selected. Two independent reviewers reviewed the articles with selective inclusion criteria using a standard data extraction form. Cell therapy showed no significant findings on the physical appearance, cognitive function, social, and behavior skills of DS patients. Interestingly, implantation of murine neural stem cell (mNSC) or murine neural progenitor cell (mNPC) showed better cell survival and response towards brain injury, decrease tau + granules and increase granules density in the dentate gyrus in the trisomic mice. mNSC/mNPC in mice brain was found to be able to migrate to the sites of the injury following chemokine signals and eventually provide neuroprotection and promote axonal growth. To conclude, mNSC/mNPC implantation could be considered as an alternative treatment for DS or DS with early onset of Alzheimer Disease (AD). Penerbit Universiti Kebangsaan Malaysia 2021-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17414/1/17.pdf Norizam Salamt, and Ruszymah Haji Idrus, and Noor Wahidah Mohd Nasri, (2021) Down syndrome and cell therapy : a review. Sains Malaysiana, 50 (5). pp. 1381-1392. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html |
| spellingShingle | Norizam Salamt, Ruszymah Haji Idrus, Noor Wahidah Mohd Nasri, Down syndrome and cell therapy : a review |
| title | Down syndrome and cell therapy : a review |
| title_full | Down syndrome and cell therapy : a review |
| title_fullStr | Down syndrome and cell therapy : a review |
| title_full_unstemmed | Down syndrome and cell therapy : a review |
| title_short | Down syndrome and cell therapy : a review |
| title_sort | down syndrome and cell therapy : a review |
| url | http://journalarticle.ukm.my/17414/ http://journalarticle.ukm.my/17414/ http://journalarticle.ukm.my/17414/1/17.pdf |