Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur
Prostate cancer is the third commonest type of cancer in Malaysian men with the incidence of 1,807 in 2018 compared to 1,186 cases reported in 2014. Prostate cancer is also known to cause disease, economic burden and lead to significant financial implications for the healthcare system. This stud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17413/ http://journalarticle.ukm.my/17413/1/16.pdf |
| _version_ | 1848814308282073088 |
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| author | Shamsul Azhar Shah, Norzaher Ismail, Syafiq Taib, Siti Nor Mat, Nazarudin Safian, |
| author_facet | Shamsul Azhar Shah, Norzaher Ismail, Syafiq Taib, Siti Nor Mat, Nazarudin Safian, |
| author_sort | Shamsul Azhar Shah, |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | Prostate cancer is the third commonest type of cancer in Malaysian men with the incidence of 1,807 in 2018 compared
to 1,186 cases reported in 2014. Prostate cancer is also known to cause disease, economic burden and lead to significant
financial implications for the healthcare system. This study aimed to measure the rate of survival and to determine the
prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. This
was a retrospective study design involving prostate cancer patients who had been diagnosed and had sought treatment
at Universiti Kebangsaan Malaysia Medical Centre from 2008 to 2017. Data were obtained from the patients’ medical
records based on TRUS biopsy. The study period was from July 2017 to December 2018. Survival probabilities were
estimated using Kaplan-Meier, and differences were compared using the log-rank test. The adjusted hazard ratio (HR)
for variables was estimated after fitting the Cox proportion hazard model. Patients’ death status due to prostate cancer
was the endpoint of the survival analysis. A total of 283 patients’ data were analysed. Total five-year and ten-year
survival rates of prostate cancer patients were 77.8 and 65.5%, respectively, regardless of the stage and treatment.
The predictor factors for survival age were ≥75 years (HR = 8.49, 95% C.I: 1.16-62.13), Gleason score ≥8 (HR = 2.36,
95% C.I: 1.18-4.73) and cancer metastasis complications (HR = 5.26, 95% C.I: 2.88-9.63). Survival rates and prognostic
factors of prostate cancer in the study were almost similar to those in nearby countries in the region. Preventive actions
such as prostate cancer screening, early detection of cancer and early treatment should be empowered to improve the
survival rate of prostate cancer patients in this hospital. |
| first_indexed | 2025-11-15T00:32:01Z |
| format | Article |
| id | oai:generic.eprints.org:17413 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:32:01Z |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:174132021-09-14T03:02:33Z http://journalarticle.ukm.my/17413/ Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur Shamsul Azhar Shah, Norzaher Ismail, Syafiq Taib, Siti Nor Mat, Nazarudin Safian, Prostate cancer is the third commonest type of cancer in Malaysian men with the incidence of 1,807 in 2018 compared to 1,186 cases reported in 2014. Prostate cancer is also known to cause disease, economic burden and lead to significant financial implications for the healthcare system. This study aimed to measure the rate of survival and to determine the prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. This was a retrospective study design involving prostate cancer patients who had been diagnosed and had sought treatment at Universiti Kebangsaan Malaysia Medical Centre from 2008 to 2017. Data were obtained from the patients’ medical records based on TRUS biopsy. The study period was from July 2017 to December 2018. Survival probabilities were estimated using Kaplan-Meier, and differences were compared using the log-rank test. The adjusted hazard ratio (HR) for variables was estimated after fitting the Cox proportion hazard model. Patients’ death status due to prostate cancer was the endpoint of the survival analysis. A total of 283 patients’ data were analysed. Total five-year and ten-year survival rates of prostate cancer patients were 77.8 and 65.5%, respectively, regardless of the stage and treatment. The predictor factors for survival age were ≥75 years (HR = 8.49, 95% C.I: 1.16-62.13), Gleason score ≥8 (HR = 2.36, 95% C.I: 1.18-4.73) and cancer metastasis complications (HR = 5.26, 95% C.I: 2.88-9.63). Survival rates and prognostic factors of prostate cancer in the study were almost similar to those in nearby countries in the region. Preventive actions such as prostate cancer screening, early detection of cancer and early treatment should be empowered to improve the survival rate of prostate cancer patients in this hospital. Penerbit Universiti Kebangsaan Malaysia 2021-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17413/1/16.pdf Shamsul Azhar Shah, and Norzaher Ismail, and Syafiq Taib, and Siti Nor Mat, and Nazarudin Safian, (2021) Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. Sains Malaysiana, 50 (5). pp. 1367-1379. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html |
| spellingShingle | Shamsul Azhar Shah, Norzaher Ismail, Syafiq Taib, Siti Nor Mat, Nazarudin Safian, Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur |
| title | Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur |
| title_full | Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur |
| title_fullStr | Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur |
| title_full_unstemmed | Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur |
| title_short | Survival analysis and prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur |
| title_sort | survival analysis and prognostic factors for prostate cancer patients at universiti kebangsaan malaysia medical centre, kuala lumpur |
| url | http://journalarticle.ukm.my/17413/ http://journalarticle.ukm.my/17413/ http://journalarticle.ukm.my/17413/1/16.pdf |