Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery
This study compared the analgesic effects of pre-emptive intravenous magnesium sulphate of different dosages in patients undergoing lower abdominal gynaecological surgery. Fifty-six patients with Body Mass Index (BMI) <35 kg/m2 who underwent lower abdominal gynaecological surgery were ran...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/16278/ http://journalarticle.ukm.my/16278/1/16_ms0429_pdf_29637.pdf |
| _version_ | 1848814011998535680 |
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| author | Tan, HY Cheah, SK Azrin MA, Ooi Su Min, Joanna Su Min |
| author_facet | Tan, HY Cheah, SK Azrin MA, Ooi Su Min, Joanna Su Min |
| author_sort | Tan, HY |
| building | UKM Institutional Repository |
| collection | Online Access |
| description | This study compared the analgesic effects of pre-emptive intravenous magnesium
sulphate of different dosages in patients undergoing lower abdominal gynaecological
surgery. Fifty-six patients with Body Mass Index (BMI) <35 kg/m2
who underwent
lower abdominal gynaecological surgery were randomly recruited into two
groups. Group I received one ampoule (2.47 g) of magnesium sulphate and Group
II received 50 mg/kg magnesium sulphate (based on body weight), pre-operatively.
Pain score and patient controlled analgesia (PCA) morphine requirement were
compared at 30 minutes, 12 hours and 24 hours post-operatively. The pain score
was comparable at all intervals between the two groups (30 minutes, p = 0.450;
12 hours, p = 0.402; and 24 hours, p = 1.000). Post-operative PCA morphine
requirement was not statistically significant between the two groups at 30 minutes,
12 hours, and 24 hours (2.7 vs 2.4 mg, p = 0.545; 12.5 vs 9.8 mg, p = 0.154; 7.7
vs 6.4 mg, p = 0.323). The side-effects of magnesium sulphate on blood pressure,
heart rate and sedation were not statistically significant between the two groups. In
conclusion, the analgesic effects of pre-emptively administered intravenous MgSO4
of 2.47 g (one ampule) was comparable to 50 mg/kg in patients with BMI less
than 35 kg/m2
following lower abdominal gynaecological surgery under general
anaesthesia with negligible side effects. |
| first_indexed | 2025-11-15T00:27:18Z |
| format | Article |
| id | oai:generic.eprints.org:16278 |
| institution | Universiti Kebangasaan Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T00:27:18Z |
| publishDate | 2020 |
| publisher | Pusat Perubatan Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | oai:generic.eprints.org:162782021-03-16T02:48:36Z http://journalarticle.ukm.my/16278/ Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery Tan, HY Cheah, SK Azrin MA, Ooi Su Min, Joanna Su Min This study compared the analgesic effects of pre-emptive intravenous magnesium sulphate of different dosages in patients undergoing lower abdominal gynaecological surgery. Fifty-six patients with Body Mass Index (BMI) <35 kg/m2 who underwent lower abdominal gynaecological surgery were randomly recruited into two groups. Group I received one ampoule (2.47 g) of magnesium sulphate and Group II received 50 mg/kg magnesium sulphate (based on body weight), pre-operatively. Pain score and patient controlled analgesia (PCA) morphine requirement were compared at 30 minutes, 12 hours and 24 hours post-operatively. The pain score was comparable at all intervals between the two groups (30 minutes, p = 0.450; 12 hours, p = 0.402; and 24 hours, p = 1.000). Post-operative PCA morphine requirement was not statistically significant between the two groups at 30 minutes, 12 hours, and 24 hours (2.7 vs 2.4 mg, p = 0.545; 12.5 vs 9.8 mg, p = 0.154; 7.7 vs 6.4 mg, p = 0.323). The side-effects of magnesium sulphate on blood pressure, heart rate and sedation were not statistically significant between the two groups. In conclusion, the analgesic effects of pre-emptively administered intravenous MgSO4 of 2.47 g (one ampule) was comparable to 50 mg/kg in patients with BMI less than 35 kg/m2 following lower abdominal gynaecological surgery under general anaesthesia with negligible side effects. Pusat Perubatan Universiti Kebangsaan Malaysia 2020-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16278/1/16_ms0429_pdf_29637.pdf Tan, HY and Cheah, SK and Azrin MA, and Ooi Su Min, Joanna Su Min (2020) Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery. Medicine & Health, 15 (2). pp. 164-174. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/15/2 |
| spellingShingle | Tan, HY Cheah, SK Azrin MA, Ooi Su Min, Joanna Su Min Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery |
| title | Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery |
| title_full | Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery |
| title_fullStr | Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery |
| title_full_unstemmed | Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery |
| title_short | Evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery |
| title_sort | evaluation of two different doses of pre-emptive intravenous magnesium sulphate as post operative adjunct analgesia after gynaecological surgery |
| url | http://journalarticle.ukm.my/16278/ http://journalarticle.ukm.my/16278/ http://journalarticle.ukm.my/16278/1/16_ms0429_pdf_29637.pdf |